A5070994764- Health Systems, Economic Evaluations, Quality of Life
- Ethics in Clinical Research
- Patient-Provider Communication in Healthcare
- Healthcare cost, quality, practices
- Healthcare Policy and Management
- COVID-19 and healthcare impacts
- Breast Cancer Treatment Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Meta-analysis and systematic reviews
- Dialysis and Renal Disease Management
- Biomedical Ethics and Regulation
- Health and Medical Research Impacts
- Surgical site infection prevention
- BRCA gene mutations in cancer
- Orthopedic Surgery and Rehabilitation
- Delphi Technique in Research
- Colorectal Cancer Surgical Treatments
- Surgical Sutures and Adhesives
- Prostate Cancer Treatment and Research
- Health Policy Implementation Science
- Prostate Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Cancer Genomics and Diagnostics
- Stoma care and complications
- Pediatric health and respiratory diseases
University of Bristol
2016-2025
University Hospitals Bristol NHS Foundation Trust
2021-2024
NIHR Bristol Biomedical Research Centre
2022-2024
University Hospitals Bristol and Weston NHS Foundation Trust
2024
University of Birmingham
2016-2024
University Hospitals Coventry and Warwickshire NHS Trust
2018-2023
Wolverhampton Hospital
2023
The Royal Wolverhampton NHS Trust
2023
The Patients Association
2023
Manchester University NHS Foundation Trust
2023
Pragmatic randomised controlled trials (RCTs) are considered essential to determine effective interventions for routine clinical practice, but many fail recruit participants efficiently, and some really important RCTs not undertaken because recruitment is thought be too difficult. The 'QuinteT Recruitment Intervention' (QRI) aims facilitate informed decision making by patients about RCT participation increase recruitment. This paper presents the development implementation of QRI. QRI...
Background Randomised controlled trials (RCTs) are essential for evidence-based medicine and increasingly rely on front-line clinicians to recruit eligible patients. Clinicians' difficulties with negotiating equipoise is assumed undermine recruitment, although these issues have not yet been empirically investigated in the context of observable events. We aimed investigate how conveyed during RCT recruitment appointments across six RCTs, a view (i) identifying practices that supported or...
Research has shown that recruitment to trials is a process stretches from identifying potentially eligible patients, through eligibility assessment, obtaining informed consent. The length and complexity of this pathway means many patients do not have the opportunity consider participation. This article presents development simple framework document, understand improve trial recruitment. Eight RCTs integrated QuinteT Recruitment Intervention (QRI) into main trial, feasibility or pilot study....
Background There is uncertainty about the chemotherapy sensitivity of some oestrogen receptor (ER)-positive, human epidermal growth factor 2 (HER2)-negative breast cancers. Multiparameter assays that measure expression several tumour genes simultaneously have been developed to guide use adjuvant for this cancer subtype. The provide prognostic information and claimed predict sensitivity. a dearth prospective validation studies. Optimal Personalised Treatment early usIng Analysis preliminary...
ObjectiveTo evaluate the impact of QuinteT Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied intervention. The QRI aims to understand difficulties and then implements "QRI actions" address these as proceeds.Study Design SettingA mixed-methods study, comprising (1) before-and-after comparisons rates numbers patients approached (2) qualitative case studies, including documentary analysis interviews with RCT...
Abstract Background Accurate assessment of surgical-site infection (SSI) is crucial for surveillance and research. Self-reporting patient measures are needed because current SSI tools limited assessing patients after leaving hospital. The Bluebelle Wound Healing Questionnaire (WHQ) was developed or observer completion; this study tested its acceptability, scale structure, reliability validity in with closed primary wounds abdominal surgery. Methods Patients completed the WHQ...
Randomized controlled trials (RCTs) can provide high quality evidence about the comparative effectiveness of health care interventions, but many RCTs struggle with or fail to complete recruitment. are built on principles experimental method, their planning, conduct, and interpretation depend complex social, behavioral, cultural factors that may be best understood through qualitative research. Most studies undertaken alongside involve interviews produce data used in a supportive supplicatory...
Abstract Background More than a third of the 65,000 people living with kidney failure in UK attend dialysis unit 2–5 times week to have their blood cleaned for 3–5 h. In haemodialysis (HD), toxins are removed by diffusion, which can be enhanced using high-flux dialyser. This augmented convection, as occurs haemodiafiltration (HDF), and improved outcomes been reported who able achieve high volumes convection. study compares clinical- cost-effectiveness high-volume HDF compared HD treatment...
Background The indications for septoplasty are practice-based, rather than evidence-based. In addition, internationally accepted guidelines the management of nasal obstruction associated with septal deviation lacking. Objective objective was to determine clinical effectiveness and cost-effectiveness septoplasty, or without turbinate reduction, compared medical management, in a deviated septum. Design This multicentre randomised controlled trial comparing defined management; it incorporated...
Older people with kidney failure often have a limited range of treatment options, few being well enough to receive transplant. Instead, they either start dialysis or 'conservative management' (CKM). CKM involves care that focuses on managing the symptoms and maintaining quality life in absence dialysis. The relative ability make older live longer feel better is uncertain. This study aimed describe how patients understand decide between CKM, as evidence suggests may not be fully supported...
Background NHS expenditure has stagnated since the economic crisis of 2007, resulting in financial pressures. One response is for policy-makers to regulate use existing health-care technologies and disinvest from inefficiently used health technologies. A key challenge disinvestment identify with uncertain cost-effectiveness. Objectives We aimed explore if geographical variation procedure rates a marker clinical uncertainty might be by local commissioners procedures that are potential...
Many randomised controlled trials (RCTs) struggle to recruit, despite valiant efforts. The QRI (QuinteT Recruitment Intervention) uses innovative research methods optimise recruitment by revealing previously hidden barriers related the perceptions and experiences of recruiters patients, targeting remedial actions. It was designed be integrated with RCTs anticipating difficulties at outset. A new version intervention (QRI-Two) developed for already underway enrolment shortfalls.QRIs in 12...
<h2>Abstract</h2><h3>Objectives</h3> To explore how the concept of randomization is described by clinicians and understood patients in randomized controlled trials (RCTs) it contributes to patient understanding recruitment. <h3>Study Design Setting</h3> Qualitative analysis 73 audio recordings recruitment consultations from five, multicenter, UK-based RCTs with identified or anticipated difficulties. <h3>Results</h3> One 10 appointments did not include any mention randomization. Most...
Abstract Introduction The COVID-19 pandemic impacted the operationalisation of non-COVID-19 clinical trials globally, particularly site and participant recruitment trial success/stoppage. Trials which anticipate challenges may embed methods such as QuinteT Recruitment Intervention (QRI) to help identify understand sources challenges. Such interventions can shed light on pandemic-related This paper reports our experience impact conducting with an embedded QRI, highlighting how QRI aided in...
To assess the clinical effectiveness of septoplasty.Multicentre, randomised controlled trial.17 otolaryngology clinics in UK's National Health Service.378 adults (≥18 years, 67% men) newly referred with symptoms nasal obstruction associated septal deviation and at least moderate (score >30 on Nasal Obstruction Symptom Evaluation (NOSE) scale).Participants were 1:1 to receive either septoplasty (n=188) or defined medical management (n=190, steroid saline spray for six months), stratified by...
Objectives To develop a nurse-led, urologist-supported model of care for men managed by active surveillance or monitoring (AS/AM) localised prostate cancer and provide formative evaluation its acceptability to patients, clinicians nurses. Nurse-led care, comprising an explicit nurse-led protocol with support from urologists, was developed as part the AM arm Prostate testing Treatment (ProtecT) trial. Design Interviews questionnaire surveys clinicians, nurses patients assessed acceptability....