A5062199044- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrest and Resuscitation
- COVID-19 and healthcare impacts
- Respiratory Support and Mechanisms
- Opioid Use Disorder Treatment
- Airway Management and Intubation Techniques
- Pain Management and Opioid Use
- Telemedicine and Telehealth Implementation
- Sepsis Diagnosis and Treatment
- Hip and Femur Fractures
- Employment and Welfare Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmaceutical Economics and Policy
- Healthcare Policy and Management
- Surgical Simulation and Training
- Homelessness and Social Issues
- Simulation-Based Education in Healthcare
- Pediatric Pain Management Techniques
- Chronic Disease Management Strategies
- Computational Drug Discovery Methods
- Cardiac Ischemia and Reperfusion
- Traumatic Brain Injury Research
University of Bristol
2016-2025
University Hospitals Bristol NHS Foundation Trust
2018-2024
National Institute for Health Research
2018-2024
University Hospitals Bristol and Weston NHS Foundation Trust
2020-2024
Macquarie University
2024
NIHR Applied Research Collaboration West
2020-2024
University of Kansas Medical Center
2024
Newcastle University
2023
Mount Sinai Hospital
2023
NIHR Bristol Biomedical Research Centre
2020-2022
Background To reduce contagion of COVID-19, in March 2020 UK general practices implemented predominantly remote consulting via telephone, video, or online consultation platforms. Aim investigate the rapid implementation and explore impact over initial months COVID-19 pandemic. Design setting Mixed-methods study 21 Bristol, North Somerset South Gloucestershire. Method Longitudinal observational quantitative analysis compared volume type April to July with 2019. Negative binomial models were...
<h3>Importance</h3> The optimal approach to airway management during out-of-hospital cardiac arrest is unknown. <h3>Objective</h3> To determine whether a supraglottic device (SGA) superior tracheal intubation (TI) as the initial advanced strategy in adults with nontraumatic arrest. <h3>Design, Setting, and Participants</h3> Multicenter, cluster randomized clinical trial of paramedics from 4 ambulance services England responding emergencies for approximately 21 million people. Patients aged...
Background Bevacizumab (Avastin ® , Roche), which is used in cancer therapy, the ‘parent’ molecule from ranibizumab (Lucentis Novartis) was derived for treatment of neovascular age-related macular degeneration (nAMD). There were reports literature on effectiveness bevacizumab treating nAMD, but no trials. The cost per dose about 5–10% that ranibizumab. This trial a head-to-head comparison these two drugs. Objective To compare clinical and cost-effectiveness bevacizumab, regimens, nAMD....
ObjectiveTo evaluate the impact of QuinteT Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied intervention. The QRI aims to understand difficulties and then implements "QRI actions" address these as proceeds.Study Design SettingA mixed-methods study, comprising (1) before-and-after comparisons rates numbers patients approached (2) qualitative case studies, including documentary analysis interviews with RCT...
PurposeTo report on the development and progression of macular atrophy (MA) its relationship with morphologic functional measures in study fellow eyes Inhibition vascular endothelial growth factor (VEGF) Age-related Choroidal Neovascularisation trial.DesignReading center analysis data from a randomized controlled trial.ParticipantsParticipants previously untreated neovascular age-related degeneration (nAMD) eye.MethodsColor, fluorescein angiography (FA) OCT images acquired at baseline during...
Background Early warning scores (EWS) were developed in acute hospital settings to improve recognition and response patient deterioration. In 2012, the UK Royal College of Physicians National Warning Score (NEWS) standardise EWS across NHS. Its use was also recommended outside settings; however, there is limited information about NEWS these settings. From March 2015, implemented healthcare system West England, with aim that would be calculated for all patients prior referral into care. Aim...
Background NHS England has mandated use of the National Early Warning Score (NEWS), more recently NEWS2, in acute settings, and suggested its primary care. However, there is reluctance from GPs to adopt NEWS/NEWS2. Aim To assess whether NEWS calculated at point GP referral into hospital associated with outcomes secondary Design setting An observational study using routinely collected data Method values were prospectively for 13 047 referrals care between July 2017 December 2018. examined...
Background National Early Warning Scores (NEWS2) are used to detect all-cause deterioration. While studies have looked at NEWS2, the use of virtual consultation and remote monitoring patients with COVID-19 mean there is a need know which physiological observations important. Aim To investigate relationship between outcome change in NEWS2 component physiology inpatients. Methods A multi-centre retrospective study electronically recorded, routinely collected measurements March June 2020. First...
Over the years, numerous studies have explored green synthesis of ethylene. Within this context, focus perspective shifts toward plasma technology, which has demonstrated capability to convert methane into Plasma catalysis creates distinctive physical and chemical environments, particularly at normal temperature pressure, distinguishing it from alternative methods. Nevertheless, utilization atmospheric pressure is intricate, posing scientific challenges in realms physics chemistry. In...
Objectives To identify predictors of persisting symptoms after concussion (PSaC) in children, following any medically attended traumatic brain injury (TBI). Design Retrospective cohort study. Setting Linked primary and secondary care data from UK Clinical Practice Research Datalink Hospital Episode Statistics. Participants Children aged 1–17 years with a TBI between 2013 2017. Main outcome measure A binary indicator PSaC or suspected PSaC, measured using either clinical code for medical...
Abstract Background : To reduce contagion of COVID-19, in March 2020 UK general practices implemented predominantly remote consulting via telephone, video or online consultation platforms. Aim investigate the rapid implementation and explore impact over initial months COVID-19 pandemic. Design Setting: Mixed-methods study 21 Bristol, North Somerset South Gloucestershire. Methods Q uantitative Longitudinal observational analysis comparing volume type consultations April-July with 2019....
In March 2020, the COVID-19 pandemic required a rapid reconfiguration of UK general practice to minimise face-to-face contact with patients reduce infection risk. However, some remained necessary and practices needed ensure such could continue safely.To examine how determined when was consultations were reconfigured risk.Qualitative interview study in Bristol, North Somerset, South Gloucestershire.Longitudinal semi-structured interviews clinical managerial staff undertaken at four timepoints...
Objectives Stratification approaches are vital to address clinical heterogeneity in Sjogren’s syndrome (SS). We previously described that the Newcastle Tool (NSST) identified four distinct subtypes of SS. performed proteomic and network analysis analyse underlying pathobiology highlight potential therapeutic targets for different SS subtypes. Method profiled serum proteins using O-link technology 180 subjects. used 5 proteomics panels which included a total 454 unique proteins. Network...
Health outcomes after out of hospital cardiac arrest (OHCA) are extremely poor, with only 7-9% patients in the United Kingdom (UK) surviving to discharge. Currently emergency medical services (EMS) use either tracheal intubation or newer supraglottic airway devices (SGAs) provide advanced management during OHCA. Equipoise between two techniques has led calls for a well-designed randomised controlled trial. The primary objective AIRWAYS-2 trial is assess whether clinical effectiveness i-gel,...
Background Patients with neovascular age-related macular degeneration (nAMD) usually attend regular reviews, even when the disease is quiescent. Reviews are burdensome to health services, patients and carers. Objectives To compare proportion of correct lesion classifications made by community-based optometrists ophthalmologists from vignettes patients; estimate cost-effectiveness community follow-up compared in Hospital Eye Service (HES); ascertain views patients, their representatives,...
Background When a cardiac arrest occurs, cardiopulmonary resuscitation should be started immediately. However, there is limited evidence about the best approach to airway management during arrest. Objective The objective was determine whether or not i-gel ® (Intersurgical Ltd, Wokingham, UK) supraglottic superior tracheal intubation as initial advanced strategy in adults with non-traumatic out-of-hospital Design This pragmatic, open, parallel, two-group, multicentre, cluster randomised...
To describe serum vascular endothelial growth factor (sVEGF) in patients with neovascular age-related macular degeneration (nAMD) receiving anti-VEGF agents and associations between sVEGF systemic serious adverse events (SSAEs).Exploratory analyses of a randomized controlled trial that enrolled 610 participants nAMD compared 2 antibodies, ranibizumab bevacizumab, treatment regimens, monthly vs. discontinuous, years' follow-up.Adults aged 50+ years treatment-naïve visual acuity ≥25 letters...
To describe changes in intraocular pressure (IOP) the 'alternative treatments to Inhibit VEGF Age-related choroidal Neovascularisation (IVAN)' trial (registered as ISRCTN92166560).Randomised controlled clinical with factorial design.Patients (n=610) treatment naïve neovascular age-related macular degeneration were enrolled and randomly assigned receive either ranibizumab or bevacizumab two regimens, namely monthly (continuous) needed (discontinuous) treatment.At visits, IOP was measured...
Abstract Background Evidence on the most effective and cost-effective management of ankle fractures is sparse but evolving. A recent large RCT in older patients with unstable found that close-contact-casting was functionally equivalent more than internal fixation. We describe temporal geographic variation fracture estimate potential savings if used often patients. Methods Patients admitted to hospital England between 2007/08 2016/17 an were identified using routine episode statistics. tested...