A5056683937- Organ Transplantation Techniques and Outcomes
- Retinal Diseases and Treatments
- Ocular Oncology and Treatments
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Pancreatic function and diabetes
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Renal Transplantation Outcomes and Treatments
- Photoreceptor and optogenetics research
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Corneal surgery and disorders
- Transplantation: Methods and Outcomes
- Cell Adhesion Molecules Research
- Connexins and lens biology
- Diabetes Management and Research
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Retinopathy of Prematurity Studies
- Renal and Vascular Pathologies
Nottingham University Hospitals NHS Trust
2014-2025
Queen's Medical Centre
2015-2024
University of Nottingham
2007-2024
Sandia National Laboratories
2023
Sandia National Laboratories California
2019
University of Oslo
2014-2018
Oslo University Hospital
2005-2018
University at Buffalo, State University of New York
2016
University College London
1993-2015
Moorfields Eye Hospital
1993-2015
Background: Tissue injury induces central sensitization in the spinal cord dorsal horn neurons via mechanisms involving N‐methyl‐D‐aspartate (NMDA) receptors, leading to secondary hyperalgesia. Using punctuate mechanical hyperalgesia as a measure of sensitization, we examined whether induction and maintenance after surgery could be prevented by low‐dose infusion NMDA‐receptor antagonist ketamine. Results: The area was significantly reduced ketamine group 1, 3 7 d operation ( P < 0.01–0....
The fate of islets in clinical transplantation is unclear. To elude on this positron emission tomography combined with computed (PET/CT) was performed for 60 min during islet five patients receiving six transplants. A fraction the (23%) were labeled 18F-fluorodeoxyglucose ([(18)F]FDG) and carefully mixed unlabeled just prior to intraportal transplantation. peak radioactivity concentration liver found at 19 after start infusion corresponded only 75% what expected, indicating that are lost...
Background. Kidney transplantation generally improves long-term survival in patients with end-stage renal disease. However, older than 70 years of age, only limited data are available that directly compare the potential benefit versus dialysis. Methods. All aged above who started dialysis between 1990 and 2005 were waitlisted for kidney included study. They categorized according to time periods inclusion (1990–99 vs 2000–05). Survival rates altogether 286 analyzed a Kaplan–Meier model, as...
<h3>Background</h3> Traditional treatment of amblyopia involves either wearing a patch or atropine penalisation the better eye. A new is being developed on basis virtual reality technology allowing DVD footage computer games which present common background to both eyes and foreground, containing imagery interest, only amblyopic <h3>Methods</h3> randomised control trial was performed patients with aged 4–8 years three arms. All arms had dichoptic stimulation using shutter glass technology....
first eye cataract surgery reduces the risk of falling. Most cataracts in elderly people are bilateral. Some binocular functions (e.g. stereopsis) associated with falls. We aimed to determine if second falling and measure health gain.we randomised 239 women over 70, who had been referred a hospital ophthalmology department, one unoperated cataract, expedited (approximately 4 weeks) or routine (12 months wait) surgery. Falls were ascertained by diary, follow-up every 3 for 12 months. measured...
Abstract Background Liver transplantation is considered the standard of care for patients with hepatocellular carcinoma (HCC) within Milan criteria. in unresectable colorectal cancer liver-only disease has been shown to be associated a 5-year overall survival rate 56 per cent, compared 9 cent receiving palliative chemotherapy. The aim present study was compare disease-free (DFS) and (OS) after liver HCC those metastases. Methods Data were collected from SEcondary CAncer (SECA) database an...
purpose. To investigate the relative contribution of visual and other factors to quality life among elderly women with bilateral cataract. methods. Data were analyzed from a trial first-eye cataract surgery. Visual parameters, general health, social variables, disease-specific (VF-14 Index Function), generic (Euroqol: EQ-5D, London Handicap Scale, Barthel), intermediate (anxiety, depression, activity) outcomes measured at baseline 6 months later, when approximately half group had results....
The outer blood-retinal barrier is composed of a monolayer retinal pigment epithelium, Bruch's membrane and the choriocapillaris which fenestrated. Endothelial proliferation breaching leads to neovascular form age-related macula degeneration (ARMD). aim this study was generate an in vitro model that mimics more faithfully phenotype trilayer architecture vitro. A culture generated with epithelium (ARPE-19) cell cultures on epithelial surface amniotic human umbilical vein-derived endothelial...
There are concerns regarding potential long-term risks to the living kidney donor. Cardiovascular mortality has not been evaluated. The aim of this study was assess overall and cardiovascular in previous donors compared with a general population sample. All live Norway period 1963–2007 were included. Controls matched 3:1 for age, gender year birth provided by Statistics, Norway. Cause death retrieved from master file. Vital status as 1 January 2010 all participants, cause available until...
The outer retina (OR) is highly energy demanding. Impaired metabolism combined with high demands are expected to cause insufficiencies that make the OR susceptible complex blinding diseases such as age-related macular degeneration (AMD). Here, anatomical, physiological and quantitative molecular data were used calculate ATP expenditure of main energy-consuming processes in three cell types for night two different periods during day. predicted a rod dominated (perifovea) area 1.69 x 10 13...
<h3>AIMS</h3> Overexpression of<i>c-myc</i> protein has independent prognostic significance in a variety of primary and metastatic cutaneous melanomas which suggests possible role for this gene melanomagenesis. We have therefore examined the importance oncogene uveal melanoma studied coexpression two other products,<i>Bcl-2</i> and<i> p53</i>, might contribute to its effect. <h3>METHODS</h3> The percentage cells positive nuclear <i>c-myc</i>expression was estimated by flow cytometric...
AIMS/BACKGROUND Proton beam radiotherapy can effectively treat primary uveal melanomas of any size. Some patients, however, develop adverse late effects following treatment and the purpose this study was to determine which factors give rise a poor local outcome. METHODS The hospital records from first cohort 127 patients treated by protons 1989 1992 were reviewed retrospectively. presence rubeosis selected as measure significant ocular damage. Split file analysis performed with 73 cases...
To present long-term follow-up data on enucleations and eviscerations carried out with placement of spherical porous polyethylene implants.A retrospective, interventional, noncomparative case series all patients undergoing primary evisceration or enucleation surgery from one teaching hospital ophthalmology department.In total, 106 cases were identified. Eighty (75.5%) underwent (group A) 26 (24.5%) B). Patient demographics similar in both groups. Mean implant size group A was 20.5 mm 17.2 B....