A5073030393- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Neurological Complications and Syndromes
- Potassium and Related Disorders
- SARS-CoV-2 and COVID-19 Research
- Cardiac electrophysiology and arrhythmias
- COVID-19 Clinical Research Studies
- Polyomavirus and related diseases
- COVID-19 Impact on Reproduction
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Cardiac Valve Diseases and Treatments
- Transplantation: Methods and Outcomes
- Cardiac and Coronary Surgery Techniques
- Liver Disease and Transplantation
- Cardiac Imaging and Diagnostics
- Parathyroid Disorders and Treatments
- Birth, Development, and Health
- ECG Monitoring and Analysis
- Takotsubo Cardiomyopathy and Associated Phenomena
- Acute Myocardial Infarction Research
- Advanced Causal Inference Techniques
Telemark Hospital
2015-2025
Oslo University Hospital
2015-2025
University of Oslo
2014-2025
AstraZeneca (Brazil)
2023
Lars Research Institute
2019
Trondheim Kommune
2011
National Institute of Occupational Health
2003
University of Bergen
1991
Background. Kidney transplantation generally improves long-term survival in patients with end-stage renal disease. However, older than 70 years of age, only limited data are available that directly compare the potential benefit versus dialysis. Methods. All aged above who started dialysis between 1990 and 2005 were waitlisted for kidney included study. They categorized according to time periods inclusion (1990–99 vs 2000–05). Survival rates altogether 286 analyzed a Kaplan–Meier model, as...
Background. Deciding whether an elderly patient with end-stage renal disease is a candidate for kidney transplantation can be difficult. We aimed to evaluate pre- and early posttransplant risk factors that could predict outcome in recipients. Methods. Data from all (≥70 years, n=354), senior (60–69 n=577), control (45–54 n=563) patients receiving their first transplant at our center 1990 2005 were retrieved. Patient graft survival analyzed Cox model addressing the common including Charlson...
Kidney transplant recipients (KTRs) experienced reduced SARS-CoV-2 vaccine response and were at increased risk of severe COVID-19. It is unknown if level induced anti-receptor binding domain IgG (anti-RBD IgG) correlates with protection from survival following We aimed to evaluate the effect on breakthrough infections (BTI) COVID-19 death in KTRs.We performed a nationwide study, examining competing infection, related/unrelated death, efficacy as assessed by anti-RBD 4-10 weeks after each...
An inflammatory environment following kidney transplantation is associated with increased risk of graft loss and mortality, however, evaluation systemic inflammation not implemented in structured assessment transplant recipients. Long-term results after are satisfactory, thus tools addressing these issues needed. In this study, we tested the associations predictive abilities a predefined score one year on death-censored mortality. We included 805 patients who underwent between 2013 2017 at...
Background. Organ shortage has resulted in an increased use of expanded criteria donors for transplantation, particular kidneys from older donors. There is limited data on the impact donor age more than 75 years kidney transplant outcome. Methods. A retrospective single-center analysis deceased and outcome old setting was performed. Histologic findings (global score) graft biopsies deceased-donor scores were evaluated to observe if this information could be helpful predicting Results....
A prolonged corrected QT interval (QTc) ≥500 ms is associated with high all-cause mortality in hospitalized patients. We aimed to explore any difference short- and long-term patients QTc compared <500 after adjustment for comorbidity main diagnosis.
Elderly patients are the fastest growing population requiring renal replacement therapy. With increasing scarcity of organs, old likely to remain in dialysis. We have had an active transplant program with elderly (i.e. > or = 70 years) and present results from our experiences.From 1990 throughout 2005, we performed 301 first kidney transplantations patients. Data were compared 513 senior aged 60-69 years 512 control patients, 45-54 years, transplanted during same time period. Time dialysis...
We aimed to evaluate changes in health-related quality of life (HRQoL) patients 65 years or older from time kidney transplantation (KTx) until 1 year postengraftment.A single-center prospective study was conducted. HRQoL measured pre-KTx and at 2, 6, 12 months postengraftment using self-reported Kidney Disease Quality Life short-form version 1.3. Intraindividual scores before after KTx were evaluated. Liu Comorbidity Index registered enlisting. short-form-36 additionally compared with an...
Elderly patients are the fastest-growing group in need of renal transplantation. This study puts focus on transplant recipients their 80th year or longer at time engraftment. Is there evidence to support an absolute upper age limit for transplantation?Recipients longer, transplanted between 1983 and 2015, were included. Data retrieved from Norwegian Renal Registry end October 2015. Graft patient survivals compared with aged 70 79 years transplantation.Forty-seven older than defined period....
Background. New and more potent immunosuppressive protocols have markedly reduced the occurrence of rejections following organ transplantation. Accordingly, survival elderly kidney transplant recipients has been substantially improved in new millennium. The present study was performed to identify variables associated with outcome >70 years age modern era.
To determine predictors of mortality in patients with corrected QT interval (QTc) ≥ 500 ms a community hospital. In this retrospective observational study, we searched the electrocardiogram (ECG) database at Telemark Hospital Trust, Norway, from January 2004 to December 2014. Medication, electrolyte abnormalities, and medical conditions known prolong were recorded. From records, assessed whether prolonged QTc was noted by health care providers. We identified 1531 (age = 70 ± 15 years, 59%...
ObjectiveTo explore the trends in prevalence and incidence of multiple sclerosis (MS) Telemark, Norway (latitude 58.7-60.3˚N), over past two decades, with focus on differences between rural urban areas.MethodsData from all patients a confirmed diagnosis MS Telemark since 1993 were prospectively recorded collected retrospective chart review. Prevalence estimates January 1st 1999, 2009 2019, rates at five-year intervals 1999 2018 calculated results adjusted to European Standard Population. The...
Kidney transplantation (KT) is considered the best treatment for end-stage kidney disease (ESKD). In increasing elderly ESKD population, KT should be reserved carefully selected candidates who are expected to experience favorable outcomes. We aimed prospectively evaluate pretransplant recipient factors that may predict patient survival and can eventually guide therapeutic decisions in with ESKD.Recipient were evaluated aged ≥65 y. Comorbidity was assessed at waitlisting according Liu...
Kidney transplant recipients (KTR) are at high risk for severe COVID-19 and have demonstrated poor response to vaccination, making it unclear whether successive vaccinations offer immunity protection.We conducted a serologically guided interventional study where KTR patients that failed seroconvert were revaccinated also monitored seroconversion of following the Norwegian vaccination program. We analysed IgG anti-RBD Spike responses from dose 2 (n = 432) up after 6th 37) mRNA vaccine dose....
In the elderly, kidney transplantation is associated with increased survival and improved health-related quality of life compared dialysis treatment. We aimed to study short-term health economic effects in a population elderly transplant candidates.Self-perceived health, quality-adjusted years (QALYs) costs were evaluated 1 year before after patients included single-centre prospective 289 candidates ≥65 age.Self-perceived QALYs both significantly transplantation. At year, per QALY...
Assessing the optimal therapy for older patients (aged ≥65 years) with end-stage kidney disease requires knowledge of longevity and health-related quality life (HRQoL) outcomes. Kidney transplantation prolongs survival but its long-term impact on HRQoL in recipients is not well defined. We aimed to prospectively evaluate changes from enlisting until 3 years posttransplantation examine pretransplantation predictors outcomes.Prospective cohort study.Patients 65 enlisted at Norwegian National...
The burden of diabetes mellitus type 2 (DM2) is increasing worldwide. combination DM2 and hypertension (HT) frequently encountered. Concurrent use drugs blocking the renin angiotensin system (angiotensin-converting enzyme inhibitor (ACEI), receptor blocker (ARB)) metformin have become frequent in this group patients. That can life-threatening under certain circumstances.We present 5 patients with HT who developed severe metformin-associated lactic acidosis a setting acute renal failure,...
Age and number of recipients in need kidney re-transplantation are increasing. Re-transplantation practices outcomes elderly not previously explored. We aimed to retrospectively evaluate the 65 years older receiving their second deceased donor allograft.The study was designed as a retrospective registry based study. All or who received transplant at Oslo University Hospital between 2000 2014 were included Survival compared first (TX1) (TX2) allograft. analyses performed using Kaplan-Meier...
Summary at a Glance In cohort of 261 elderly Norwegian patients with CKD stage 5 accepted for transplant, health‐related quality life decreased modestly during the first year on waiting list. This study provides some reassurance that selected transplant candidates maintain reasonable while awaiting deceased donor kidney transplantation.
Abstract Long‐term triple immunosuppressive therapy with cyclosporine ( C s A ), mycophenolate mofetil MMF ) and prednisolone may be excessively powerful for many transplant recipients. We compared withdrawal of either or in stable kidney transplants on immunosuppression. The study was a prospective, randomized, controlled 12‐months trial transplants. patients who withdrew were given 2 g/d, troughs between 75 125 ng/mL withdrawal. Planned inclusion 298 patients. prematurely aborted after 39...
The most important limiting factor in kidney transplantation is the scarcity of donor organs. Consequently, there an increased use worldwide kidneys from older deceased donors. High age a known risk for acute cellular rejection and premature graft failure, optimal immunosuppressive regimen these circumstances remains to be established.We investigated whether induction treatment with interleukin 2 (IL-2) receptor antagonist improves survival reduces episodes recipients donors aged ≥ 60 years....
Purpose: Hyperkalemia is a common metabolic complication of chronic kidney disease (CKD) and associated with several serious adverse events. We aimed to treat/prevent hyperkalemia using the new potassium-binders, allowing maintained renin-angiotensin-aldosterone system inhibitors (RAASi) treatment in proteinuric CKD and/or congestive heart failure (CHF) patients. Patients Methods: conducted retrospective cohort study long-term users potassium binders for hyperkalemia. aged 18 years older,...