A5018708728- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Rheumatoid Arthritis Research and Therapies
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Advanced Biosensing Techniques and Applications
- COVID-19 Impact on Reproduction
- Multiple Sclerosis Research Studies
- Analytical chemistry methods development
- Inflammatory Bowel Disease
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Molecular Sensors and Ion Detection
- Spondyloarthritis Studies and Treatments
- Biosensors and Analytical Detection
- Peripheral Neuropathies and Disorders
- Nanocluster Synthesis and Applications
- Liver Diseases and Immunity
University of Oslo
2021-2024
Oslo University Hospital
2021-2024
Akershus University Hospital
2024
Hyderabad Rheumatology Center
2023
Diakonhjemmet Hospital
2023
Panjab University
2018-2021
Institute of Microbial Technology
2010-2020
Council of Scientific and Industrial Research
2013-2014
Sancheti Institute For Orthopaedics & Rehabilitation
1990
Objective Immunogenicity and safety following receipt of the standard SARS–CoV‐2 vaccination regimen in patients with immune‐mediated inflammatory diseases (IMIDs) are poorly characterized, data after third vaccine dose lacking. The aim study was to evaluate serologic responses adverse events 2‐dose a IMID receiving immunosuppressive therapy. Methods Adult therapy for rheumatoid arthritis, spondyloarthritis, psoriatic Crohn's disease, or ulcerative colitis, as well healthy adult controls,...
B-cell depletion induced by anti-cluster of differentiation 20 (CD20) monoclonal antibody (mAb) therapy patients with lymphoma is expected to impair humoral responses severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination, but effects on CD8 T-cell are unknown. Here, we investigated and following two vaccinations in undergoing anti-CD20-mAb as single agent or combination chemotherapy other anti-neoplastic agents during the last 9 months prior inclusion, healthy age-matched...
Diagnostic assays currently used to monitor the efficacy of COVID-19 vaccines measure levels antibodies receptor-binding domain ancestral SARS-CoV-2 (RBDwt). However, predictive value for protection against new variants concern (VOCs) has not been firmly established. Here, we bead-based arrays and flow cytometry binding spike proteins domains (RBDs) from VOCs in 12,000 serum samples. Effects sera on RBD-ACE2 interactions were measured as a proxy neutralizing antibodies. The samples obtained...
Objectives Humoral vaccine responses to SARS-CoV-2 vaccines are impaired and short lasting in patients with immune-mediated inflammatory diseases (IMID) following two doses. To protect these vulnerable against severe COVID-19 disease, a three-dose primary vaccination strategy has been implemented many countries. The aim of this study was evaluate humoral response safety three doses IMID. Methods Patients IMID on immunosuppressive therapy healthy controls receiving two-dose vaccination,...
Background Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron been interpreted as indicating the need for a third vaccine dose protection. However, there is little information about early immune responses to infection in individuals. Methods We measured inflammatory mediators, antibodies SARS-CoV-2 spike and nucleocapsid proteins, peptide-induced release of interferon gamma whole blood 51 double-vaccinated infected with Omicron, 14...
According to Norwegian registries, 91% of individuals ≥ 16 years had received 1 dose COVID-19 vaccine by mid-July 2022, whereas less than 2% children < 12 were vaccinated. Confirmed was reported for 27% the population, but relaxation testing lead substantial underreporting. We have characterized humoral immunity SARS-CoV-2 in Norway late summer 2022 estimating seroprevalence and identifying antibody profiles based on reactivity Wuhan or Omicron-like viruses a nationwide cross-sectional...
Medicinal plants can be used as natural therapeutics to treat diseases in humans. Enteric bacteria possess efflux pumps remove bile salts from cells avoid potential membrane damage. Resistance and antibiotics is associated with the survival of Salmonella enterica subspecies serovar Typhimurium (S. typhimurium) within a host. The present study aimed investigate binding affinity major phytocompounds derived 35 medicinal North Western Himalayas RamR protein (PDB ID 6IE9) S. typhimurium....
Abstract Specific immune detection of glycated hemoglobin is still a great challenge owing to the small epitopic difference between Hemoglobin (Hb) and HbA1c. We report new electrochemical immunoassay format for point care testing A conducting self‐assembled monolayer mercaptophenyl boronic acid (MPBA) was used as capture layer binding proteins ferrocene tagged anti‐HbA1c antibody (FcAb) tracer molecule on gold screen printed electrode. Validation HbA1c assay carried out using 6 clinical...
The manuscript highlights the efficacy of silver ions to act as a unique probe for detection bacterial contamination in water samples. cell membrane adherence property was employed develop two different assays employing colorimetric and electrochemical techniques. In one schemes, ion used directly detector bacteria assay format, other scheme surface-functionalized antibodies were primary capture specific Salmonella enterica serovar Typhi. is based on silver-induced inhibition urease activity...
Kidney transplant recipients (KTR) are at high risk for severe COVID-19 and have demonstrated poor response to vaccination, making it unclear whether successive vaccinations offer immunity protection.We conducted a serologically guided interventional study where KTR patients that failed seroconvert were revaccinated also monitored seroconversion of following the Norwegian vaccination program. We analysed IgG anti-RBD Spike responses from dose 2 (n = 432) up after 6th 37) mRNA vaccine dose....
Abstract Background One year into the COVID‐19 pandemic, cumulative number of confirmed cases in Norway was still low. In January 2021, when Norwegian vaccination campaign started, national seroprevalence estimate SARS‐CoV‐2 antibodies 3.2%. We have conducted a nationwide cross‐sectional study August 2021 to investigate overall prevalence after 8 months mass and third wave infection. Methods Residual sera were collected from laboratories across 2021. IgG against spike protein, receptor...
Immune responses in people with multiple sclerosis (pwMS) receiving disease-modifying therapies (DMTs) have been of significant interest throughout the COVID-19 pandemic. Lymphocyte-targeting immunotherapies, including anti-CD20 treatments and sphingosine-1-phosphate receptor (S1PR) modulators, attenuate Ab after vaccination. Evaluation cellular vaccination, therefore, is particular importance these populations. In this study, we used flow cytometry to analyze CD4 CD8 T cell functional...
SARS-CoV-2 infection and development of the disease COVID-19 is a serious threat to our society. Effective vaccines have now entered market, but most patient populations were not included in registration clinical trials. There evidence that patients with celiac (CeD) reduced effect such as hepatitis B vaccine. Hence, we investigated humoral response (Chadox1, Comirnaty Spikevax) CeD healthy controls.CeD from registry at Oslo University Hospital invited donate serum samples before after...
Abstract Importance Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to protect disease of 2019 (COVID-19) is recommended for patients with multiple sclerosis (pwMS). However, approximately 80% all pwMS treated anti-CD20 therapy (rituximab, ocrelizumab) or fingolimod have low absent humoral immunity after vaccination two doses SARS-CoV-2 mRNA vaccines. The efficacy and safety a third vaccine dose in this group largely unknown. Objective To characterize the...
ABSTRACT Diagnostic assays currently used to monitor the efficacy of COVID-19 vaccines measure levels antibodies receptor-binding domain ancestral SARS-CoV-2 (RBDwt). However, predictive value for protection against new variants concern (VOCs) has not been firmly established. Here, we bead-based arrays and flow cytometry binding spike proteins domains (RBDs) from VOCs in 12,000 sera. Effects sera on RBD-ACE2 interactions were measured as a proxy neutralizing antibodies. The samples obtained...