A5058016891- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Food Allergy and Anaphylaxis Research
- Health, Environment, Cognitive Aging
- Asthma and respiratory diseases
- Birth, Development, and Health
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Allergic Rhinitis and Sensitization
- Immunotoxicology and immune responses
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Animal testing and alternatives
- Indoor Air Quality and Microbial Exposure
- Noise Effects and Management
- Long-Term Effects of COVID-19
- Nutrition, Genetics, and Disease
- Insect Resistance and Genetics
- Genetically Modified Organisms Research
- Climate Change and Health Impacts
- Pediatric health and respiratory diseases
- Vitamin D Research Studies
Norwegian Institute of Public Health
2015-2024
Akershus University Hospital
2024
University of Oslo
2024
Norwegian University of Life Sciences
2022
Stanford University
2014-2021
Nasjonalforeningen for Folkehelsen
2020
Institute of Public Health Zadar
2018
Cosmetics Europe
2013
BioDetection Systems (Netherlands)
2012
Maastricht University
2012
Perfluoroalkyl substances (PFAS) are suggested to have immunosuppressive effects; exposure in utero and the first years of life is special concern as fetuses small children highly vulnerable toxicant exposure. The objective this study was investigate effect pre-natal PFAS on responses pediatric vaccines immune-related health outcomes up 3 age. In prospective birth-cohort BraMat, a sub-cohort Norwegian Mother Child Cohort Study (MoBa), pregnant women from Oslo Akershus, Norway, were recruited...
The adjuvant effect of particles on allergic immune responses has been shown to increase with decreasing particle size and increasing surface area. Like ultrafine particles, carbon nanotubes (CNTs) have nano-sized dimensions a large relative area might thus responses. Therefore, we examined whether single-walled (sw) multi-walled (mw) CNTs the capacity promote in mice, first an sc injection model thereafter intranasal model. Balb/cA mice were exposed three doses swCNT, mwCNT, as well black...
Exposure to perfluoroalkyl substances (PFASs) has been inconsistently associated with asthma, allergic diseases and airways infections in early childhood. The aim of the study was, therefore, investigate effect childhood exposure PFASs on asthma allergy related outcomes before during puberty using prospective birth cohort Environment Childhood Asthma (ECA) Study. Aspects gender, period design (cross-sectional longitudinal) were also taken into consideration.Included was 378 participants PFAS...
Prenatal exposure to perfluoroalkyl substances (PFASs) has been inconsistently associated with asthma and allergic diseases increased number of infections in early childhood. We examined the association PFASs measured pregnancy childhood asthma, allergies common infectious a prospective cohort followed age 7 years. Six (out 19 measured) at least 80% measurements above limit quantification (LOQ) maternal plasma during two subcohorts Norwegian Mother Child Cohort Study (MoBa) were analyzed...
The SARS-CoV-2 Omicron variant has more than 15 mutations in the receptor binding domain of Spike protein enabling increased transmissibility and viral escape from antibodies vaccinated individuals. It is unclear how vaccine immunity protects against infection. Here we show that participants at a super-spreader event have robust recall response humoral pre-existing cellular induced by vaccines, an emergent de novo T cell to non-Spike antigens. Individuals with breakthrough infections...
Diabetes mellitus type 1 is an autoimmune disease with a genetic predisposition that triggered by environmental factors during early life. Epidemiological studies show bisphenol A (BPA), endocrine disruptor, has been detected in about 90% of all analyzed human urine samples. In this study, BPA was found to increase the severity insulitis and incidence diabetes female non obese diabetic (NOD) mice offspring after transmaternal exposure through dams' drinking water (0, 0.1, 1, 10mg/l). Both...
Most children are exposed to perfluoroalkyl substances (PFASs) through placental transfer, breastfeeding, and other environmental sources. To date, there no validated tools estimate exposure body burden during infancy childhood. In this study, we aimed (i) develop a two-generation pharmacokinetic model of prenatal postnatal perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHxS); (ii) evaluate it against measured children's levels in two studies. We...
Exposure to the endocrine disruptor (ED) bisphenol A (BPA) used in polycarbonate plastic and epoxy resins appears ubiquitous since BPA can be found over 90% of analyzed urine samples from all age groups. There is a parallel occurrence increased prevalence type 1 diabetes mellitus (T1DM) an exposure EDs last decades. T1DM caused by insulin deficiency due autoimmune destruction producing pancreatic beta cells has been suggested induced various environmental factors acting together with genetic...
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a class of synthetic compounds that have widespread use in consumer industrial applications. PFAS considered environmental pollutants various toxic properties, including effects on the immune system. Recent human studies indicate prenatal exposure to leads suppressed responses early childhood. In this study, data from Norwegian BraMat cohort was used investigate transcriptomics profiles neonatal cord blood their association with...
Particle exposure has traditionally been monitored as mass concentration of PM10 (particles with an aerodynamic diameter less than 10 μm), more recently also PM2.5. The is strongly influenced by the large particles. Therefore, particle a poor measure for characterizing amount small, possibly biologically potent We used polystyrene particles (PSP) ranging in from 0.0588 to 11.14 μm, carbon black (CB), and diesel exhaust (DEP), study adjuvant effect on immune response allergen ovalbumin (OVA)...
Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development in non-obese diabetic (NOD) mice. Here, we hypothesized oral exposure mixture endocrine disruptors BPA phthalates, relevant for human exposure, would accelerate compared alone. NOD mice were exposed (1 mg/l), phthalates (DEHP...
In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers T1D risk children. mother-infant cohort (264 dyads), high exposure pregnancy associated decreased cord serum phospholipids progression T1D-associated islet autoantibodies offspring. This PFAS-lipid association...
A crucial period for the development of immune system occurs in utero. This results a high fetal vulnerability to immunotoxic exposure, and indeed, effects have been reported, demonstrating negative on immune-related health outcomes functionality. Within NewGeneris cohort BraMat, subcohort Norwegian Mother Child Cohort Study (MoBa), immunotoxicity was demonstrated polychlorinated biphenyls dioxins, showing associations between estimated maternal intake levels reduced measles vaccination...
Abstract In mice, prenatal exposure to low doses of bisphenol A has been shown affect neurogenesis and neuronal migration in cortex, resulting disturbance both positioning the network formation between thalamus cortex offspring brain. present study we investigated whether disturbs neurodevelopment cerebellum. Two different model systems were used; from two strains mice mothers receiving drinking water before mating, during gestation lactation, chicken embryos exposed (in egg) on embryonic...
Abstract Background There are limited data on the feasibility, efficacy and safety of high‐dose oral immunotherapy ( OIT ) in children highly allergic to peanuts. Objective In peanut, we primarily aimed determine feasibility reaching maximum maintenance dose MMD 5000 mg peanut protein or, alternatively, a lower individual IMD ), by up‐dosing. Secondarily, identify adverse events AE s) factors associated with dose. Methods The TAKE ‐ AWAY trial enrolled 77 5‐15 years old, positive challenge....