A5062707996- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Cervical Cancer and HPV Research
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Influenza Virus Research Studies
- Respiratory viral infections research
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- Genital Health and Disease
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- Bacteriophages and microbial interactions
- Pediatric health and respiratory diseases
- Infant Health and Development
- Congenital Diaphragmatic Hernia Studies
- Long-Term Effects of COVID-19
- Contact Dermatitis and Allergies
- Virus-based gene therapy research
- Gut microbiota and health
Østfold Hospital Trust
2016-2025
Norwegian Institute of Public Health
2003-2025
Norwegian University of Life Sciences
2015-2023
Oslo University Hospital
2020-2023
University of Oslo
2020
Akershus University Hospital
2009-2016
Norwegian Veterinary Institute
2004-2013
Background: Growth differentiation factor 15 (GDF-15) is a strong prognostic marker in sepsis and cardiovascular disease (CVD). The value of GDF-15 coronavirus 2019 (COVID-19) unknown. Methods: Consecutive, hospitalized patients with laboratory-confirmed infection severe acute respiratory syndrome 2 (SARS-CoV-2) symptoms COVID-19 were enrolled the prospective, observational COVID Mechanisms Study. Biobank samples collected at baseline, day 3 9. primary end point was admission to intensive...
Abstract Here, we randomized 53 patients hospitalized with coronavirus disease 2019 (COVID-19) to hydroxychloroquine therapy (at a dose of 400 mg twice daily for seven days) in addition standard care or alone (ClinicalTrials.gov Identifier, NCT04316377). All severe acute respiratory syndrome 2 (SARS-CoV-2) positive 18 years age older were eligible study inclusion if they had moderately COVID-19 at admission. Treatment did not result significantly greater rate decline SARS-CoV-2 oropharyngeal...
Relatively little is known about the ecological forces shaping gut microbiota composition during infancy. Therefore, objective of present study was to identify nutrient utilization- and short-chain fatty acid (SCFA) production potential microbes in infants first year life. Stool samples were obtained from mothers at 18 weeks pregnancy birth (first stool) 3, 6, 12-months age general population-based PreventADALL cohort. We identified taxonomic SCFA 100 mother-child pairs. The substrate...
Early-life microbial colonization of the skin may modulate immune system and impact development atopic dermatitis (AD) allergic diseases later in life. To address this question, we assessed association between microbiome AD, barrier integrity first year We further explored evolution with age its possible determinants, including delivery mode.
Summary There is no diagnostic test for primary immune thrombocytopenia (ITP). Certain microRNAs have shown to potential in ITP. We validated 12 identified from two previous studies find a biomarker. The study included ITP cohorts ( n = 61) and healthy controls 28). first cohort involved 24 patients the Prolong study, with newly diagnosed/persistent (<1 year) treated corticosteroids ± IVIG but relapsed/failed respond. second comprised 37 biobank, Østfold Hospital, Norway, had different...
In light of the finding a previously unknown coronavirus as aetiology severe acute respiratory syndrome (SARS), it is probable that other coronaviruses, than those recognized to date, are circulating in animal populations. Here, results screening for presented, using universal RT-PCR, bird species graylag goose ( Anser anser ), feral pigeon Columbia livia ) and mallard Anas platyrhynchos ). Coronaviruses were found cloacal swab samples from all three species. goose, 40 163 sampled birds...
In the 3′ non-coding region of genomes infectious bronchitis virus, an avian coronavirus and picornavirus equine rhinovirus serotype 2, there is a motif with remarkable similarity, both in sequence folding, to second RNA stem-loop from end human astro-viruses. This was also found astroviruses sheep, pig turkey, suggesting that it common feature all astroviruses. The conserved nature indicates has been strong selection for its preservation. There significant homology between regions flanking...
Local treatment for cervical intraepithelial neoplasia (CIN) by Loop Electrosurgical Excision Procedure (LEEP) has been correlated with reproductive morbidity, while the cervicovaginal microbiota is also known to affect risk of preterm delivery. CIN and LEEP might change microbiota. The main aim this study was describe before after assess its associaton cone depth HPV persistence. Further, we aimed compare references normal cytology. Between 2005 2007, prospectively identified 89 women...
Factors predicting allergic sensitization in the first 6 months of life are poorly understood. We aimed to determine whether eczema, dry skin, and high transepidermal water loss (TEWL) at 3 were associated with age and, secondarily, establish these characteristics predicted from age.At age, 1,994 infants population-based PreventADALL birth cohort Norway Sweden assessed for eczema skin on cheeks and/or extensors; impaired barrier function, defined as TEWL upper quartile (>9.4 g/m2 /h),...
In the present study we investigated cross-sectional positivity for DNA and E6/E7 mRNA from high-risk human papillomavirus (HPV) types in 643 women with high-grade cervical neoplasia (135 cases of intraepithelial grade 2 [CIN2], 495 CIN3/adenocarcinoma situ [ACIS], 13 invasive carcinoma) 736 normal cytology by using Amplicor PreTect HPV-Proofer assays. addition, genotyping was performed Linear Array a positive HPV test all histologically confirmed CIN2+. cytology, 8.3% (61/736) were 3.3%...
A highly conserved RNA-motif of yet unknown function, called stem-loop-2-like motif (s2m), has been identified in the 3' end genomes viruses belonging to different RNA virus families which infect a broad range mammal and bird species, including Astroviridae, Picornaviridae, Coronaviridae Caliciviridae. Since s2m is such an extremely motif, it ideal target for screening harbouring it. In this study, we have detected characterized novel pigeons by using s2m-specific amplification. 84% 67%...
The genetic element s2m seems to represent one of very few examples mobile elements in viruses. function remains obscure and a scattered taxonomical distribution has been reported by numerous groups. We have searched GenBank order identify all viral accessions that s2m(−like) sequence motifs. Rigorous phylogenetic analyses constrained tree topology testing were also performed investigate the apparently nature s2m. stem-loop structure can be found four families + ssRNA viruses; Astroviridae,...
Comparative data on different self-collection methods is limited.To assess the impact of hrHPV testing two devices for detection cervical carcinoma and high-grade lesions.Three hundred ten patients collected cervicovaginal specimens using a brush (Evalyn®Brush) swab (FLOQSwabs™), filled questionnaire at home. Then, physician clinic took specimen into PreservCyt® buffer cytology. All were tested Anyplex™ II HPV28, Cobas® 4800 HPV Test Xpert®HPV.Performance comparison included 45 carcinomas...
A woman's food intake during pregnancy has important implications not only for herself but also the future health and well-being of her child. Suboptimal dietary quality been consistently reported in many high-income countries, reflecting poor adherence to guidelines.This study aimed explore nutrients a cohort pregnant women Norway their Nordic Nutrition Recommendations (NNR) Norwegian food-based guidelines (NFG).We investigated 1,674 from mother-child birth cohort, PreventADALL, recruited...
Coronavirus disease 2019 (COVID-19) may cause myocardial injury and myocarditis, reports of persistent cardiac pathology after COVID-19 have raised concerns long-term consequences. We aimed to assess the presence abnormal cardiovascular resonance imaging (CMR) findings in patients recovered from moderate-to-severe COVID-19, its association with markers severity acute phase.Fifty-eight (49%) survivors prospective COVID MECH study, underwent CMR median 175 [IQR 105-217] days hospitalization....
We have sequenced the genomic 3′-end, including structural gene, of human astrovirus (HAstV) serotype 7 and morphologically related viruses infecting pig (PAstV), sheep (OAstV) turkey (TAstV-1). These sequences were compared with corresponding available in nucleic acid databases, seven other HAstV serotypes, two avian astroviruses (TAstV-2 nephritis virus) from cat (FAstV). A 35 nt stem–loop motif near 3′-end genome, previously described as being highly conserved, was present all except...