A5064756368- Dermatology and Skin Diseases
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Metabolomics and Mass Spectrometry Studies
- Congenital Diaphragmatic Hernia Studies
- Advanced MRI Techniques and Applications
- Pregnancy and preeclampsia studies
- Cancer Risks and Factors
- Gut microbiota and health
- Radiomics and Machine Learning in Medical Imaging
- Cervical Cancer and HPV Research
- Neonatal skin health care
- Cancer, Lipids, and Metabolism
- Pediatric health and respiratory diseases
- Contact Dermatitis and Allergies
- MRI in cancer diagnosis
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Infant Health and Development
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Pregnancy and Medication Impact
- Urological Disorders and Treatments
University of Oslo
2018-2024
Oslo University Hospital
2017-2024
Norwegian University of Science and Technology
2011-2017
St Olav's University Hospital
2012-2013
Relatively little is known about the ecological forces shaping gut microbiota composition during infancy. Therefore, objective of present study was to identify nutrient utilization- and short-chain fatty acid (SCFA) production potential microbes in infants first year life. Stool samples were obtained from mothers at 18 weeks pregnancy birth (first stool) 3, 6, 12-months age general population-based PreventADALL cohort. We identified taxonomic SCFA 100 mother-child pairs. The substrate...
Early-life microbial colonization of the skin may modulate immune system and impact development atopic dermatitis (AD) allergic diseases later in life. To address this question, we assessed association between microbiome AD, barrier integrity first year We further explored evolution with age its possible determinants, including delivery mode.
Factors predicting allergic sensitization in the first 6 months of life are poorly understood. We aimed to determine whether eczema, dry skin, and high transepidermal water loss (TEWL) at 3 were associated with age and, secondarily, establish these characteristics predicted from age.At age, 1,994 infants population-based PreventADALL birth cohort Norway Sweden assessed for eczema skin on cheeks and/or extensors; impaired barrier function, defined as TEWL upper quartile (>9.4 g/m2 /h),...
Primary malignancies in adult brains are globally fatal. Computer vision, especially recent developments artificial intelligence (AI), have created opportunities to automatically characterize and diagnose tumor lesions the brain. AI approaches provided scores of unprecedented accuracy different image analysis tasks, including differentiating tumor-containing from healthy brains. models, however, perform as a black box, concealing rational interpretations that an essential step towards...
Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development novel treatment strategies. However, generation high-quality data requires that sample handling from surgical resection until analysis is performed using systematically validated procedures. In this study, we investigated the effect postsurgical freezing delay time on global metabolic...
A woman's food intake during pregnancy has important implications not only for herself but also the future health and well-being of her child. Suboptimal dietary quality been consistently reported in many high-income countries, reflecting poor adherence to guidelines.This study aimed explore nutrients a cohort pregnant women Norway their Nordic Nutrition Recommendations (NNR) Norwegian food-based guidelines (NFG).We investigated 1,674 from mother-child birth cohort, PreventADALL, recruited...
Loss-of-function mutations in the skin barrier gene filaggrin (FLG) increase risk of atopic dermatitis (AD), but their role function, dry and eczema infancy is unclear.To determine FLG impaired skin, AD at 3 months age throughout infancy.FLG were analysed 1836 infants Scandinavian population-based PreventADALL study. Transepidermal water loss (TEWL), assessed 3, 6 12 age.FLG observed 166 (9%) infants. At months, carrying was not associated with function (TEWL > 11·3 g m-2 h-1 ) or [odds...
High-Density Lipoprotein (HDL)-cholesterol, has been associated with breast cancer development, but the association is under debate, and whether lipoprotein subfractions tumor characteristics remains unclear. Among 56 women newly diagnosed invasive stage I/II, aged 35–75 years, pre-surgery overnight fasting serum concentrations of lipids were assessed, body mass index (BMI) was measured. All tumors immunohistochemically examined in surgical specimen. Serum metabolomics their contents...
Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed basal-like breast cancer (BLBC), which aggressive usually triple-negative, making it unresponsive to current targeted therapies. Here, we evaluated the anti-angiogenic effects of a specific cPLA2α inhibitor, AVX235, patient-derived triple-negative BLBC model. Mice bearing orthotopic xenografts received i.p. injections AVX235 or DMSO vehicle daily for 1 week then every...
Mutations in the isocitrate dehydrogenase (IDH) genes are frequently found gliomas and a fraction of acute myeloid leukemia patients. This results production an oncometabolite, 2-hydroxyglutarate (2-HG). Glioma patients harboring IDH mutations have longer survival than their wild-type counterparts. 2-HG has been detected noninvasively with using magnetic resonance spectroscopy (MRS), suggesting its potential clinical relevance for identifying glioma subtypes better prognosis. In this paper,...
Metastasis to the brain is a feared complication of systemic cancer, associated with significant morbidity and poor prognosis. A better understanding tumor metabolism might help us meet challenges in controlling metastases. The study aims characterize metabolic profile metastases different origin using high resolution magic angle spinning (HR-MAS) magnetic resonance spectroscopy (MRS) correlate profiles clinical pathological information. Biopsy samples human (n = 49) were investigated....
In the general population randomized controlled trial PreventADALL, frequent emollient bath additives from 2 weeks of age did not prevent atopic dermatitis, while effect on skin barrier function throughout infancy is established.
Mitochondrial impairment is a key feature underlying neonatal hypoxic-ischemic (HI) brain injury and melatonin potentially neuroprotective through its effects on mitochondria. In this study, we have used (1) H (13) C NMR spectroscopy after injection of [1-(13) C]glucose [1,2-(13) C]acetate to examine neuronal astrocytic metabolism in the early reperfusion phase unilateral HI 7-day-old rat pups, exploring mitochondrial function potential protective metabolism. One hour hypoxia-ischemia, was...
Abstract Introduction Human papillomavirus (HPV) infection is common in women of reproductive age. Infection and inflammation are leading causes for preterm delivery (PTD), but the role HPV PTD prelabor rupture membranes (PROM) unclear. We aimed to explore whether during pregnancy general, high‐risk‐HPV (HR‐HPV) specifically, increased risk PTD, (PPROM), PROM at term, and/or chorioamnionitis. Material Methods In pregnant women, who were participating a prospective multicenter cohort study...
Background Cardiovascular disease (CVD) is a leading cause of death worldwide, and the number people at risk continuously growing. New methods for early prediction are therefore needed to actuate prevention strategies before individuals diagnosed with CVD. Several studies report that aerobic fitness level, measured as maximal oxygen uptake (VO2max), single best predictor future CVD mortality in healthy people. Based on this, we wanted study differences between large difference VO2max-level...
The prognosis and treatment of astrocytomas, which are primary brain tumors, vary depending on the grade tumor, necessitating a precise preoperative classification. Magnetic resonance spectroscopy (MRS) provides information about metabolites in tissues is an emerging noninvasive tool to improve diagnostic accuracy patients with intracranial neoplasia.To investigate whether ex vivo MRS could differentiate World Health Organization II (A-II) IV astrocytomas (glioblastomas; GBM) correlate MR...
Docetaxel is one of the most frequently used drugs to treat breast cancer. However, resistance or incomplete response docetaxel a major challenge. The aim this study was utilize MR metabolomics identify potential biomarkers in mouse model for BRCA1-mutated High resolution magic angle spinning (HRMAS) 1H spectroscopy performed on tissue samples obtained from docetaxel-sensitive -resistant mammary tumors mice. Measurements were before treatment and at 1-2, 3-5 6-7 days after 25 mg/kg dose...
Diagnosing atopic dermatitis (AD) in infants is challenging.To determine the incidence and persistence of eczema AD using UK Working Party (UKWP) Hanifin Rajka (H&R) criteria.A cohort 1834 was examined clinically at 3, 6 12 months age. diagnosed by UKWP (3, months) H&R (12 criteria. Logistic regression models were used to assess relationship between eczema.Eczema observed 628 (34·2%) (n = 240, n 359 329 months, respectively), with 212 (33·7%) any 64/78 (82%) all three visits. The odds lower...