A5100341148- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Organic Electronics and Photovoltaics
- Radiomics and Machine Learning in Medical Imaging
- Thin-Film Transistor Technologies
- Organic Light-Emitting Diodes Research
- Neuroscience and Neuropharmacology Research
- Conducting polymers and applications
- Asthma and respiratory diseases
- Alzheimer's disease research and treatments
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Mathematical Biology Tumor Growth
- Angiogenesis and VEGF in Cancer
- Atomic and Subatomic Physics Research
- Ultrasound and Hyperthermia Applications
- Computational Fluid Dynamics and Aerodynamics
- Memory and Neural Mechanisms
- Bioinformatics and Genomic Networks
- Restraint-Related Deaths
- Neuroinflammation and Neurodegeneration Mechanisms
- Semiconductor materials and devices
- Nanoparticle-Based Drug Delivery
King's College London
2019-2024
SK Group (South Korea)
2012-2024
Boston University
2024
University of Zurich
2024
University of Waterloo
2023
Wellcome Centre for Human Neuroimaging
2019-2022
Nagoya University
2017-2022
ORCID
2022
University of Calgary
2021-2022
Boston Medical Center
2022
The cytochrome P450 steroid hydroxylases are coordinately regulated by steroidogenic factor 1 (SF-1), a protein expressed selectively in cells. Based on its expression tissues and DNA-binding specificity, we isolated putative SF-1 cDNA from an adrenocortical library. As evidence that this encodes SF-1, now show it is cells, antiserum against product specifically abolishes the SF-1-related gel-shift complex, coexpression increases promoter activity of 21-hydroxylase 5'-flanking region...
Familial Danish dementia (FDD), also known as heredopathia ophthalmo-oto-encephalica, is an autosomal dominant disorder characterized by cataracts, deafness, progressive ataxia, and dementia. Neuropathological findings include severe widespread cerebral amyloid angiopathy, hippocampal plaques, neurofibrillary tangles, similar to Alzheimer's disease. N-terminal sequence analysis of isolated leptomeningeal fibrils revealed homology ABri, the peptide originated a point mutation at stop codon...
Abstract Infectious or noninfectious maternal immune activation (MIA) is an environmental risk factor for psychiatric and neurological disorders with neurodevelopmental etiologies. Whilst there increasing evidence significant health consequences, the effects of MIA on offspring appear to be variable. Here, we aimed identify characterize subgroups isogenic mouse exposed identical MIA, which was induced in C57BL6/N mice by administration viral mimetic, poly(I:C), gestation day 12. Cluster...
The effect of obesity on upper airway soft tissue structure and size was examined in the New Zealand Obese (NZO) mouse a control lean mouse, White (NZW).
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition that primarily affects the motor system and shares many features with frontotemporal dementia (FTD). Evidence suggests ALS 'dying-back' disease, peripheral denervation axonal degeneration occurring before loss of neuron cell bodies. Distal to nerve injury, similar pattern can be seen, which mediated by an active axon destruction mechanism called Wallerian degeneration. Sterile alpha TIR motif-containing 1 (Sarm1) key...
Abstract Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD). Importantly, clinically relevant connection exists between inflammation and metabolic stress that can result in aberrant cytokine signaling autoimmunity. In this study we examined the potential maternal autoantibodies (aAbs) to disrupt induce neuroanatomical changes brains of exposed offspring. To accomplish this, developed model aAb exposure rats based on clinical phenomenon...
It is widely assumed that our actions shape brains and the resulting connections determine who we are. To test this idea in a reductionist setting, which genes environment are controlled, investigated differences neuroanatomy structural covariance by ex vivo magnetic resonance imaging mice whose behavioral activity was continuously tracked for 3 months large, enriched environment. We confirmed environmental enrichment increases mouse hippocampal volumes. Stratifying group according to...
Knowledge of the three-dimensional (3D) architecture blood vessels in brain is crucial because progression various neuropathologies ranging from Alzheimer's disease to tumors involves anomalous vessels. The challenges obtaining such data patients, conjunction with development mouse models neuropathology, have made murine indispensable for investigating induced neurovascular changes. Here we describe a novel method "whole brain" 3D mapping neurovasculature using magnetic resonance microscopy...
Previous studies suggest that genetic deletion of the complement C3a anaphylatoxin chemotactic receptor ( C3ar1 ), a key component innate immune response, influences behaviours associated with psychiatric symptomatology in mice but when and where is needed brain not known. These questions are significant because, as G-protein-coupled (GPCR), human C3AR1 serves potential therapeutic target for disorders dysregulation, such schizophrenia. To provide brain-wide assessment developmental...
While pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the hypothalamic ventromedial nuclei (VMN) has been shown to regulate feeding, a challenge unmasking role for this peptide obesity is that excess feeding can involve numerous mechanisms including homeostatic (hunger) and hedonic-related (palatability) drives. In these studies, we first isolated distinct drives by developing novel model of binge behavior which homeostatic-driven was temporally separated from driven...
Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed basal-like breast cancer (BLBC), which aggressive usually triple-negative, making it unresponsive to current targeted therapies. Here, we evaluated the anti-angiogenic effects of a specific cPLA2α inhibitor, AVX235, patient-derived triple-negative BLBC model. Mice bearing orthotopic xenografts received i.p. injections AVX235 or DMSO vehicle daily for 1 week then every...
It is becoming increasingly apparent that neuroinflammation plays a critical role in an array of neurological and psychiatric disorders. Recent studies have demonstrated the potential diffusion MRI (dMRI) to characterize changes microglial density morphology associated with neuroinflammation, but these were conducted mostly ex vivo and/or extreme, non-physiological animal models. Here, we build upon by investigating utility well-established dMRI methods detect more clinically relevant model...