Jolyon A. Jones
A5018612313- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- Receptor Mechanisms and Signaling
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Child Abuse and Trauma
- Birth, Development, and Health
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Tryptophan and brain disorders
University of Cambridge
2019-2024
Bridge University
2022
Early-life stress (ELS) or adversity, particularly in the form of childhood neglect and abuse, is associated with poor mental physical health outcomes adulthood. However, whether these relationships are mediated by consequences ELS itself other exposures that frequently co-occur unclear. To address this question, we carried out a longitudinal study rats to isolate effects on regional brain volumes behavioral phenotypes relevant anxiety depression. We used repeated maternal separation (RMS)...
Only some individuals who use drugs recreationally eventually develop a substance disorder, characterized in part by the rigid engagement drug foraging behavior (drug seeking), which is often maintained face of adverse consequences (i.e., compulsive). The neurobehavioral determinants this individual vulnerability have not been fully elucidated.
Major depressive disorder (MDD) is a stress-related condition hypothesized to involve aberrant reinforcement learning (RL) with positive and negative stimuli. The present study investigated whether repeated early maternal separation (REMS) stress, procedure widely recognized cause depression-like behaviour, affects how subjects learn from feedback. REMS was implemented by separating male female rats their dam for 6 h each day post-natal 5-19. Control rat offspring were left undisturbed...
Abstract Task-free functional connectivity in animal models provides an experimental framework to examine phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, acquisitions are performed varying protocols analyses that hamper result integration. We introduce StandardRat , a consensus rat MRI acquisition protocol tested across 20 centers. develop this optimized processing parameters, we initially aggregated 65 imaging datasets acquired rats...
Abstract Only some individuals using drugs recreationally eventually become addicted, and persist in drug seeking taking despite adverse consequences. The neurobehavioral determinants of this individual vulnerability have not been fully elucidated. We report that naïve rats the future tendency to develop compulsive cocaine is characterised by behavioral stickiness-related functional hypoconnectivity between prefrontal cortex posterior dorsomedial striatum combination with impulsivity-related...
The rat offers a uniquely valuable animal model in neuroscience, but we currently lack an individual-level understanding of the vivo brain network. Here, leveraging longitudinal measures cortical magnetization transfer ratio (MTR) from neuroimaging between postnatal days 20 (weanling) and 290 (mid-adulthood), design implement computational pipeline that captures network structural similarity (MIND, morphometric inverse divergence) each 53 distinct areas. We first characterized normative...
Abstract Early-life stress (ELS) or adversity, particularly in the form of childhood neglect and abuse, is associated with poor mental physical health outcomes adulthood. However, whether these relationships are mediated by consequences ELS itself other exposures that frequently co-occur unclear. To address this question, we carried out a longitudinal study rats to isolate effects on regional brain volumes behavioral phenotypes relevant anxiety depression. We used repeated maternal...