A5050157362- Congenital heart defects research
- Coronary Artery Anomalies
- Functional Brain Connectivity Studies
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Spaceflight effects on biology
- Advanced Neuroimaging Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Effects of Exercise
- Genetics and Neurodevelopmental Disorders
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- Genomic variations and chromosomal abnormalities
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroscience and Neuropharmacology Research
- Cardiac Arrhythmias and Treatments
- Exercise and Physiological Responses
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Issues in Pregnancy
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Nitric Oxide and Endothelin Effects
- Health and Conflict Studies
- Spinal Cord Injury Research
Tohoku University
2015-2024
Niigata University of Health and Welfare
2024
Institute of Aging
2015-2024
Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether prevents Alzheimer's disease (AD), AD model AppNL-G-F/NL-G-F knock-in (AppNLGF) mice were studied in combination with genetic induction Keap1FA/FA mice. While AppNLGF displayed shorter latency to escape than wild-type the passive-avoidance task, impairment was improved AppNLGF::Keap1FA/FA Matrix-assisted laser desorption ionization–mass spectrometry...
Abstract Space flight produces an extreme environment with unique stressors, but little is known about how our body responds to these stresses. While there are many intractable limitations for in-flight space research, some can be overcome by utilizing gene knockout-disease model mice. Here, we report deletion of Nrf2, a master regulator stress defense pathways, affects the health mice transported stay in International Station (ISS). After 31 days ISS, all returned safely Earth....
OBJECTIVE The cognitive deficits of vascular dementia and the vasoocclusive state moyamoya disease have often been mimicked with bilateral stenosis/occlusion common carotid artery (CCA) or internal artery. However, cerebral blood flow (CBF) declines abruptly in these models after ligation CCA, which differs from “chronic” hypoperfusion. While some modified but time-consuming techniques used staged occlusion both CCAs, others microcoils for CCA stenosis, producing an adverse effect on...
Copy number variants (CNVs) are robustly associated with psychiatric disorders and changes in brain structures. However, because CNVs contain many genes, the precise gene-phenotype relationship remains unclear. Although various volumetric alterations brains of 22q11.2 CNV carriers have been identified humans mouse models, it is unknown how each gene encoded region contributes to structural alterations, mental illnesses, their dimensions. Our previous studies Tbx1, a T-box family...
Abstract Copy number variants (CNVs) have provided a reliable entry point to identify the structural correlates of atypical cognitive development. Hemizygous deletion human chromosome 22q11.2 is associated with impaired function; however, mechanisms by which CNVs contribute deficits via diverse alterations in brain remain unclear. This study aimed determine cellular basis link between structure and functions mice heterozygous Tbx1 , one 22q11.2-encoded genes. Ex vivo whole-brain...
Traumatic events can cause long-lasting and uncontrollable fear anxiety. Posttraumatic stress disorder is an intractable mental disorder, neurobiological mechanisms using animal models are expected to help development of posttraumatic treatment. In this study, we combined multiple (MS) longitudinal in vivo magnetic resonance imaging reveal the effects anxiety-like behaviors on adult male rat brains.
Abstract Task-free functional connectivity in animal models provides an experimental framework to examine phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, acquisitions are performed varying protocols analyses that hamper result integration. We introduce StandardRat , a consensus rat MRI acquisition protocol tested across 20 centers. develop this optimized processing parameters, we initially aggregated 65 imaging datasets acquired rats...
Right ventricular failure (RVF) is a leading cause of death in patients with pulmonary hypertension; however, effective treatment remains to be developed. We have developed low-intensity pulsed ultrasound therapy for cardiovascular diseases. In this study, we demonstrated that the expression endothelial nitric oxide synthase (eNOS) RVF was downregulated and eNOS its downstream pathway were ameliorated through activation 2 animal models RVF. These results indicate an important therapeutic...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
The current method for generating an animal model of spinal cord (SC) infarction is highly invasive and permits only short-term observation, typically limited to 28 days.
Objectives: To examine whether endothelial nitric oxide synthase (eNOS) dysfunction is involved in right ventricular failure (RVF), and low-intensity pulsed ultrasound (LIPUS) therapy ameliorates RVF 2 animal models.Background: a major cause of death pulmonary arterial hypertension (PAH), for which effective treatment remains to be developed. We have previously demonstrated that the LIPUS LV models through eNOS upregulation.Methods: examined expression RV patients with RVF. used artery...
Objectives: To examine whether endothelial nitric oxide synthase (eNOS) dysfunction is involved in right ventricular failure (RVF), and low-intensity pulsed ultrasound (LIPUS) therapy ameliorates RVF 2 animal models.Background: a major cause of death pulmonary arterial hypertension (PAH), for which effective treatment remains to be developed. We have previously demonstrated that the LIPUS LV models through eNOS upregulation.Methods: examined expression RV patients with RVF. used artery...
Abstract Copy number variants (CNVs) have provided a reliable entry point to identify structural correlates of atypical cognitive development. Hemizygous deletion human chromosome 22q11.2 is associated with impaired function; however, the mechanisms by which numerous genes encoded in this CNV contribute deficits via diverse alterations brain remain unclear. This study aimed determine cellular basis link between structure and functions mouse model. The heterozygosity Tbx1, gene, altered...
名古屋大学)
Copy number variants (CNVs) are robustly associated with psychiatric disorders and their dimensions changes in brain structures behavior. However, as CNVs contain many genes, the precise gene-phenotype relationship remains unclear. Although various volumetric alterations brains of 22q11.2 CNV carriers have been identified humans mouse models, it is unknown how genes region individually contribute to structural mental illnesses dimensions. Our previous studies Tbx1, a T-box family...
Copy number variants (CNVs) are robustly associated with psychiatric disorders and their dimensions changes in brain structures behavior. However, as CNVs contain many genes, the precise gene-phenotype relationship remains unclear. Although various volumetric alterations brains of 22q11.2 CNV carriers have been identified humans mouse models, it is unknown how genes region individually contribute to structural mental illnesses dimensions. Our previous studies
Alzheimer's disease (AD) is a neurodegenerative and cause of 60% to 70% cases dementia. One characteristics diseases are chronic but moderate levels oxidative, inflammatory metabolic stresses. The KEAP1-NRF2 system plays essential roles for cellular organismal defense against oxidative electrophilic stresses by regulating battery cytoprotective genes. In this study, we analyzed the effects genetically pharmacologically activated in AD model mice. As an model, utilized knock-in mice...