Rie Ryoke

ORCID: 0000-0002-8545-0822
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Research Areas
  • Congenital heart defects research
  • Coronary Artery Anomalies
  • Functional Brain Connectivity Studies
  • Cardiovascular Function and Risk Factors
  • Pulmonary Hypertension Research and Treatments
  • Spaceflight effects on biology
  • Advanced Neuroimaging Techniques and Applications
  • Genomics, phytochemicals, and oxidative stress
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cardiovascular Effects of Exercise
  • Genetics and Neurodevelopmental Disorders
  • Advanced MRI Techniques and Applications
  • Mental Health Research Topics
  • Genomic variations and chromosomal abnormalities
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Neuroscience and Neuropharmacology Research
  • Cardiac Arrhythmias and Treatments
  • Exercise and Physiological Responses
  • Cerebrovascular and Carotid Artery Diseases
  • Cardiovascular Issues in Pregnancy
  • Stress Responses and Cortisol
  • Memory and Neural Mechanisms
  • Nitric Oxide and Endothelin Effects
  • Health and Conflict Studies
  • Spinal Cord Injury Research

Tohoku University
2015-2024

Niigata University of Health and Welfare
2024

Institute of Aging
2015-2024

Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether prevents Alzheimer's disease (AD), AD model AppNL-G-F/NL-G-F knock-in (AppNLGF) mice were studied in combination with genetic induction Keap1FA/FA mice. While AppNLGF displayed shorter latency to escape than wild-type the passive-avoidance task, impairment was improved AppNLGF::Keap1FA/FA Matrix-assisted laser desorption ionization–mass spectrometry...

10.1128/mcb.00467-19 article EN Molecular and Cellular Biology 2020-01-09
Joanes Grandjean Gabriel Desrosiers-Grégoire Cynthia Anckaerts Diego Ángeles-Valdéz Fadi Ayad and 95 more David André Barrière Ines Blockx Aleksandra Bortel Margaret Broadwater Beatriz M Cardoso Marina Célestine Jorge E. Chavez-Negrete Sangcheon Choi Emma Christiaen Perrin Clavijo Luis M. Colon‐Perez Samuel Cramer Tolomeo Daniele Elaine Dempsey Yujian Diao Arno Doelemeyer David Dopfel Lenka Dvořáková Claudia Falfan‐Melgoza Francisca F. Fernandes Caitlin Fowler Antonio Fuentes-Ibañez Clément M. Garin Eveline Gelderman Carla E. M. Golden Chao Guo Marloes J. A. G. Henckens Lauren A. Hennessy Péter Hermán Nita Hofwijks Corey Horien Tudor M. Ionescu Jolyon A. Jones Johannes Kaesser Eugene Kim Henriette Lambers Alberto Lazari Sung-Ho Lee Amanda Lillywhite Yikang Liu Yanyan Y. Liu Alejandra López-Castro Xavier López-Gil Zilu Ma Eilidh MacNicol Dan Madularu Francesca Mandino Sabina Marciano Matthew J. McAuslan Patrick McCunn Alison McIntosh Xianzong Meng Lisa Meyer-Baese Stephan Missault Federico Moro Daphne M. P. Naessens Laura Nava-Gómez Hiroi Nonaka Juan José Ortiz Jaakko Paasonen Lore M. Peeters Mickaël Pereira Pablo D. Pérez Marjory Pompilus M. J. W. Prior Rustam Rakhmatullin Henning M. Reimann Jonathan Reinwald Rodrigo Triana Del Rio Alejandro Rivera-Olvera Daniel Ruiz-Pérez Gabriele Russo Tobias J. Rutten Rie Ryoke Markus Sack Piergiorgio Salvan Basavaraju G. Sanganahalli Aileen Schroeter Bhedita J. Seewoo Erwan Selingue Aline Seuwen Bowen Shi Nikoloz Sirmpilatze Joanna A. B. Smith Corrie Smith Filip Sobczak Petteri Stenroos Milou Straathof Sandra Strobelt Akira Sumiyoshi Kengo Takahashi María Evelina Torres García Raúl Tudela Monica van den Berg Kajo van der Marel

10.1038/s41593-023-01286-8 article EN Nature Neuroscience 2023-03-27

Abstract Space flight produces an extreme environment with unique stressors, but little is known about how our body responds to these stresses. While there are many intractable limitations for in-flight space research, some can be overcome by utilizing gene knockout-disease model mice. Here, we report deletion of Nrf2, a master regulator stress defense pathways, affects the health mice transported stay in International Station (ISS). After 31 days ISS, all returned safely Earth....

10.1038/s42003-020-01227-2 article EN cc-by Communications Biology 2020-09-08

OBJECTIVE The cognitive deficits of vascular dementia and the vasoocclusive state moyamoya disease have often been mimicked with bilateral stenosis/occlusion common carotid artery (CCA) or internal artery. However, cerebral blood flow (CBF) declines abruptly in these models after ligation CCA, which differs from “chronic” hypoperfusion. While some modified but time-consuming techniques used staged occlusion both CCAs, others microcoils for CCA stenosis, producing an adverse effect on...

10.3171/2018.3.jns172274 article EN Journal of neurosurgery 2018-09-07

Copy number variants (CNVs) are robustly associated with psychiatric disorders and changes in brain structures. However, because CNVs contain many genes, the precise gene-phenotype relationship remains unclear. Although various volumetric alterations brains of 22q11.2 CNV carriers have been identified humans mouse models, it is unknown how each gene encoded region contributes to structural alterations, mental illnesses, their dimensions. Our previous studies Tbx1, a T-box family...

10.1038/s41380-024-02797-x article EN cc-by-nc-nd Molecular Psychiatry 2024-10-27

Abstract Copy number variants (CNVs) have provided a reliable entry point to identify the structural correlates of atypical cognitive development. Hemizygous deletion human chromosome 22q11.2 is associated with impaired function; however, mechanisms by which CNVs contribute deficits via diverse alterations in brain remain unclear. This study aimed determine cellular basis link between structure and functions mice heterozygous Tbx1 , one 22q11.2-encoded genes. Ex vivo whole-brain...

10.1038/s41380-021-01318-4 article EN cc-by Molecular Psychiatry 2021-11-05

Traumatic events can cause long-lasting and uncontrollable fear anxiety. Posttraumatic stress disorder is an intractable mental disorder, neurobiological mechanisms using animal models are expected to help development of posttraumatic treatment. In this study, we combined multiple (MS) longitudinal in vivo magnetic resonance imaging reveal the effects anxiety-like behaviors on adult male rat brains.

10.1016/j.bpsgos.2024.100334 article EN cc-by Biological Psychiatry Global Open Science 2024-05-15
Joanes Grandjean Gabriel Desrosiers-Grégoire Cynthia Anckaerts Diego Ángeles-Valdéz Fadi Ayad and 95 more David André Barrière Ines Blockx Aleksandra Bortel Margaret Broadwater Beatriz M Cardoso Marina Célestine Jorge E. Chavez-Negrete Sangcheon Choi Emma Christiaen Perrin Clavijo Luis M. Colon‐Perez Samuel Cramer Daniele Tolomeo Elaine Dempsey Yujian Diao Arno Doelemeyer David Dopfel Lenka Dvořáková Claudia Falfan‐Melgoza Francisca F. Fernandes Caitlin Fowler Antonio Fuentes-Ibañez Clément M. Garin Eveline Gelderman Carla E. M. Golden Chao Guo Marloes J. A. G. Henckens Lauren A. Hennessy Péter Hermán Nita Hofwijks Corey Horien Tudor M. Ionescu Jolyon A. Jones Johannes Kaesser Eugene Kim Henriette Lambers Alberto Lazari Sung‐Ho Lee Amanda Lillywhite Yikang Liu Yanyan Y. Liu Alejandra López-Castro Xavier López-Gil Zilu Ma Eilidh MacNicol Dan Madularu Francesca Mandino Sabina Marciano Matthew J. McAuslan Patrick McCunn Alison McIntosh Xianzong Meng Lisa Meyer-Baese Stephan Missault Federico Moro Daphne M. P. Naessens Laura Nava-Gómez Hiroi Nonaka Juan José Ortiz Jaakko Paasonen Lore M. Peeters Mickaël Pereira Pablo D. Pérez Marjory Pompilus M. J. W. Prior Rustam Rakhmatullin Henning M. Reimann Jonathan Reinwald Rodrigo Triana de Rio Alejandro Rivera-Olvera Daniel Ruiz-Pérez Gabriele Russo Tobias J. Rutten Rie Ryoke Markus Sack Piergiorgio Salvan Basavaraju G. Sanganahalli Aileen Schroeter Bhedita J. Seewoo Erwan Selingue Aline Seuwen Bowen Shi Nikoloz Sirmpilatze Joanna A. B. Smith Corrie Smith Filip Sobczak Petteri Stenroos Milou Straathof Sandra Strobelt Akira Sumiyoshi Kengo Takahashi María Evelina Torres García Raúl Tudela Monica van den Berg Kajo van der Marel

Abstract Task-free functional connectivity in animal models provides an experimental framework to examine phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, acquisitions are performed varying protocols analyses that hamper result integration. We introduce StandardRat , a consensus rat MRI acquisition protocol tested across 20 centers. develop this optimized processing parameters, we initially aggregated 65 imaging datasets acquired rats...

10.1101/2022.04.27.489658 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2022-04-28

Right ventricular failure (RVF) is a leading cause of death in patients with pulmonary hypertension; however, effective treatment remains to be developed. We have developed low-intensity pulsed ultrasound therapy for cardiovascular diseases. In this study, we demonstrated that the expression endothelial nitric oxide synthase (eNOS) RVF was downregulated and eNOS its downstream pathway were ameliorated through activation 2 animal models RVF. These results indicate an important therapeutic...

10.1016/j.jacbts.2022.08.010 article EN cc-by JACC Basic to Translational Science 2022-10-13

10.2502/janip.74.1.18 article JA Japanese Journal of Animal Psychology 2024-01-01

The current method for generating an animal model of spinal cord (SC) infarction is highly invasive and permits only short-term observation, typically limited to 28 days.

10.1136/svn-2023-002962 article EN cc-by-nc Stroke and Vascular Neurology 2024-06-21

Objectives: To examine whether endothelial nitric oxide synthase (eNOS) dysfunction is involved in right ventricular failure (RVF), and low-intensity pulsed ultrasound (LIPUS) therapy ameliorates RVF 2 animal models.Background: a major cause of death pulmonary arterial hypertension (PAH), for which effective treatment remains to be developed. We have previously demonstrated that the LIPUS LV models through eNOS upregulation.Methods: examined expression RV patients with RVF. used artery...

10.2139/ssrn.4050029 article EN SSRN Electronic Journal 2022-01-01

Objectives: To examine whether endothelial nitric oxide synthase (eNOS) dysfunction is involved in right ventricular failure (RVF), and low-intensity pulsed ultrasound (LIPUS) therapy ameliorates RVF 2 animal models.Background: a major cause of death pulmonary arterial hypertension (PAH), for which effective treatment remains to be developed. We have previously demonstrated that the LIPUS LV models through eNOS upregulation.Methods: examined expression RV patients with RVF. used artery...

10.2139/ssrn.4140851 article EN SSRN Electronic Journal 2022-01-01

Abstract Copy number variants (CNVs) have provided a reliable entry point to identify structural correlates of atypical cognitive development. Hemizygous deletion human chromosome 22q11.2 is associated with impaired function; however, the mechanisms by which numerous genes encoded in this CNV contribute deficits via diverse alterations brain remain unclear. This study aimed determine cellular basis link between structure and functions mouse model. The heterozygosity Tbx1, gene, altered...

10.1101/2021.03.29.437581 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2021-03-30

名古屋大学)

10.4992/pacjpa.79.0_ss-041 article EN The Proceedings of the Annual Convention of the Japanese Psychological Association 2015-09-22

Copy number variants (CNVs) are robustly associated with psychiatric disorders and their dimensions changes in brain structures behavior. However, as CNVs contain many genes, the precise gene-phenotype relationship remains unclear. Although various volumetric alterations brains of 22q11.2 CNV carriers have been identified humans mouse models, it is unknown how genes region individually contribute to structural mental illnesses dimensions. Our previous studies Tbx1, a T-box family...

10.1101/2023.06.14.545013 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2023-06-14

Copy number variants (CNVs) are robustly associated with psychiatric disorders and their dimensions changes in brain structures behavior. However, as CNVs contain many genes, the precise gene-phenotype relationship remains unclear. Although various volumetric alterations brains of 22q11.2 CNV carriers have been identified humans mouse models, it is unknown how genes region individually contribute to structural mental illnesses dimensions. Our previous studies

10.21203/rs.3.rs-3070199/v1 preprint EN cc-by Research Square (Research Square) 2023-06-30

Alzheimer's disease (AD) is a neurodegenerative and cause of 60% to 70% cases dementia. One characteristics diseases are chronic but moderate levels oxidative, inflammatory metabolic stresses. The KEAP1-NRF2 system plays essential roles for cellular organismal defense against oxidative electrophilic stresses by regulating battery cytoprotective genes. In this study, we analyzed the effects genetically pharmacologically activated in AD model mice. As an model, utilized knock-in mice...

10.1016/j.jalz.2019.06.3207 article EN Alzheimer s & Dementia 2019-07-01
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