Clément M. Garin
A5047772054- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Primate Behavior and Ecology
- Metabolomics and Mass Spectrometry Studies
- Medical Imaging Techniques and Applications
- Gene expression and cancer classification
- Photoreceptor and optogenetics research
- Fractal and DNA sequence analysis
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- Mental Health Research Topics
- Morphological variations and asymmetry
- Lanthanide and Transition Metal Complexes
- Bat Biology and Ecology Studies
- Prion Diseases and Protein Misfolding
- Gastrointestinal Tumor Research and Treatment
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Evolution and Paleontology Studies
- Neuroscience and Neural Engineering
Vanderbilt University
2022-2025
Centre National de la Recherche Scientifique
2017-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2017-2024
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2017-2024
Institut des Sciences Cognitives
2024
Université Paris-Sud
2017-2023
CEA Paris-Saclay
2020-2023
Université Paris-Saclay
2017-2023
Direction de la Recherche Fondamentale
2018-2023
Wake Forest University
2021-2022
Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer the possibility to non-invasively probe whole-brain network dynamics and investigate determinants altered signatures observed in human studies. Mouse rsfMRI has been increasingly adopted by numerous laboratories worldwide. Here we describe a multi-centre comparison 17 mouse datasets via common image processing analysis pipeline. Despite prominent cross-laboratory differences equipment procedures,...
The human default mode network (DMN) is engaged at rest and in cognitive states such as self-directed thoughts. Interconnected homologous cortical areas primates constitute a considered the equivalent. Here, based on cross-species comparison of DMN between humans non-hominoid (macaques, marmosets, mouse lemurs), we report major dissimilarities connectivity profiles. Most importantly, medial prefrontal cortex (mPFC) poorly with posterior cingulate (PCC), though strong correlated activity PCC...
Whether the size of prefrontal cortex (PFC) in humans is disproportionate when compared to other species a persistent debate evolutionary neuroscience. This question has left study over/under-expansion structures relatively unexplored. We therefore sought address this gap by adapting anatomical areas from digital atlases 18 mammalian species, create common interspecies classification. Our approach used data-driven analysis based on phylogenetic generalized least squares evaluate expansion...
Brain aging contributes to cognitive decline and risk of dementia. Degeneration the basal forebrain cholinergic system parallels these changes in aging, Alzheimer's dementia, Parkinson's Lewy body thus is a common element linked executive function across lifespan disease states. Here, we tested potential one-hour daily intermittent stimulation improve cognition senescent Rhesus monkeys, its mechanisms action. Stimulation five animals improved working memory duration each animal over 8-12...
Gadolinium (Gd)-stained MRI is based on Gd contrast agent (CA) administration into the brain parenchyma. The strong signal increase induced by CA can be converted resolution enhancement to record microscopic MR images. Moreover, inhomogeneous distribution of in improves between different tissues and provides new contrasts Gd-stained detects amyloid plaques, one lesions Alzheimer's disease (AD), APPSL/PS1M146L mice or primates. Numerous transgenic with various plaque typologies have been...
Cognitive abilities of primates, including humans, continue to improve through adolescence
Small-mammal neuroimaging offers incredible opportunities to investigate structural and functional aspects of the brain. Many tools have been developed in last decade analyse small animal data, but current softwares are less mature than available that process human brain data. The Python package Sammba-MRI (SmAll-MaMmal BrAin MRI Python; http://sammba-mri.github.io) allows flexible efficient use existing methods enables fluent scriptable analysis workflows, from raw data conversion...
Recent efforts to chart human brain growth across the lifespan using large-scale MRI data have provided reference standards for development. However, similar models nonhuman primate (NHP) are lacking. The rhesus macaque, a widely used NHP in translational neuroscience due its similarities anatomy, phylogenetics, cognitive, and social behaviors humans, serves as an ideal model. This study aimed create normative charts structure macaque lifespan, enhancing our understanding of neurodevelopment...
Measures of resting-state functional connectivity allow the description neuronal networks in humans and provide a window on brain function normal pathological conditions. Characterizing animals is complementary to studies understand how evolution has modelled network architecture. The mouse lemur (Microcebus murinus) one smallest more phylogenetically distant primates as compared humans. organization its critical for scientists studying this primate well add link comparative animal studies....
Abstract Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer the possibility to non-invasively probe whole-brain network dynamics and investigate determinants altered signatures observed in human studies. Mouse rsfMRI has been increasingly adopted by numerous laboratories world-wide. Here we describe a multi-centre comparison 17 mouse datasets via common image processing analysis pipeline. Despite prominent cross-laboratory differences equipment...
Abstract Task-free functional connectivity in animal models provides an experimental framework to examine phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, acquisitions are performed varying protocols analyses that hamper result integration. We introduce StandardRat , a consensus rat MRI acquisition protocol tested across 20 centers. develop this optimized processing parameters, we initially aggregated 65 imaging datasets acquired rats...
Glutamate is the amino acid with highest cerebral concentration. It plays a central role in brain metabolism. also principal excitatory neurotransmitter and involved multiple cognitive functions. Alterations of glutamatergic system may contribute to pathophysiology many neurological disorders. For example, changes glutamate availability are reported rodents humans during Alzheimer's Huntington's diseases, epilepsy as well aging. Most studies evaluating have used invasive or spectroscopy...
We present a dataset made of 3D digital brain templates and an atlas the gray mouse lemur (Microcebus murinus), small prosimian primate growing interest for studies biology evolution. A template image was constructed from in vivo magnetic resonance imaging (MRI) data 34 animals. This then manually segmented into 40 cortical, 74 subcortical 6 cerebro-spinal fluid (CSF) regions. Additionally, contains probability maps matter, white matter CSF. The template, manual segmentation can be...
Large-scale research integration is contingent on seamless access to data in standardized formats. Standards enable researchers understand external experiment structures, pool results, and apply homogeneous preprocessing analysis workflows. Particularly, they facilitate these features without the need for numerous potentially confounding compatibility add-ons. In small animal magnetic resonance imaging, an overwhelming proportion of acquired via ParaVision software Bruker Corporation. The...
Abstract In humans, iatrogenic transmission of cerebral amyloid-β (Aβ)-amyloidosis is suspected following inoculation pituitary-derived hormones or dural grafts presumably contaminated with Aβ proteins as well after surgeries. Experimentally, intracerebral brain homogenate extracts containing misfolded can seed deposition in transgenic mouse models amyloidosis non-human primates. The governed by the host and inoculated samples. It critical to better characterize propensities different hosts...
Les réseaux cérébraux au repos, visibles en IRM fonctionnelle, sont les reflets de l’activité intrinsèque du cerveau et donnent précieuses informations sur la fonction cérébrale saine pathologique. L’étude ces dans des modèles animaux pourrait, améliorant compréhension différences anatomiques fonctionnelles existant entre espèces mammifères, être à base d’avancées substantielles maladies neurologiques bases chez l’humain. Cependant, comparaison interspécifique est ardue car atlas cérébraux,...
Abstract Brain aging contributes to cognitive decline and risk of dementia. Degeneration the basal forebrain cholinergic system parallels these changes in aging, Alzheimer’s dementia, Parkinson’s Lewy body thus is a common element linked executive function across lifespan disease states. Here, we tested potential one-hour daily intermittent stimulation improve cognition senescent monkeys, its mechanisms action. Stimulation five animals improved working memory duration 8-12 weeks all animals,...
<title>Abstract</title> Recent efforts to chart human brain growth across the lifespan using large-scale MRI data have provided reference standards for development. However, similar models nonhuman primate (NHP) are lacking. The rhesus macaque, a widely used NHP in translational neuroscience due its similarities anatomy, phylogenetics, cognitive, and social behaviors humans, serves as an ideal model. This study aimed create normative charts structure macaque lifespan, enhancing our...
Abstract Measures of resting-state functional connectivity allow the description neuronal networks in humans and provide a window on brain function normal pathological conditions. Animal models are critical to further address experimentally their roles pathologies. Here we describe for first time network organization mouse lemur ( Microcebus murinus ), small primate attracting increased attention as model neuroscience. Resting-state MR images were recorded at 11.7 Tesla. Forty-eight regions...