A5052771182- Phytochemicals and Antioxidant Activities
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- CRISPR and Genetic Engineering
- Phytochemistry and Biological Activities
- Medical Imaging Techniques and Applications
- Genetics and Physical Performance
- Parkinson's Disease Mechanisms and Treatments
- Bone Tissue Engineering Materials
- Essential Oils and Antimicrobial Activity
- Advanced Neuroimaging Techniques and Applications
- Gastrointestinal motility and disorders
- Nutrition, Genetics, and Disease
- Natural product bioactivities and synthesis
- Advanced MRI Techniques and Applications
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Silicone and Siloxane Chemistry
- Gastroesophageal reflux and treatments
- Integrated Circuits and Semiconductor Failure Analysis
- Antioxidant Activity and Oxidative Stress
- Chemical Synthesis and Characterization
- Lysosomal Storage Disorders Research
- Mechanical stress and fatigue analysis
Cornell University
2022-2024
Weill Cornell Medicine
2022-2024
Siemens (Germany)
2019-2023
Research Network (United States)
2023
Johns Hopkins Medicine
2022
Johns Hopkins University
2022
University of Tübingen
2019-2022
Neurological Surgery
2022
University of Campania "Luigi Vanvitelli"
2013-2015
The development of biomaterials with intrinsic antioxidant properties could represent a valuable strategy for preventing the onset peri-implant diseases. In this context, quercetin, naturally occurring flavonoid, has been entrapped at different weight percentages in silica-based inorganic material by sol-gel route. establishment hydrogen bond interactions between flavonol and solid matrix was ascertained Fourier transform infrared spectroscopy. This technique also evidenced changes...
Oxidative stress has been proposed to be an important factor in the pathogenesis of Alzheimer's disease (AD), playing a central role amyloid β-protein (Aβ) generation and neuronal apoptosis. damage directly correlates with presence Aβ deposits. oxidative jointly induce death, deposits, gliosis, memory impairment AD. In order counteract AD neurodegeneration, inhibition vicious cycle oxidation is attractive therapeutic strategy, antiamyloidogenic antioxidant herbal drugs could represent...
The development of polyphenol neuroprotective nutraceuticals useful for functional foods could be a valuable strategy counteracting oxidative stress relative diseases as Alzheimer's Disease (AD). Oxidative is one the AD earliest event and seems to play central role in Aβ generation, neuroinflammation, neuronal apoptosis. In order counteract neurodegeneration, inhibition vicious cycle generation oxidation an attractive therapeutic strategy, antiamyloidogenic antioxidant plant drugs represent...
Abstract Task-free functional connectivity in animal models provides an experimental framework to examine phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, acquisitions are performed varying protocols analyses that hamper result integration. We introduce StandardRat , a consensus rat MRI acquisition protocol tested across 20 centers. develop this optimized processing parameters, we initially aggregated 65 imaging datasets acquired rats...
Receptors, transporters, and ion channels are important targets for therapy development in neurological diseases, but their mechanistic role pathogenesis is often poorly understood. Gene editing vivo imaging approaches will help to identify the molecular functional of these consequence regional dysfunction on whole-brain level. We combine CRISPR-Cas9 gene with positron emission tomography (PET) MRI (fMRI) investigate direct link between genes, molecules, brain connectome. The extensive...
The glucose tolerance test is performed to determine how quickly the cleared from blood. It used for diabetes or insulin resistance.
Mutations in the human β-globin gene are cause of β-hemoglobinopathies, one most common inherited single-gene blood disorders world. Novel therapeutic approaches based on lentiviral vectors (LVs) or CRISPR-Cas9-mediated disruption to express adult hemoglobin (HbA), reactivate completely functional fetal hemoglobin, respectively. Nonetheless, LVs present a risk insertional mutagenesis, while gene-disrupting transcription factors (BCL11A, KLF1) involved fetal-to-adult switch might generate...
This protocol outlines the steps to perform an Ovariectomy in a mouse
Behavioral assay to measure motor impairments, specifically balance and coordination, in mice.
The glucose tolerance test is performed to determine how quickly the cleared from blood. It used for diabetes or insulin resistance.
Behavioral assay to measure motor impairments, specifically balance and coordination, in mice.
Abstract Receptors, transporters and ion channels are important targets for therapy development in neurological diseases including Alzheimeŕs disease, Parkinsońs epilepsy, schizophrenia major depression. Several receptors identified by next generation sequencing may be involved disease initiation progression but their mechanistic role pathogenesis is often poorly understood. Gene editing vivo imaging approaches will help to identify the molecular functional of these consequence regional...
This test is used to check for signs of constipation
The Cylinder test is used to evaluate locomotor asymmetry in rodent models
This test is used to check for possible signs of constipation and alteration in the gut transit
The challenging beam test is used to measure motor performance, coordination, and balance