A5069429327- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Primate Behavior and Ecology
- Heme Oxygenase-1 and Carbon Monoxide
- Olfactory and Sensory Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Animal testing and alternatives
- Intracerebral and Subarachnoid Hemorrhage Research
- Genetics, Bioinformatics, and Biomedical Research
- Computational Drug Discovery Methods
- Child and Adolescent Psychosocial and Emotional Development
- Amino Acid Enzymes and Metabolism
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Autism Spectrum Disorder Research
- Diet and metabolism studies
- Children's Physical and Motor Development
- Alzheimer's disease research and treatments
Radboud University Medical Center
2018-2024
Radboud University Nijmegen
2018-2024
Henan Psychiatric Hospital
2022
Xinxiang Medical University
2022
Affiliated Hospital of Hangzhou Normal University
2021
Hangzhou Normal University
2021
East China Normal University
2021
Abstract Serotonin (5‐HT) and the habenula (Hb) contribute to motivational emotional states such as depression drug abuse. The dorsal raphe nucleus, where 5‐HT neurons originate, Hb are anatomically reciprocally interconnected. Evidence exists that influences glutamatergic transmission. Using serotonin transporter knockout (SERT −/− ) rats, which show depression‐like behavior increased cocaine intake, we investigated effect of SERT reduction on expression genes involved in glutamate...
Abstract Task-free functional connectivity in animal models provides an experimental framework to examine phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, acquisitions are performed varying protocols analyses that hamper result integration. We introduce StandardRat , a consensus rat MRI acquisition protocol tested across 20 centers. develop this optimized processing parameters, we initially aggregated 65 imaging datasets acquired rats...
Abstract Excessive use of cocaine is known to induce changes in brain white and gray matter. It unknown whether the extent these related individual differences vulnerability addiction. One factor increasing involves reduced expression serotonin transporter (5‐HTT). Human studies have shown that inherited 5‐HTT downregulation associated with structural brain. These genotype‐related may contribute risk for Here, we tested this idea by using ultrahigh‐resolution magnetic resonance imaging (MRI)...
The prefrontal cortex regulates emotions and is influenced by serotonin. Rodents lacking the serotonin transporter (5-HTT) show increased anxiety changes in excitatory inhibitory cell markers cortex. However, these observations are constrained limitations brain representation segmentation, as standard immunohistochemistry inadequate to consider volume variations regions of interest. We utilized deep learning network StarDist method combination with novel open-source methods for automated...
Abstract Serotonin transporter gene variance has long been considered an essential factor contributing to depression. However, meta-analyses yielded inconsistent findings recently, asking for further understanding of the link between and depression-related symptoms. One key feature depression is anhedonia. While data exist on effect serotonin knockout (5-HTT -/- ) in rodents consummatory anticipatory anhedonia, with mixed outcomes, decisional anhedonia not investigated thus far. Here, we...
Abstract Lower function of the serotonin transporter (5-HTT) has a strong relationship with development autism spectrum disorder (ASD) in humans. One characteristic ASD is repetitive and restrictive behavior, which may form basis for better memory savant skills some people ASD. This reflect tendency towards an exploitation strategy rather than exploration during learning. Using rat model, we developed touchscreen-based task testing 5-HTT knockout effects on stimulus category By analyzing...
Understanding the common dimension of mental disorders (such as anxiety, depression, and drug addiction) might contribute to construction biological frameworks (Research Domain Criteria, RDoC) for novel ways treatment. One at behavioral level observed across these is a generalization. Testing generalization in serotonin transporter (5-HTT) knockout (KO) rats, an animal model showing depression/anxiety-like behaviors addiction-like behaviors, could therefore provide more insights into this...
Serotonin transporter gene variance has long been considered an essential factor contributing to depression. However, meta-analyses yielded inconsistent findings recently, asking for further understanding of the link between and depression-related symptoms. One key feature depression is anhedonia. While data exist on effect serotonin knockout (5-HTT-/-) in rodents consummatory anticipatory anhedonia, with mixed outcomes, decisional anhedonia not investigated thus far. Here, we tested whether...
Objective To evaluate the differences and consistency of different diagnostic criteria for metabolic syndrome(MetS)in adolescents. Methods This cross-sectional study enrolled 920 healthy middle school students(aged 11-16 years, 53.2% males). All participants underwent anthropometric biochemical examinations, were diagnosed as MetS separately using criterion Pediatric Academy Chinese Medical Association(abbreviated criterion), 2007 International Diabetes Federation criterion(IDF Cook...