OSCC (oral squamous carcinoma) is one of most common malignant cancer.Although previous studies have found abnormal expression B7-H3 in human OSCC, the exact role and molecular mechanism remain unknown.In this study, we investigated glucose metabolic reprogramming cells vitro vivo.We first detected samples.Next, siRNAs overexpression short-hairpin RNA were transfected into SCC25 Cal27 cells, cell proliferation, migration invasion analyzed via CCK8, colony formation transwell assays.Then...

Abstract Background Dental caries is one of the most preventable oral diseases among children in developing countries. This study aims to estimate prevalence and severity dental first permanent molar analyze related risk factors sixth-grade students São Tomé Island. Methods A cross-sectional with a stratified cluster sampling method was conducted on 1855 school children, mainly aged 11 14 years old, from 10 schools 6 regions Island, April 17 June 27, 2021. examination performed by using CAST...

ABSTRACT Objectives Oral squamous cell carcinoma (OSCC) is characterized by high invasiveness and metastasis, with cancer stem cells (CSCs) playing a central role in tumor progression. This study investigates the effects of integrin‐linked kinase (ILK) silencing trichostatin A (TSA) treatment on CSCs, assessing their potential to diminish CSC properties inhibit OSCC Methods Materials CSCs were enriched isolated from primary samples Tca8113 line MOC1 using side population (SP) analysis,...

In order to solve the different pains caused by traditional cancer treatment methods such as surgical treatment, nano-drug delivery system provides new ideas for treatment. this paper, a novel anti-tumor therapy nanoparticle, P(AAm-co-AN)-AuNRs@CeO2-Ce6(PA/Ce6), is prepared, which idea liver The CeO2-coated gold nanorods were grafted onto surface of temperature-sensitive polymer P(AAm-co-AN)-CTPD. photosensitizer Ce6 loaded on nanoparticles and layer. CeO2 can effectively alleviate tumor...

The aim of the present study was to investigate expression hypoxia-inducible factor-1α (HIF-1α) in tongue squamous cell carcinoma (TSCC) and assess its possible impact on prognosis. A total 49 tumor samples 15 adjacent non-tumor from patients treated between January 2000 December 2005 at Department Oral Maxillofacial Surgery, Hospital Stomatology, Tongji University (Shanghai, China) were obtained for investigation with immunohistochemistry reverse transcription-polymerase chain reaction...

Abstract Serotonin (5‐HT) and the habenula (Hb) contribute to motivational emotional states such as depression drug abuse. The dorsal raphe nucleus, where 5‐HT neurons originate, Hb are anatomically reciprocally interconnected. Evidence exists that influences glutamatergic transmission. Using serotonin transporter knockout (SERT −/− ) rats, which show depression‐like behavior increased cocaine intake, we investigated effect of SERT reduction on expression genes involved in glutamate...

Xanthii Fructus (XF), the fruit of Xanthium sibiricum Patr., was used in treatment rhinitis and related nasal disease. Adverse effects are frequently reported these years. In paper, vitro renal cytotoxicity vivo acute chronic toxicity researches (XF) its processed product (processed (PXF)) were carried out. Water extraction XF displayed no cell membrane damage even highest concentration (100 μg/mL); however, it might affect function mitochondria. Acute toxicities observed only high middle...

Malignant tumors have long been a prominent subject of research in order to foster innovation and advancement diagnostic therapeutic modalities. However, the current clinical treatment malignant faces significant limitations. In light recent advancements, World Health Organization (WHO) officially designated as chronic disease 2006. Accordingly, maintaining tumor stable state minimizing its detrimental impact on body emerges potentially advantageous approach oncological treatment. One...

Submandibular glands have essential functions in taste, mastication, swallowing, and digestion. gland hypofunction is prevalent the elderly, impairing patients’ quality of life. Current clinical treatment strategies not decelerated or reversed pathological process submandibular hypofunction. Therefore, novel restoration should be explored. However, studies on mechanism aging-related remain very limited. The role TGF-β/Smad pathway fibrosis has been studied other organs. this study aimed to...

The present study aimed to observe the effect of biological functions integrin-linked kinase (ILK) silencing combined with hyperthermia on Tca8113 cells. Lentivirus-mediated short hairpin RNA (shRNA)-targeting ILK was transfected into oral squamous cell carcinoma (OSCC) cells and, hyperthermia, several experimental methods were used detect their behavior in vitro. On basis vitro experiments, transplanted nude mice models, and ILK-shRNA-lentivirus injected tumor hyperthermia. Tumor morphology...

Photothermal therapy (PTT) has become effective method for the treatment of malignant cancer. The development PTT system with high anti-tumour effect is still feasible research direction. Here, a new type gold nanorods (AuNRs)-doxorubicin (DOX)/mPEG 10K -peptide/P(AAm-co-AN) (APP-DOX) nano drug delivery was proposed. Among them, AuNRs used as high-efficiency photothermal agent. APP-DOX had suitable size and can be targeted to accumulate in tumour tissues through circulation body. abundant...

Recently, bioinspired material such as nanoparticle has been successfully applied in the cancer therapy. However, how to precisely control drug release from nanomedicine tumor tissue and overcome hypoxic microenvironment of is still an important challenge development nanomedicine. In this work, a new type drug-loaded nanoparticles P(AAm-co-AN)-AuNRs@CeO 2 -DOX (PA-DOX) was prepared by combining high-efficiency photothermal reagents, critical up-conversion temperature polymer layer...

To study the antitumor effect of piceatannol (PIC) on malignant melanoma

Recently, nanomedicine have been successfully applied in the cancer therapy. However, how to precisely control drug release from tumor tissue and overcome hypoxic microenvironment of is still an important challenge development nanomedicine. In this work, a new type drug-loaded nanoparticles P(AAm-co-AN)-AuNRs@CeO2-DOX (PA-DOX) was prepared by combining high-efficiency photothermal reagents, critical up-conversion temperature polymer layer anti-cancer doxorubicin (DOX) for treatment liver...