A5062985370- Advanced MRI Techniques and Applications
- Animal Vocal Communication and Behavior
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Marine animal studies overview
- Animal Behavior and Reproduction
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Physiological and biochemical adaptations
- MRI in cancer diagnosis
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Avian ecology and behavior
- Mesenchymal stem cell research
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Fish Ecology and Management Studies
- Medical Imaging Techniques and Applications
- Medical Image Segmentation Techniques
- Nerve injury and regeneration
- Multiple Sclerosis Research Studies
University of Antwerp
2016-2025
Antwerp University Hospital
2018
University of Colorado Denver
2007-2013
Ghent University
2010-2012
Laboratoire d’Imagerie Biomédicale
2009-2012
Kerckhoff Klinik
2011
TH Köln - University of Applied Sciences
2011
Province of Antwerp
2011
University of Bonn
2011
Maastricht University
2010
Valvular heart disease affects 1%–2% of young individuals, many whom aspire to partake in competitive sport or high intensity recreational exercise. There are limited reports on the impact intensive physical activity progression valvular disease; therefore, current recommendations based consensus opinion. The management exercising individuals with requires a structured approach that incorporates several key factors including symptomatic status, functional capacity, type and nature lesion,...
Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer the possibility to non-invasively probe whole-brain network dynamics and investigate determinants altered signatures observed in human studies. Mouse rsfMRI has been increasingly adopted by numerous laboratories worldwide. Here we describe a multi-centre comparison 17 mouse datasets via common image processing analysis pipeline. Despite prominent cross-laboratory differences equipment procedures,...
Abstract With diffusion tensor imaging, the of water molecules through brain structures is quantified by parameters, which are estimated assuming monoexponential diffusion‐weighted signal attenuation. The however, depend on weighting strength, b ‐value, hampers interpretation and comparison various imaging studies. In this study, a likelihood ratio test used to show that kurtosis model provides more accurate parameterization both Gaussian non‐Gaussian component compared with imaging. As...
At present, resting state functional MRI (rsfMRI) is increasingly used in human neuropathological research. The present study aims at implementing rsfMRI mice, a species that holds the widest variety of neurological disease models. Moreover, by acquiring data with comparable protocol for anesthesia, scanning and analysis, both rats mice we were able to compare findings obtained species. outcome different depends strongly on applied number components Independent Component Analysis (ICA). most...
There is a need for animal models of plaque rupture. We previously reported that elastin fragmentation, due to mutation (C1039G+/−) in the fibrillin-1 (Fbn1) gene, promotes atherogenesis and highly unstable phenotype apolipoprotein E deficient (ApoE−/−) mice on Western-type diet (WD). Here, we investigated whether rupture occurred ApoE−/−Fbn1C1039G+/− was associated with myocardial infarction, stroke, sudden death. Female ApoE−/− were fed WD up 35 weeks. Compared mice, plaques showed...
Purpose The use of resting-state functional MRI (rsfMRI) in preclinical research is expanding progressively, with the majority imaging performed anesthetized animals. Since anesthesia may change physiology and, particular, neuronal activity an animal considerably, it also affect rsfMRI findings. Therefore, this study compared data from awake mice results obtained α-chloralose (120 mg/kg), urethane (2.5 g/kg), or isoflurane (1%). Methods Functional connectivity (FC) was estimated using both...
Abstract Background Cell transplantation is likely to become an important therapeutic tool for the treatment of various traumatic and ischemic injuries central nervous system (CNS). However, in many pre-clinical cell therapy studies, reporter gene-assisted imaging cellular implants CNS potential gene and/or cell-based immunogenicity, still remain challenging research topics. Results In this study, we performed implantation experiments immunocompetent mice using autologous (syngeneic)...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in elderly population. In this study, we used APP/PS1 transgenic mouse model to explore feasibility using diffusion kurtosis imaging (DKI) as tool for early detection microstructural changes brain due amyloid-β (Aβ) plaque deposition. We longitudinally acquired DKI data wild-type (WT) mice at 2, 4, 6 8 months age, after which these were sacrificed histological examination. Three...
Abstract Introduction In Alzheimer's disease (AD), pathologic amyloid‐beta (Aβ) is synaptotoxic and impairs neuronal function at the microscale, influencing brain networks macroscale before Aβ deposition. The latter can be detected noninvasively, in vivo , using resting‐state functional MRI (rsfMRI), a technique used to assess connectivity (FC). Methods RsfMRI was performed longitudinally TG2576 PDAPP mice, starting deposition determine earliest FC changes. Additionally, role of on early...
Copy-number variants of the CYFIP1 gene in humans have been linked to autism spectrum disorders (ASD) and schizophrenia (SCZ), two neuropsychiatric characterized by defects brain connectivity. Here, we show that plays an important role functional connectivity callosal functions. We find Cyfip1-heterozygous mice reduced white matter architecture, similar phenotypes found patients with ASD, SCZ other disorders. Cyfip1-deficient also present decreased myelination axons, altered presynaptic...
Abstract Transgenic mice overexpressing the London mutant of human amyloid precursor protein (APP[V717I]) in neurons develop plaques brain, thus demonstrating most prominent neuropathological hallmark Alzheimer's disease. In vivo 3D T 2 *‐weighted MRI on these (24 months age) revealed hypointense brain inclusions that affected thalamus almost exclusively. Upon correlating observations with a panel different histologic staining techniques, it appeared only were positive for both thioflavin‐S...
Iron, copper and cadmium are determined in brine shrimp specimens using graphite furnace atomic absorption spectrometry. Four different digestion procedures, (i.e., dry ashing, hot-block, high pressure microwave heating digestion) compared. It was concluded that polyethylene autosampler cups is excellent for the rapid dissolution of sub-milligram amounts biological material. Applying platform atomisation peak-area integration, a calibration against acid standards can be used determination...