A5081477699- Cardiac Imaging and Diagnostics
- Ultrasound and Hyperthermia Applications
- Cardiovascular Disease and Adiposity
- Coronary Interventions and Diagnostics
- Pain Management and Treatment
- Acute Myocardial Infarction Research
- Cardiovascular Effects of Exercise
- Photoacoustic and Ultrasonic Imaging
- Cardiovascular Function and Risk Factors
- Tendon Structure and Treatment
- Cardiac Arrhythmias and Treatments
- Laser Applications in Dentistry and Medicine
- Cardiac electrophysiology and arrhythmias
- Coronary Artery Anomalies
- Cerebrovascular and Carotid Artery Diseases
- Kidney Stones and Urolithiasis Treatments
- Nitric Oxide and Endothelin Effects
- Cardiac Health and Mental Health
- Cancer-related molecular mechanisms research
- Medical and Biological Ozone Research
- Urinary Bladder and Prostate Research
- Pulmonary Hypertension Research and Treatments
- S100 Proteins and Annexins
- Heart Failure Treatment and Management
- Ultrasound Imaging and Elastography
Tohoku University
2016-2025
International University of Health and Welfare
2023
Suzuki (Japan)
2017
Massachusetts General Hospital
2017
National Cerebral and Cardiovascular Center
2017
Japan Radioisotope Association
2017
Imperial College London
2017
Hiraka General Hospital
2011
Jichi Medical University
1995
Ferroptosis is an iron-dependent programmed cell death event, whose regulation and physiological significance remain to be elucidated. Analyzing transcriptional responses of mouse embryonic fibroblasts exposed the ferroptosis inducer erastin, here we found that a set genes related oxidative stress protection induced upon ferroptosis. We considered up-regulation these attenuates induction transcription factor BTB domain CNC homolog 1 (BACH1), regulator in heme iron metabolism, promotes by...
Approximately one-half of patients undergoing diagnostic coronary angiography for angina have no significant stenosis, in whom functional abnormalities could be involved. This study examined the significance a comprehensive manner both epicardial and microvascular arteries with nonobstructive artery disease (CAD). prospectively enrolled 187 consecutive (male/female 113/74, 63.2 ± 12.3 years), who underwent acetylcholine provocation test spasm measurement index microcirculatory resistance...
Therapeutic focused-ultrasound to the hippocampus has been reported exert neuroprotective effects on dementia. In present study, we examined whether whole-brain LIPUS (low-intensity pulsed ultrasound) therapy is effective and safe in 2 mouse models of dementia (vascular dementia, VaD Alzheimer's disease, AD), if so, elucidate common underlying mechanism(s) involved.We used bilateral carotid artery stenosis (BCAS) model with micro-coils male C57BL/6 mice as a 5XFAD transgenic an AD model. We...
Background Although a significant progress has been made in the management of ischemic heart disease (IHD), number severe IHD patients is increasing. Thus, it crucial to develop new, non-invasive therapeutic strategies. In present study, we aimed low-intensity pulsed ultrasound (LIPUS) therapy for treatment IHD. Methods and Results We first confirmed that cultured human endothelial cells, LIPUS significantly up-regulated mRNA expression vascular growth factor (VEGF) with peak at 32-cycle...
Objective— Left ventricular (LV) remodeling after acute myocardial infarction still remains an important issue in cardiovascular medicine. We have recently demonstrated that low-intensity pulsed ultrasound (LIPUS) therapy improves ischemia a pig model of chronic through enhanced angiogenesis. In the present study, we aimed to demonstrate whether LIPUS also ameliorates LV and if so, elucidate underlying molecular mechanisms involved beneficial effects LIPUS. Approach Results— examined on...
We are now facing rapid population aging in Japan, which will affect the actual situation of cardiovascular diseases. However, age-specific trends incidence and mortality acute myocardial infarction (AMI) Japan remain to be elucidated.Methods Results:We enrolled a total 27,220 AMI patients (male/female 19,818/7,402) our Miyagi Registry during past 30 years. divided them into 4 age groups (≤59, 60-69, 70-79 ≥80 years) examined temporal in-hospital 3 decades (1985-1994, 1995-2004 2005-2014)....
We have previously demonstrated that low-energy extracorporeal cardiac shock wave (SW) therapy improves myocardial ischemia through enhanced angiogenesis in a porcine model of chronic and patients with refractory angina pectoris. However, the detailed molecular mechanisms for SW-induced remain unclear. In this study, we thus examined effects SW irradiation on intracellular signaling pathways vitro. Cultured human umbilical vein endothelial cells (HUVECs) were treated 800 shots (1 Hz at an...
Abstract Since the treatment window of thrombolytic therapy for stroke is limited, new remains to be developed. We have recently developed low-intensity pulsed ultrasound (LIPUS) improve cognitive dysfunction in mouse models vascular dementia and Alzheimer’s disease. Here, we further aimed examine whether our LIPUS improves neurological recovery from ischemic stroke, if so, elucidate mechanisms involved. In a model middle cerebral artery occlusion (MCAO), applied (32 cycles, 193 mW/cm 2 )...
Background Clinical characteristics and outcomes of patients with myocardial infarction (MI) nonobstructive coronary arteries (MINOCA) are not fully understood, particularly in Japan. Methods Results We enrolled a total 8881 acute MI from the Miyagi Acute Myocardial Infarction Registry Study (2012–2020), median age 69 years. Among them, 239 (2.7%) were diagnosed MINOCA. Compared those obstructive artery disease (MI‐CAD), MINOCA more often women, had higher incidence non–ST‐segment–elevation...
Background:It has been previously demonstrated that extracorporeal low-energy shock-wave (SW) therapy ameliorates left ventricular (LV) remodeling through enhanced angiogenesis after acute myocardial infarction (AMI) in pigs vivo. However, it remains to be examined whether SW also exerts anti-inflammatory effects on AMI.Methods and Results:AMI was created by ligating the proximal anterior descending coronary artery rats. They were randomly assigned 2 groups: with (SW group) or without...
Heart failure with preserved left ventricular ejection fraction (HFpEF) is a serious health problem worldwide, as no effective therapy yet available. We have previously demonstrated that our low-intensity pulsed ultrasound (LIPUS) and safe for angina dementia. In this study, we aimed to examine whether the LIPUS also ameliorates cardiac diastolic dysfunction in mice.
Whether there are prognostic links between coronary morphologies and functional abnormalities was examined in ischemia nonobstructive artery disease (INOCA) patients. Although INOCA has attracted much attention, little is known about the impact of this disorder. A total 329 consecutive patients were enrolled underwent spasm provocation testing combined with lactate sampling for diagnosis epicardial microvascular (MVS). On basis tests, classified into 4 groups: a control group without or MVS...
The prevalence of Alzheimer's disease (AD) has been rapidly increasing worldwide. We have developed a novel angiogenic therapy with low-intensity pulsed ultrasound (LIPUS), which is effective and safe in animal models AD vascular dementia. performed two trials LIPUS for (mild cognitive impairment due to mild AD); roll-in open trial safety, randomized, double-blind, placebo-controlled (RCT) efficacy safety. was whole brain through the bilateral temporal bones one hour 3 times week as session...
Journal Article Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines Get access Takayuki Shindo, Shindo aDepartment of Cardiology Jichi Medical School, Minamikawachi, Tochigi 329-04, Japan Search for other works this author on: Oxford Academic PubMed Google Scholar Uichi Ikeda, Ikeda * *Correspondence to Dr Ikeda. Fujio Ohkawa, Ohkawa Yasuhiro Kawahara, Kawahara bDepartment Internal Medicine, First Division, Kobe University School Kobe, Mitsuhiro Yokoyama,...
Background:The importance of adventitial inflammation has been implicated for the pathogenesis coronary artery disease. However, roles changes in drug-eluting stent (DES)-induced hyperconstriction remain largely unknown. In present study, this issue pigs vivo with a special reference to vasa vasorum (VV) formation and Rho-kinase activation, central mechanism vasospasm, was examined.Methods Results:Each animal received sirolimus-eluting (SES) biolimus A9-eluting (BES), one left anterior...
Chronic left ventricular (LV) pressure overload causes relative ischemia with resultant LV dysfunction. We have recently demonstrated that low-intensity pulsed ultrasound (LIPUS) improves myocardial in a pig model of chronic through enhanced angiogenesis. In the present study, we thus examined whether LIPUS also ameliorates contractile dysfunction pressure-overloaded hearts.Chronic was induced transverse aortic constriction (TAC) mice. applied to whole heart three times first week after TAC...
Pulmonary arterial hypertension is characterized by abnormal proliferation of pulmonary artery smooth muscle cells and vascular remodeling, which leads to right ventricular (RV) failure. Bsg (Basigin) a transmembrane glycoprotein that promotes myofibroblast differentiation, cell proliferation, matrix metalloproteinase activation. CyPA (cyclophilin A) binds its receptor inflammatory recruitment. We previously reported cardiac fibrosis failure in the left ventricle response pressure-overload...
Objective: It remains to be elucidated whether and how endothelial functions are impaired in peripheral circulation of patients with coronary functional disorders, such as vasospastic angina (VSA) microvascular (MVA). We simultaneously examined conduit resistance arteries a special reference NO endothelium-dependent hyperpolarization factors. Approach Results: Based on the results invasive acetylcholine testing physiological measurements, we divided 43 into 3 groups; VSA, MVA, VSA+MVA....
Background:Coronary adventitia harbors a wide variety of components, such as inflammatory cells and vasa vasorum (VV). Adventitial VV initiates the development coronary artery diseases an outside-in supply route inflammation. We have recently demonstrated that drug-eluting stent implantation causes enhancement formation, with extending to edges in porcine arteries, also optical frequency domain imaging (OFDI) is capable visualizing humans vivo. However, it remains be fully validated whether...
An 83-year-old woman with severe aortic stenosis was admitted to our hospital due heart failure refractory anemia requiring blood transfusions. She had repetitive bleeding episodes from endoscopically proven angiodysplasia in the stomach. Moreover, she repeatedly underwent endoscopic argon plasma coagulation for hemostasis. Importantly, a deficiency of high-molecular-weight (HMW) multimers von Willebrand factor (VWF), and diagnosed Heyde's syndrome.After transcatheter valve implantation...
Along with the progress of global aging, prognosis severe ischemic heart disease (IHD) remains poor, and thus development effective angiogenic therapy an important clinical unmet need. We have developed low-energy extracorporeal cardiac shock wave as innovative minimally invasive confirmed its efficacy in a porcine chronic myocardial ischemia model animal experiments well patients refractory angina. Since ultrasound is more advantageous for application than waves, we then aimed to develop...