A5051872145- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolomics and Mass Spectrometry Studies
- Fetal and Pediatric Neurological Disorders
- Neuroscience of respiration and sleep
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Ultrasound and Hyperthermia Applications
- Birth, Development, and Health
- Epilepsy research and treatment
- Photoacoustic and Ultrasonic Imaging
- Alzheimer's disease research and treatments
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Circadian rhythm and melatonin
- Cancer Risks and Factors
- Nanoparticle-Based Drug Delivery
- Heme Oxygenase-1 and Carbon Monoxide
- Ultrasound and Cavitation Phenomena
- MRI in cancer diagnosis
- Neonatal Respiratory Health Research
Norwegian University of Science and Technology
2012-2023
Nordland Hospital Trust
2014
Centre for Sustainable Energy
2009
Summary The objective of this study was to examine a possible association between maternal smoking in pregnancy and childhood overweight. From population‐based cohort 5722 women from Trondheim, Bergen (Norway) Uppsala (Sweden) enrolled early during 1986–92, random sample 482 selected for participation. They were followed up throughout pregnancy, their children birth until 5 years age. Data on diet, socio‐economic determinants breast feeding recorded prospectively. During childhood,...
Increased susceptibility to excitotoxicity of the neonatal brain after hypoxia-ischemia (HI) may be caused by limited capacity astrocytes for glutamate uptake, and mitochondrial failure probably plays a key role in delayed injury cascade. Male infants have poorer outcome than females HI, possibly linked differential intermediary metabolism.[1-(13)C]glucose [1,2-(13)C]acetate were injected at zero, 6, 48 hours unilateral HI 7-day-old rats. Intermediary metabolism was analyzed with magnetic...
Perinatal hypoxia-ischemia is a major cause of acute mortality in newborns and cognitive motor impairments children. Cerebral leads to excitotoxicity necrotic apoptotic cell death, which mitochondria play role. Increased resistance against damage can be achieved by preconditioning triggered subtle insults. CO, toxic molecule that also generated endogenously, may have role as low doses protect inflammation apoptosis. In this study, the CO-induced on neurons was addressed vitro vivo. The...
The neonatal brain is vulnerable to oxidative stress, and the pentose phosphate pathway (PPP) may be of particular importance limit injury. Furthermore, in brain, neurons depend on de novo synthesis neurotransmitters via pyruvate carboxylase (PC) astrocytes increase neurotransmitter pools. In adult PPP activity increases response various injuries while carboxylation reduced after ischemia. However, little known about these pathways hypoxia-ischemia (HI). To this end, 7-day-old rats were...
Real time in vivo detection of Amyloid β (Aβ) deposits at an early stage may lead to faster and more conclusive diagnosis Alzheimer's disease (AD) can facilitate the follow up effect therapeutic interventions. In this work, capability new hybrid nanomaterials target detect Aβ aggregates using magnetic resonance (MRI) fluorescence imaging is demonstrated. These smart contrast agents contain paramagnetic nanoparticles surrounded by luminescent conjugated oligothiophenes (LCOs) known...
Mitochondrial impairment is a key feature underlying neonatal hypoxic-ischemic (HI) brain injury and melatonin potentially neuroprotective through its effects on mitochondria. In this study, we have used (1) H (13) C NMR spectroscopy after injection of [1-(13) C]glucose [1,2-(13) C]acetate to examine neuronal astrocytic metabolism in the early reperfusion phase unilateral HI 7-day-old rat pups, exploring mitochondrial function potential protective metabolism. One hour hypoxia-ischemia, was...
BackgroundNeonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy prematurity. Whether similar oxygen fluctuations will create pathological changes grey and white matter brain unknown. MethodsFrom birth until postnatal day 14 (P14), two litters (total n = 22) were reared IHH: hyperoxia (50% O2) interrupted by three consecutive two-minute episodes hypoxia (12% every sixth hour. Controls (n 8) room-air (20.9% O2). Longitudinal MRI (Diffusion Tensor Imaging...
Abstract Doxycycline may potentially be a neuroprotective treatment for neonatal hypoxic–ischemic brain injury through its anti‐inflammatory effects. The aim of this study was to examine any long‐term neuroprotection by doxycycline on cerebral gray and white matter. Hypoxic–ischemic induced in 7‐day‐old rats. Pups were treated with either (HI+doxy) or saline (HI+vehicle) intraperitoneal injection at 1 h after hypoxia–ischemia (HI). At 6 HI, MnCl 2 injected intraperitoneally later...
Purpose To improve early diagnosis of prostate cancer to aid clinical decision‐making. Diffusion‐weighted magnetic resonance imaging (DW‐MRI) is sensitive water diffusion throughout tissues, which correlates with Gleason score, a histological measure aggressiveness. In this study the ability DW‐MRI detect onset and development was evaluated in transgenic adenocarcinoma mouse (TRAMP) mice. Materials Methods T 2 ‐weighted were acquired using 7T MR scanner, 200 mm bore diameter; 10 TRAMP 6...
<i>Background:</i> Hypoxia-ischemia (HI) in the neonatal brain results a prolonged injury process. Longitudinal studies using noninvasive methods can help elucidate mechanisms behind this We have recently demonstrated that manganese-enhanced magnetic resonance imaging (MRI) depict areas with activated microglia and astrogliosis 7 days after hypoxic-ischemic injury. <i>Objective:</i> The current study aimed to follow HI rats longitudinally compare manganese enhancement...
Melatonin is a promising neuroprotective agent after perinatal hypoxic-ischemic (HI) brain injury. We used in-vivo 1H magnetic resonance spectroscopy to investigate effects of melatonin treatment on metabolism HI. Postnatal day 7 Sprague-Dawley rats with unilateral HI injury were treated either 10 mg/kg dissolved in phosphate-buffered saline (PBS) 5% dimethyl sulfoxide (DMSO) or vehicle (5% DMSO and/or PBS) directly and at 6 hours MR spectra from the thalamus ipsilateral contralateral...
Melatonin has potential neuroprotective capabilities after neonatal hypoxia-ischemia (HI), but long-term effects have not been investigated. We hypothesized that melatonin treatment directly HI could protect against early and delayed brain injury. Unilateral injury was induced in postnatal day 7 rats. An intraperitoneal injection of either or vehicle given at 0, 6 25 hours hypoxia. In-vivo MRI performed 1, 7, 20 43 days HI, followed by histological analysis. Forelimb asymmetry memory were...
Background: Early detection of amyloid-β (Aβ) aggregates is a critical step to improve the treatment Alzheimer’s disease (AD) because neuronal damage by Aβ occurs before clinical symptoms are apparent. We have previously shown that luminescent conjugated oligothiophenes (LCOs), which highly specific towards protein Aβ, can be used fluorescently label amyloid plaque in living rodents. Objective: hypothesize LCO target gadolinium and hence make detectable T 1 -weighted magnetic resonance...
In this study, the effect of a simulated dive on rat brain was investigated using several magnetic resonance imaging (MRI)-methods and immunohistochemistry. Rats were randomly assigned to dive- or control group. The group exposed air 600 kPa for 45 min. Pulmonary artery monitored vascular gas bubbles by ultrasound. MRI performed 1 h after decompression at one 2 weeks with different combination sequences each time point. Two decompression, rats sacrificed brains prepared histology. Dived had...
We designed an NMR-compatible bioreactor that allows real-time metabolic measurements of viable rat brain slices under normal conditions and mimicking hypoxic-ischemic (HI) injury. Special emphasis was put on providing physiological temperature in the system, a significant factor HI model. 1 H NMR spectra were acquired to assess changes metabolites. Peaks lactic acid, NAA, glutamate, aspartate, creatine detected. By acquiring time series proton spectra, we observed significantly increased...