A5085751036- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Bariatric Surgery and Outcomes
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Gastrointestinal motility and disorders
- Multiple Myeloma Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Gastrointestinal Tumor Research and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Immunotherapy and Immune Responses
- Clinical Nutrition and Gastroenterology
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Neuropeptides and Animal Physiology
- Chronic Lymphocytic Leukemia Research
- Alkaloids: synthesis and pharmacology
- Effects of Environmental Stressors on Livestock
- RNA Interference and Gene Delivery
Oita Prefectural Hospital
2023-2024
Norwegian University of Science and Technology
2010-2024
Kitasato University
2018-2022
Akashi Municipal City Hospital
1999
Iwate University
1999
Gifu University
1972
Sapporo Medical University
1966
Surgical or pharmacologic interruption of muscarinic innervation to the stomach suppresses gastric tumor growth in mice and humans.
Cancer cells can develop an attenuated immunogenicity and/or create immunosuppressive microenvironment to prevent tumor eradication by host immune system, the so-called "cancer immunoediting" hypothesis. The aim of present study was find evidence for this hypothesis using a rat orthotopic bladder cancer model. Fisher rats were inoculated with AY-27 (a cell line). Cultured cells, and human tissues, publicly available microarray data from analyzed means bioinformatics morphology. Results...
Abstract Biomarkers associated with the progression from gastric intestinal metaplasia (GIM) to adenocarcinoma (GA), i.e., GA-related GIM, could provide valuable insights into identifying patients increased risk for GA. The aim of this study was utilize multi-bioinformatics reveal potential biomarkers GIM and predict drug repurposing GA prevention in patients. included gene expression matrix (GEM) by microarray (MGE), ScType (a fully automated ultra-fast cell-type identification based solely...
The effects of feed restriction, cold exposure, and the initiation feeding on blood glucose metabolism, other metabolites, hormones, tissue responsiveness sensitivity to insulin were measured in sheep. sheep consumed orchardgrass hay ad libitum (AL) or restricted 82% ME requirement for maintenance (RE) exposed a thermoneutral (20°C) environment (2°C). An isotope dilution method clamp approach applied determine metabolism action, respectively. Plasma NEFA concentrations influenced by...
Autophagy has dual roles in tumorigenesis: tumor-promoting or tumor-suppressing. The aim of the present study was to examine autophagy-related markers by immunohistochemistry gastric carcinoids and adenocarcinomas rodent models patients.Gastric Mastomys were induced loxtidine treatment. Spontaneously developed Japanese cotton rats INS-GAS transgenic mice included. Patient tissue samples collected. Immunohistochemistry performed against gene protein-6 (ATG-6, also called beclin-1), ATG-5...
Naturally occurring isothiocyanates (ITCs) from edible vegetables have shown potential as chemopreventive agents against several types of cancer. The aims the present study were to ITCs in chemoprevention and potentiating efficacy cytotoxic drugs gastric cancer treatment. was studied chemically induced mouse model cancer, namely N-methyl-N-nitrosourea (MNU) drinking water, a genetically engineered (the so-called INS-GAS mice). pharmacological effects with or without cisplatin human cell...
Abstract Background and Aim: Application of acetic acid topically to the mucosal or serosal side stomach has been well used create a chronic gastric ulcer model. The aim present study was apply it as new cytoreductive approach in mouse model cancer. Methods: A total 43 genetically engineered mice, so‐called (INS‐GAS) mice that develop spontaneously cancer at 10–14 months age, were included. Acetic acid‐induced method applied under isofluran anesthesia. made by exposing either anterior...
Food intake, eating behavior, and metabolic parameters in rats that underwent bilateral truncal vagotomy, sleeve gastrectomy, duodenal switch procedures were examined.
Background Both gastric bypass (GB) and duodenal switch with sleeve gastrectomy (DS) have been widely used as bariatric surgeries, DS appears to be superior GB. The aim of this study was better understand the mechanisms leading body weight loss by comparing these two procedures in experimental models rats. Methods Animals were subjected GB, or laparotomy (controls), monitored an open-circuit indirect calorimeter composed comprehensive laboratory animal monitoring system adiabatic bomb...
We investigated the effect of increased pH induced by acid suppressants on viability non-Helicobacter pylori helicobacters (NHPHs) within parietal cell intracellular canaliculi and fundic glandular lumina immunohistochemistry, electron microscopy, quantitative PCR, urea breath tests, using a bilayer culture system. Three months before experiment, mice were infected with NHPH H. suis then treated famotidine (2 mg/kg body weight [BW], once daily), lansoprazole (30 BW, or vonoprazan (20 daily)...
A combined procedure of sleeve gastrectomy and duodenal switch (SG+DS) has been applied to the treatment super obesity. The aim present study was test whether alone (DS) leads similar weight loss changes in lipid metabolism as SG+DS.Male Sprague-Dawley rats underwent sham surgery (Sham, N=7), (DS, N=5) or followed by (SG+DS, N=5). Body weight, feed water intakes, ambulatory activity were recorded 2 months post surgery. Tissue faecal lipids, bile acids, plasma cytokines metabolism-related...
A 66-year-old man was diagnosed with symptomatic IgG-λ multiple myeloma based on the presence of anemia, thrombocytopenia, renal dysfunction, and a tumor right sixth rib. Bone marrow aspiration yielded dry tap biopsy revealed myelofibrosis grade 2. Partial response achieved Bd (bortezomib dexamethasone) VRd (bortezomib, lenalidomide, dexamethasone). The patient received autologous stem cell transplantation, but relapsed 3 months later, liver tumors developed as well. DKd (daratumumab,...