David Dopfel
A5066323373- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
Pennsylvania State University
2018-2023
Millennium Engineering and Integration (United States)
2022
Only a minority of individuals experiencing trauma subsequently develop post-traumatic stress disorder (PTSD). However, whether differences in vulnerability to PTSD result from predisposition or exposure remains unclear. A major challenge differentiating these possibilities is that clinical studies focus on already exposed without pre-trauma conditions. Here, using the predator scent model rats and longitudinal design, we measure brain-wide neural circuit functional connectivity, behavioral...
Rodent models are essential to translational research in health and disease. Investigation rodent brain function organization at the systems level using resting-state functional magnetic resonance imaging (rsfMRI) has become increasingly popular. Due this rapid progress, publicly shared rsfMRI databases can be of particular interest importance scientific community, as inspired by human neuroscience psychiatric that substantially facilitated open neuroimaging datasets. However, such rats...
Abstract The default mode network (DMN) is a principal brain in the mammalian brain. Although DMN humans has been extensively studied with respect to structure, function, and clinical implications, our knowledge of animals remains limited. In particular, functional role nodes, how organization relates DMN-relevant behavior are still elusive. Here we investigated causal relationship inactivating pivotal node (i.e., dorsal anterior cingulate cortex [dACC]) on organization, by combining...
Abstract Task-free functional connectivity in animal models provides an experimental framework to examine phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, acquisitions are performed varying protocols analyses that hamper result integration. We introduce StandardRat , a consensus rat MRI acquisition protocol tested across 20 centers. develop this optimized processing parameters, we initially aggregated 65 imaging datasets acquired rats...
Abstract Only a minority of individuals who experience traumatic event(s) subsequently develop post-traumatic stress disorder (PTSD). However, whether differences in vulnerability to PTSD result from predisposition or consequence trauma exposure remains unclear. A major challenge differentiating these possibilities is that clinical studies focus on already exposed experiences, and do not take into account pre-trauma conditions. Here using the predator scent model rats longitudinal design, we...
Abstract Rodent models are essential to translational research in health and disease. Investigation rodent brain function organization at the systems level using resting-state functional magnetic resonance imaging (rsfMRI) has become increasingly popular, owing its high spatial resolution whole-brain coverage. Due this rapid progress, shared rsfMRI databases can be of particular interest importance scientific community, as inspired by human neuroscience psychiatric that substantially...