Milou Straathof
A5039656500- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Maternal Mental Health During Pregnancy and Postpartum
- Neonatal and fetal brain pathology
- Medical Imaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Eating Disorders and Behaviors
- EEG and Brain-Computer Interfaces
- Chemical Reactions and Isotopes
- Acute Ischemic Stroke Management
- Anesthesia and Neurotoxicity Research
- Spinal Dysraphism and Malformations
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Attachment and Relationship Dynamics
- Regulation of Appetite and Obesity
- Migraine and Headache Studies
- Infant Development and Preterm Care
- Amyotrophic Lateral Sclerosis Research
Amsterdam University Medical Centers
2024
Amsterdam Neuroscience
2022-2024
University of Amsterdam
2022-2024
University Medical Center Utrecht
2016-2023
Utrecht University
2018-2023
Heidelberg University
2022
University Hospital Heidelberg
2022
Abstract While animal studies have demonstrated a unique reproduction-related neuroplasticity, little is known on the effects of pregnancy human brain. Here we investigated whether associated with changes to resting state brain activity, white matter microstructure, neural metabolite concentrations and grey architecture using comprehensive pre-conception cohort study. We show that leads selective robust in network organization, which are most pronounced Default Mode Network. These correlated...
<h3>Background</h3> In patients with a <i>C9orf72</i> repeat expansion (C9+), neuroimaging phenotype widespread structural cerebral changes has been found. We aimed to investigate the specificity of this in amyotrophic lateral sclerosis (ALS). <h3>Methods</h3> 156 C9− and 14 C9+ ALS underwent high-resolution T1-weighted MRI; subset (n=126) diffusion-weighted imaging. Cortical thickness, subcortical volumes white matter integrity were compared between patients. Using elastic net logistic...
Animal studies have shown that pregnancy is associated with neural adaptations promote maternal care. The hypothalamus represents a central structure of the mammalian brain and hormonal priming specific hypothalamic nuclei plays key role in induction expression behavior. In humans, we previously demonstrated becoming mother involves changes grey matter anatomy, primarily association areas cerebral cortex. current study, investigated whether renders anatomical hypothalamus. Using an advanced...
Recanalization therapy after acute ischemic stroke enables restoration of cerebral perfusion. However, a significant subset patients has poor outcome, which may be caused by disruption energy metabolism. To assess changes in glucose metabolism subacutely and chronically recanalization, we applied two complementary imaging techniques, fluorodeoxyglucose (FDG) positron emission tomography (PET) deuterium ( 2 H) metabolic (DMI), 60-minute transient middle artery occlusion (tMCAO) C57BL/6 mice....
An improved understanding of the structure-function relationship in brain is necessary to know what degree structural connectivity underpins abnormal functional seen disorders. We integrated high-field resting-state fMRI-based with high-resolution macro-scale diffusion-based and meso-scale neuronal tracer-based connectivity, obtain an accurate depiction rat brain. Our main goal was identify extent strengths are correlated, macro- meso-scopically, across cortex. Correlation analyses revealed...
Abstract Task-free functional connectivity in animal models provides an experimental framework to examine phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, acquisitions are performed varying protocols analyses that hamper result integration. We introduce StandardRat , a consensus rat MRI acquisition protocol tested across 20 centers. develop this optimized processing parameters, we initially aggregated 65 imaging datasets acquired rats...
Abstract Eating disorders and obesity form a major health problem in Western Society. To be able to provide adequate treatment prevention, it is necessary understand the neural mechanisms underlying development of eating obesity. Specific brain networks have been shown involved feeding behavior. We therefore hypothesized that functional connectivity behavior dependent on status homeostatic energy balance, thus being hungry or satiated. test our hypothesis, we measured amplitudes signals...
Abstract Transcranial direct current stimulation (tDCS) is a noninvasive brain technique implicated as promising adjunct therapy to improve motor function through the neuromodulation of networks. Particularly bilateral tDCS, which affects both hemispheres, may yield stronger effects on learning than unilateral stimulation. Therefore, aim this exploratory study was develop an experimental model for simultaneous magnetic resonance imaging (MRI) and tDCS in rats, measure instant resultant...
Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment.Our goal was to characterize acute chronic effect of memantine treatment on compulsive behavior network structure function in adolescent rat model compulsivity.Juvenile Sprague-Dawley rats received repeated quinpirole, resulting checking (n = 32; compulsive) or saline...
Background. Recovery of motor function after stroke appears to be related the integrity axonal connections in corticospinal tract (CST) and corpus callosum, which may both affected cortical stroke. Objective. In present study, we aimed elucidate relationship changes measures CST transcallosal integrity, with interhemispheric functional connectivity sensorimotor performance experimental Methods. We conducted vivo diffusion magnetic resonance imaging (MRI), resting-state MRI, behavior testing...
Abstract An improved understanding of the structure-function relationship in brain is necessary to know what degree structural connectivity underpins abnormal functional seen many disorders. We integrated high-field resting-state fMRI-based with high-resolution macro-scale diffusion-based and meso-scale neuronal tracer-based connectivity, obtain an accurate depiction rat brain. Our main goal was identify extent strengths are correlated, macro- meso-scopically, across cortex. Correlation...