A5010214750- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Fetal and Pediatric Neurological Disorders
- EEG and Brain-Computer Interfaces
- Mental Health Research Topics
- Statistical Methods in Clinical Trials
- Meta-analysis and systematic reviews
- Epilepsy research and treatment
- Folate and B Vitamins Research
- Child and Adolescent Psychosocial and Emotional Development
- Liver Disease Diagnosis and Treatment
- Health and Medical Research Impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Cardiac Health and Mental Health
- Alcohol Consumption and Health Effects
- Health Systems, Economic Evaluations, Quality of Life
- Action Observation and Synchronization
- Blind Source Separation Techniques
- Multisensory perception and integration
Utrecht University
2017-2021
University Medical Center Utrecht
2016-2021
Weatherford College
2020
Heidelberg University
2018
University Hospital Heidelberg
2018
Amsterdam Public Health
2016
Vrije Universiteit Amsterdam
2013
Diffusion MRI (dMRI)-based tractography offers unique abilities to map whole-brain structural connections in human and animal brains. However, dMRI-based indirectly measures white matter tracts, with suboptimal accuracy reliability. Recently, sophisticated methods including constrained spherical deconvolution (CSD) global have been developed improve tract reconstructions through modeling of more complex fiber orientations. Our study aimed determine the connectome reconstruction for three...
Background There is a paucity of valid, brief instruments for the assessment lifetime major depressive disorder (MDD) that can be used in, example, large-scale genomics, imaging or biomarker studies on depression. We developed LIfetime Depression Assessment Self-report (LIDAS), which assesses MDD diagnosis according to DSM criteria, and largely based widely Composite International Diagnostic Interview (CIDI). Here, we tested feasibility determined sensitivity specificity measuring with this...
Functional outcome after stroke depends on the local site of ischemic injury and remote effects within connected networks, frequently extending into contralesional hemisphere. However, pattern large-scale network remodeling remains largely unresolved. In this study, we applied diffusion-based tractography graph-based analysis to measure structural connectivity in hemisphere chronically experimental rats. We used minimum spanning tree method, which accounts for variations density, unbiased...
An improved understanding of the structure-function relationship in brain is necessary to know what degree structural connectivity underpins abnormal functional seen disorders. We integrated high-field resting-state fMRI-based with high-resolution macro-scale diffusion-based and meso-scale neuronal tracer-based connectivity, obtain an accurate depiction rat brain. Our main goal was identify extent strengths are correlated, macro- meso-scopically, across cortex. Correlation analyses revealed...
Despite clinical symptoms, a large majority of people with mild traumatic brain injury (TBI) have normal computed tomography (CT) and magnetic resonance imaging (MRI) scans. Therefore, present-day neuroimaging tools are insufficient to diagnose or classify low grades TBI. Advanced techniques, such as diffusion-weighted functional MRI, may yield novel biomarkers that aid in the diagnosis present study had two aims: first, characterize development MRI-based measures structural changes gray...
Abstract Epilepsy is largely under-diagnosed in low-income and middle-income countries, due to lack of medical specialists expensive electroencephalography (EEG) hardware. In this study we investigate if low-cost consumer-grade EEG combination with machine learning techniques can offer a reliable screening tool improve diagnosis rates. We acquired brain signals people epilepsy (N=163) healthy controls (N=138) two difficult-to-reach areas rural Guinea-Bissau Nigeria. Five minutes fourteen...
Background. Recovery of motor function after stroke appears to be related the integrity axonal connections in corticospinal tract (CST) and corpus callosum, which may both affected cortical stroke. Objective. In present study, we aimed elucidate relationship changes measures CST transcallosal integrity, with interhemispheric functional connectivity sensorimotor performance experimental Methods. We conducted vivo diffusion magnetic resonance imaging (MRI), resting-state MRI, behavior testing...
Abstract An improved understanding of the structure-function relationship in brain is necessary to know what degree structural connectivity underpins abnormal functional seen many disorders. We integrated high-field resting-state fMRI-based with high-resolution macro-scale diffusion-based and meso-scale neuronal tracer-based connectivity, obtain an accurate depiction rat brain. Our main goal was identify extent strengths are correlated, macro- meso-scopically, across cortex. Correlation...
Abstract Background Biomedical studies with low statistical power are a major concern in the scientific community and one of underlying reasons for reproducibility crisis science. If randomized clinical trials, which considered backbone evidence-based medicine, also suffer from power, this could affect medical practice. Methods We analysed 137 032 trials between 1975 2017 extracted meta-analyses Cochrane database systematic reviews. determined study to detect standardized effect sizes...
Abstract Prolonged auditory sensory deprivation leads to brain reorganization, indicated by functional enhancement in remaining systems, a phenomenon known as cross-modal plasticity. In this study we investigated differences network shifts from eyes-closed eyes-open conditions between deaf and hearing people. Electroencephalography activity was recorded (N = 71) people 122) living rural Africa, which yielded unique data-set of congenital, pre-lingual post-lingual people, with divergent...