A5082938283- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Bioinformatics and Genomic Networks
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Gene expression and cancer classification
- Advanced MRI Techniques and Applications
- Fractal and DNA sequence analysis
- Child and Animal Learning Development
- Fetal and Pediatric Neurological Disorders
- Health, Environment, Cognitive Aging
- Migraine and Headache Studies
- Zebrafish Biomedical Research Applications
- Tryptophan and brain disorders
- Neurobiology and Insect Physiology Research
- Cognitive Abilities and Testing
- Single-cell and spatial transcriptomics
- Genetic Associations and Epidemiology
- Hemispheric Asymmetry in Neuroscience
- Primate Behavior and Ecology
- Statistical Methods and Inference
Vrije Universiteit Amsterdam
2019-2023
Amsterdam Neuroscience
2019-2023
Utrecht University
2017
University of British Columbia
2017
University Medical Center Utrecht
2017
Abstract Cognitive brain networks such as the default-mode network (DMN), frontoparietal network, and salience are key functional of human brain. Here we show that rapid evolutionary cortical expansion cognitive in brain, most pronounced DMN, runs parallel with high expression human-accelerated genes (HAR genes). Using comparative transcriptomics analysis, present HAR differentially more expressed higher-order humans compared to chimpanzees macaques DMN involved synapse dendrite formation....
The development of complex cognitive functions during human evolution coincides with pronounced encephalization and expansion white matter, the brain's infrastructure for region-to-region communication. We investigated adaptations macroscale brain network by comparing wiring that chimpanzee, one our closest living primate relatives. White matter connectivity networks were reconstructed using diffusion-weighted MRI in humans (
The parcellation of the brain's cortical surface into anatomically and/or functionally distinct areas is a topic ongoing investigation and interest. We provide digital versions six classical human brain atlases in common MRI space. represent range modalities, including cyto- myeloarchitecture (Campbell, Smith, Brodmann Von Economo), myelogenesis (Flechsig), mappings symptomatic information relation to spatial location lesions (Kleist). Digital reconstructions these important widen modalities...
Abstract Brains come in many shapes and sizes. Nature has endowed big-brained primate species like humans with a proportionally large cerebral cortex. Comparative studies have suggested, however, that the total volume allocated to white matter connectivity—the brain’s infrastructure for long-range interregional communication—does not keep pace We investigated consequences of this allometric scaling on brain connectivity network organization. collated structural diffusion magnetic resonance...
Psychiatric conditions show overlap in their symptoms, genetics, and involvement brain areas circuits. Structural alterations the have been found to run parallel with expression profiles of risk genes at level transcriptome, which may point toward a potential transdiagnostic vulnerability disease processes. We characterized transcriptomic cortex across 4 major psychiatric disorders based on collated data from patients (n = 390) matched control participants 293). compared normative linked...
Abstract Multiscale integration of gene transcriptomic and neuroimaging data is becoming a widely used approach for exploring the molecular underpinnings large‐scale brain organization in health disease. Proper statistical evaluation determined associations between imaging‐based phenotypic key these explorations, particular to establish whether observed exceed “chance level” random, nonspecific effects. Recent approaches have shown importance models that can correct spatial autocorrelation...
A long-standing topic of interest in human neurosciences is the understanding neurobiology underlying cognition. Less commonly considered to what extent such systems may be shared with other species. We examined individual variation brain connectivity context cognitive abilities chimpanzees (n = 45) and humans search a conserved link between cognition across two Cognitive scores were assessed on variety behavioral tasks using chimpanzee- human-specific test batteries, measuring aspects...
Large-scale comparative neuroscience requires data from many species and, ideally, at multiple levels of description. Here, we contribute to this endeavor by presenting diffusion and structural MRI eight primate that have not or rarely been described in the literature. The selected samples Primate Brain Bank cover a prosimian, New Old World monkeys, great ape. We present preliminary labelling cortical sulci tractography optic radiation, dorsal part cingulum bundle, parietal-frontal ventral...
Mammalian brains constitute complex organized networks of neural projections. On top their binary topological organization, the strength (or weight) these projections can be highly variable across connections and is thus likely additional importance to overall functional organization network. Here we investigated specific distribution pattern connection in macaque connectome. We performed weighted network analysis on cortico-cortical connectivity provided by unique tract-tracing dataset...
Abstract Transcranial direct current stimulation (tDCS) is a noninvasive brain technique implicated as promising adjunct therapy to improve motor function through the neuromodulation of networks. Particularly bilateral tDCS, which affects both hemispheres, may yield stronger effects on learning than unilateral stimulation. Therefore, aim this exploratory study was develop an experimental model for simultaneous magnetic resonance imaging (MRI) and tDCS in rats, measure instant resultant...
Abstract Multiscale integration of gene transcriptomic and neuroimaging data is becoming a widely used approach for exploring the molecular underpinnings large-scale brain structure function. Proper statistical evaluation computed associations between imaging-based phenotypic key in these explorations, particular to establish whether observed exceed ‘chance level’ random, non-specific effects. Recent approaches have shown importance spatial null models test specificity effects avoid serious...
Abstract Brains come in many shapes and sizes. Nature has endowed big-brained primate species like humans with a proportionally large cerebral cortex. White matter connectivity – the brain’s infrastructure for long-range communication might not always scale at same pace as We investigated consequences of this allometric scaling white brain network connectivity. Structural T1 diffusion MRI data were collated across fourteen species, describing comprehensive 350-fold range volume. report...
Abstract Cognitive functional networks such as the default-mode network (DMN), frontal-parietal (FPN), and salience (SN), are key of human brain. Here, we show that distinct rapid evolutionary cortical expansion cognitive in brain, most pronounced DMN, runs parallel with high expression genes important for evolution (so-called HAR genes). Comparative gene examination then shows more differentially expressed humans compared to chimpanzee macaque. Genes DMN display broad involvement formation...