A5015563036- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Child and Adolescent Psychosocial and Emotional Development
- Digital Mental Health Interventions
- Evolutionary Psychology and Human Behavior
- Neuroscience and Music Perception
- Tryptophan and brain disorders
- Impact of Technology on Adolescents
- Stress Responses and Cortisol
- Advanced MRI Techniques and Applications
- Neuroscience of respiration and sleep
- Neural and Behavioral Psychology Studies
- Treatment of Major Depression
- Health, Environment, Cognitive Aging
- Attachment and Relationship Dynamics
- Perfectionism, Procrastination, Anxiety Studies
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Sleep and Work-Related Fatigue
- COVID-19 and Mental Health
- Subtitles and Audiovisual Media
- Blood Pressure and Hypertension Studies
Karolinska Institutet
2016-2025
Babeș-Bolyai University
2024-2025
Stockholm Health Care Services
2019-2024
Max Planck Institute for Human Development
2019-2022
Prostate Cancer Research
2020-2022
University College London
2020-2022
Stockholm University
2017-2021
Max Planck Institute for Biology of Ageing
2020-2021
Dartmouth College
2021
Stockholm County Council
2019-2020
Psychological treatments provide many benefits for patients with psychiatric disorders, but research also suggests that negative effects might occur from the interventions involved. The Negative Effects Questionnaire (NEQ) has previously been developed as a way of determining occurrence and characteristics such incidents, consisting 32 items six factors. However, NEQ yet to be examined using modern test theory, which could help improve understanding how well instrument works...
Abstract Cognitive behavior therapy (CBT) is an effective treatment for social anxiety disorder (SAD), but many patients do not respond sufficiently and a substantial proportion relapse after has ended. Predicting individual’s long-term clinical response therefore remains important challenge. This study aimed at assessing neural predictors of outcome in participants with SAD 1 year completion Internet-delivered CBT (iCBT). Twenty-six diagnosed underwent iCBT including attention bias...
Abstract Patients with anxiety disorders exhibit excessive neural reactivity in the amygdala, which can be normalized by effective treatment like cognitive behavior therapy (CBT). Mechanisms underlying brain’s adaptation to anxiolytic treatments are likely related both structural plasticity and functional response alterations, but multimodal neuroimaging studies addressing structure–function interactions currently missing. Here, we examined treatment-related changes brain structure (gray...
Evidence-based psychological treatments, such as cognitive behavior therapy (CBT), have been found to be effective in treating several anxiety and mood disorders. Nevertheless, issues regarding adherence are common, poor patient compliance on homework assignments therapists' drifting from strictly evidence-based CBT. The development of Internet-delivered CBT (ICBT) has intensive the past decade results show that guided ICBT can face-to-face but also indicate a need integrate two forms...
Abstract Background There are no consistent predictors of treatment outcome in paediatric obsessive–compulsive disorder (OCD). One reason for this might be the use suboptimal statistical methodology. Machine learning is an approach to efficiently analyse complex data. has been widely used within other fields, but rarely tested prediction mental health outcomes. Objective To test four different machine methods response a sample OCD patients who had received Internet‐delivered cognitive...
Background and Aims Internet-based cognitive-behavioral therapy (iCBT) for social anxiety disorder has been found effective, as attested by independently conducted randomized controlled trials in four languages. The study aim is to test the efficacy of an iCBT program a culture where it was not tested before (i.e. Romania). Methods Participants (n = 76) were recruited, screened either nine-week guided or wait-list control group April May 2012. Self-report measures collected (April 2012)...
Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric co-morbidity. Previous research on structural brain alterations SAD has yielded inconsistent results concerning the direction of changes in gray matter (GM) various regions, as well relationship between structure SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multi-site imaging offers new opportunities investigate SAD-related larger...
Highlights•Overt surpassed covert SSRI treatment with doubled effect size and tripled response rate on the main social anxiety outcome.•Overt vs. yielded different neural changes in brain areas involved emotion-cognition interactions.•This study suggests that presentation of a may be as important itself.Using truthful or deceiving verbal instructions, we tested how expectancies influence efficacy disorder. The number responders was more than three times higher after open administration...
Understanding the association between autonomic nervous system [ANS] function and brain morphology across lifespan provides important insights into neurovisceral mechanisms underlying health disease. Resting-state ANS activity, indexed by measures of heart rate [HR] its variability [HRV] has been associated with morphology, particularly cortical thickness [CT]. While findings have mixed regarding anatomical distribution direction associations, these inconsistencies may be due to sex age...
Social anxiety disorder (SAD) can come in different forms, presenting problems for diagnostic classification. Here, we examined personality traits a large sample of patients (N = 265) diagnosed with SAD comparison to healthy controls 164) by use the Revised NEO Personality Inventory (NEO-PI-R) and Karolinska Scales (KSP). In addition, identified subtypes based on cluster analysis NEO-PI-R Big Five dimensions. Significant group differences between were noted all dimensions except...
Biomarkers of psychiatric treatment response remain elusive. Functional magnetic resonance imaging (fMRI) has shown promise, but low reliability limited the utility typical fMRI measures (e.g., average brain signal) as harbingers success. Notably, although historically considered a source noise, temporal signal variability continues to gain momentum sensitive and reliable indicator individual differences in neural efficacy, yet not been examined relation outcomes.A total 45 patients with...
Individuals with social anxiety disorder (SAD) experience overall emotion regulation difficulties, but less is known about the long-term role of such difficulties in cognitive behavior therapy (CBT) for SAD. Forty-six patients SAD receiving internet-delivered CBT, and matched healthy controls (HCs;
Abstract Depression is one of the most common psychiatric conditions. Given its high prevalence and disease burden, accurate diagnostic procedures valid instruments are warranted to identify those in need treatment. The Patient Health Questionnaire-9 (PHQ-9) widely used self-report measures depression, validity reliability has been evaluated several languages. However, Swedish translation yet not subject psychometric evaluation, no previous evaluation instrument have both Rasch analysis...
Background. Deficits in social behaviors have been suggested as a promising treatment target for psychiatric disorders. While context influences prosocial behavior healthy individuals, its role the development of disorders remains unclear. We hypothesized that situation-specific would predict long-term symptoms individuals with common Method. In 1-year longitudinal cohort study (n = 4484 at baseline), we followed population sample self-reported to investigate if six subtypes were associated...
Abstract It has been extensively debated whether selective serotonin reuptake inhibitors (SSRIs) are more efficacious than placebo in affective disorders, and it is not fully understood how SSRIs exert their beneficial effects. Along with transporter blockade, altered dopamine signaling psychological factors may contribute. In this randomized clinical trial of participants social anxiety disorder (SAD) we investigated manipulation verbally-induced expectancies, vital for response, affect...
Hoarding disorder (HD) is difficult to treat. In an effort increase efficacy and engagement in cognitive-behavioral therapy (CBT), we developed evaluated a novel intervention comprising group CBT combined with between-session Internet-based clinician support for people HD.Twenty participants HD received Internet-support system enabling therapist-participant communication between sessions.The treatment was associated significant reduction on the Saving Inventory-Revised (SI-R) large effect...
Background: Parkinson's disease (PD) is often associated with psychological distress and lowered daily functioning.The availability of interventions tailored for people Parkinson very limited.Objective: To study if guided individually-tailored internet-based cognitive behavioral therapy (ICBT) provide additional value to standard medical treatment PD.Methods: Seventy-seven individuals PD self-reported problems general function measured the Work Social Adjustment Scale (WSAS > 15) were...