David Hofmann
A5055374737- Functional Brain Connectivity Studies
- Traumatic Brain Injury Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Posttraumatic Stress Disorder Research
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Music Perception
- Anesthesia and Neurotoxicity Research
- Vestibular and auditory disorders
- Memory and Neural Mechanisms
- Child Abuse and Trauma
- Psychosomatic Disorders and Their Treatments
- Hearing Loss and Rehabilitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Stress Responses and Cortisol
- Face Recognition and Perception
- Health, Environment, Cognitive Aging
- EEG and Brain-Computer Interfaces
- Neuroscience of respiration and sleep
- Resilience and Mental Health
- Neonatal and fetal brain pathology
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced MRI Techniques and Applications
University of Münster
2018-2024
Humboldt-Universität zu Berlin
2024
Ghent University Hospital
2023
University of Illinois Chicago
2023
University of Cape Town
2023
Leiden University Medical Center
2022
University Hospital Münster
2018-2021
Universitätsklinikum Würzburg
2020
Current theories of visual consciousness disagree about whether it emerges during early stages processing in sensory brain regions or later when a widespread frontoparietal network becomes involved. Moreover, disentangling conscious perception from task-related postperceptual processes (e.g., report) and integrating results across different neuroscientific methods remain ongoing challenges. The present study addressed these problems using simultaneous EEG-fMRI specific inattentional...
Abstract The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging children adults (5–90...
Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates brain age, compared to chronological may clarify the effects PTSD on and inform treatment approaches targeting neurobiology aging in context PTSD.Adult subjects (N = 2229; 56.2% male) aged 18-69 years (mean 35.6, SD 11.0) from 21 ENIGMA-PGC sites underwent T1-weighted structural magnetic resonance imaging, assessment (PTSD+, n 884). Previously trained voxel-wise (brainageR) region-of-interest...
Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants' demographic and clinical characteristics, as well MRI acquisition protocols scanning platforms. We compared the impact four different harmonization methods on results obtained analyses cortical thickness data: (1) linear mixed-effects model (LME) that models random intercepts (LME
Anticipation of potentially threatening social situations is a key process in anxiety disorder (SAD). In other disorders, recent research neural correlates anticipation temporally unpredictable threat suggests dissociable involvement amygdala and bed nucleus the stria terminalis (BNST) with phasic responses sustained BNST activation. However, temporal profile during unpredictability has not been investigated patients suffering from SAD. We used functional magnetic resonance imaging (fMRI) to...
Recent advances in data-driven computational approaches have been helpful devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited small homogeneous samples, different methodologies, and imaging collection protocols, limit the ability directly compare generalize their results. Here we aimed classify individuals with PTSD versus controls assess generalizability using a large heterogeneous brain datasets from ENIGMA-PGC Working group. We...
Abstract The bed nucleus of the stria terminalis (BNST) and laterobasal (LB), centromedial (CM), superficial (SF) amygdala form an interconnected dynamical system, whose combined activity mediates a variety behavioral autonomic responses in reaction to homeostatic challenges. Although previous research provided deeper insight into structural functional connections between these nuclei, studies investigating their resting‐state magnetic resonance imaging (fMRI) connectivity were solely based...
Neural mismatch responses have been proposed to rely on different mechanisms, including prediction error-related activity and adaptation frequent stimuli. However, the hierarchical cortical structure of these mechanisms is unknown. To investigate this question, we recorded hemodynamic while participants (N = 54) listened an auditory oddball sequence as well a suited control condition. In addition effects in sensory processing areas (Heschl's gyrus, superior temporal gyrus (STG)), found...
Abstract A growing number of studies have examined alterations in white matter organization people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results been mixed, which may be partially due to relatively small sample sizes among studies. Altered structural connectivity both a neurobiological vulnerability for, and result of, PTSD. In an effort find reliable effects, we present multi-cohort analysis dMRI metrics across 3,049 individuals from 28 cohorts...
Abstract Despite considerable effort, the neural correlates of altered threat-related processing in panic disorder (PD) remain inconclusive. Mental imagery disorder-specific situations proved to be a powerful tool investigate dysfunctional threat anxiety disorders. The current functional magnetic resonance imaging (fMRI) study aimed at investigating brain activation PD patients during disorder-related script-driven imagery. Seventeen and seventeen healthy controls (HC) were exposed newly...
In a previous study, we investigated the resting-state fMRI effective connectivity (EC) between bed nucleus of stria terminalis (BNST) and laterobasal (LB), centromedial (CM), superficial (SF) amygdala. We found strong negative EC from all amygdala nuclei to BNST, while BNST showed positive However, validity these findings remains unclear, since reproduction in different samples has not been done. Moreover, association with measures anxiety offers deeper insight, due known role fear anxiety....
Abstract Background PTSD and depression commonly co-occur have been associated with smaller hippocampal volumes compared to healthy trauma-exposed controls. However, the hippocampus is heterogeneous, subregions that may be uniquely affected in individuals depression. Methods We used random effects regressions a harmonized neuroimaging protocol based on FreeSurfer (v6.0) identify sub-structural markers of current (C-PTSD), depression, interaction these conditions across 31 cohorts worldwide...