A5062330371- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Spine and Intervertebral Disc Pathology
- Intracranial Aneurysms: Treatment and Complications
- Spinal Fractures and Fixation Techniques
- Mesenchymal stem cell research
- Head and Neck Surgical Oncology
- Anesthesia and Neurotoxicity Research
- Cerebrospinal fluid and hydrocephalus
- S100 Proteins and Annexins
- Mitochondrial Function and Pathology
- Traumatic Brain Injury Research
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Intracerebral and Subarachnoid Hemorrhage Research
- Extracellular vesicles in disease
- Barrier Structure and Function Studies
- Epilepsy research and treatment
- Climate Change and Health Impacts
- Scoliosis diagnosis and treatment
- Amyotrophic Lateral Sclerosis Research
- Homelessness and Social Issues
- Neurogenesis and neuroplasticity mechanisms
- Spinal Dysraphism and Malformations
University of South Florida
2022-2024
Creative Commons
2022-2023
Duke University
2021-2022
Royal Edinburgh Hospital
1995
Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates brain age, compared to chronological may clarify the effects PTSD on and inform treatment approaches targeting neurobiology aging in context PTSD.Adult subjects (N = 2229; 56.2% male) aged 18-69 years (mean 35.6, SD 11.0) from 21 ENIGMA-PGC sites underwent T1-weighted structural magnetic resonance imaging, assessment (PTSD+, n 884). Previously trained voxel-wise (brainageR) region-of-interest...
The role of resting state functional MRI (rsfMRI) is increasing in the field epilepsy surgery because it possible to interpolate network connectivity patterns across brain with a high degree spatial resolution. Prior studies have shown that by rsfMRI scalp electroencephalography (EEG), an epileptogenic can be modeled and visualized characteristic are relevant both seizure-related neuropsychological outcomes after surgery. aim this study show 5-min acquisition time provides reproducible...
Transfer of healthy mitochondria from mesenchymal stem cells (MSCs) to ischemic neurons represents a potent stroke therapeutic. MSCs were grown under ambient conditions (nMSCs) or metabolic switching paradigm by alternating galactose and glucose in medium (sMSCs) then assayed for oxygen consumption rates using the Seahorse technology. Subsequently, primary subjected deprivation (OGD) co-cultured with either nMSCs sMSCs. Compared nMSCs, sMSCs displayed higher basal energy production, larger...
Strokes represent as one of the leading causes death and disability in USA, however, there is no optimal treatment to reduce occurrence or improve prognosis. Preconditioning tissues triggers ischemic tolerance, a physiological state that may involve metabolic switch (i.e. from glycolysis oxidative phosphorylation OxPhos) preserve tissue viability under an insult. Here, we hypothesized switching energy source glucose galactose cultured mesenchymal stem cells (MSCs) stands effective...
Hemorrhagic stroke (HS) is a disastrous occurrence with high mortality rates, however, there are no established treatments for this pathology. Given recent advances in stem cell therapies, concerted research efforts have elucidated the therapeutic potential of cells treating HS. In 2020, our group reviewed use SCs regulating neuroinflammatory reactions which occur after HS.1 This review will build on that work, highlighting more advancements field SC Ultimately, greater focus area research,...
Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly fatal neurological disease characterized by upper and lower motor neuron degeneration. Though typically idiopathic, familial forms of ALS are commonly composed superoxide dismutase 1 (SOD1) mutation. Basic science frequently utilizes SOD1 models in vitro vivo to replicate conditions. Therapies sparse; those that exist the market extend life minimally, thus driving demand for research identify novel therapeutics. Transplantation stem...
INTRODUCTION: The lateral transpsoas approach has become a valuable minimally invasive option in lumbar spine surgery to achieve fusion, decompression, and deformity correction. However, femoral nerve injury during psoas retraction remains significant concern, especially the lower spinal levels. A newer alternative electromyography (EMG), muscle mechanomyography (MMG) measures fiber oscillation contraction, providing more specific quantifiable response with high signal noise ratio. These...