A5079671011- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Fetal and Pediatric Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Craniofacial Disorders and Treatments
- Neonatal and fetal brain pathology
- Parkinson's Disease Mechanisms and Treatments
- Meningioma and schwannoma management
- Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Nerve injury and regeneration
- Cleft Lip and Palate Research
- Spinal Dysraphism and Malformations
- Transcranial Magnetic Stimulation Studies
- Mesenchymal stem cell research
- Intracranial Aneurysms: Treatment and Complications
University of South Florida
2016-2025
Neurological Surgery
2019-2024
Johns Hopkins University
2024
Johns Hopkins All Children's Hospital
2024
Tampa General Hospital
2020
Oxford University Press (United Kingdom)
2020
Laser interstitial thermal therapy (LITT) for mesial temporal lobe epilepsy (mTLE) has reported seizure freedom rates between 36% and 78% with at least 1 year of follow-up. Unfortunately, the lack robust methods capable incorporating inherent variability patient anatomy, ablated volumes, clinical outcomes have limited three-dimensional quantitative analysis surgical targeting its impact on outcomes. We therefore aimed to leverage a novel image-based methodology normalizing therapies across...
Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive alternative to surgical resection for drug-resistant mesial temporal lobe epilepsy (mTLE). Reported rates of seizure freedom are variable and long-term durability largely unproven. Anterior lobectomy (ATL) remains an option patients with MRgLITT treatment failure. However, the safety efficacy this staged strategy unknown.
Regulatory T-cells (T regs ) may exert a neuroprotective effect on ischemic stroke by inhibiting both inflammation and effector T-cell activation. Transplantation of human bone marrow-derived stem cells (BMSCs) in affords neuroprotection that results part from the cells’ anti-inflammatory property. However, relationship between T BMSCs treatment has not been fully elucidated. Here, we tested hypothesis within represent active mediators immunomodulation experimental stroke. Primary rat...
Postoperative neuropsychological deficits pose a significant challenge for temporal lobe epilepsy (TLE) surgery, particularly in the language-dominant hemisphere. Two surgical approaches have been suggested to mitigate such adverse outcomes: stereotactic laser amygdalohippocampectomy (SLAH) and hippocampus-sparing anterior lobectomy (HSATL). This retrospective cohort study compares seizure control outcomes of HSATL SLAH TLE. A compared 27 patients (nine male, mean age = 35.8 years) with...
Stroke-induced hypoxia causes oligodendrocyte death due to inflammation, lack of oxygen and exacerbation cell death. Bone marrow-derived stem cells (BMSCs) possess an endogenous population T-regulatory (Tregs) which reduce secretion pro-inflammatory cytokines that lead secondary Here, we hypothesize progenitor (OPCs) cultured with BMSCs containing their native Treg show greater viability, less cytokine myelin production after exposure oxygen-glucose deprivation reoxygenation (OGD/R) than...
The role of resting state functional MRI (rsfMRI) is increasing in the field epilepsy surgery because it possible to interpolate network connectivity patterns across brain with a high degree spatial resolution. Prior studies have shown that by rsfMRI scalp electroencephalography (EEG), an epileptogenic can be modeled and visualized characteristic are relevant both seizure-related neuropsychological outcomes after surgery. aim this study show 5-min acquisition time provides reproducible...
IntroductionSurgery remains an essential option for the treatment of medically intractable temporal lobe epilepsy (TLE). However, only 66% patients achieve postoperative seizure freedom, perhaps attributable to incomplete understanding brain network alterations in surgical candidates. Here, we applied a novel modeling algorithm and measured key characteristics epileptic networks correlated with outcomes objective measures cognition.MethodsTwenty-two were prospectively included, relevant...
The authors assessed the safety and accuracy of stereoelectroencephalography (SEEG) electrode implantation in pediatric patients who had previously undergone craniotomy compared to those without prior cranial surgery.
Laser interstitial thermal therapy (LITT) has recently gained popularity as a minimally invasive surgical option for the treatment of mesiotemporal epilepsy (mTLE). Similar to traditional open procedures epilepsy, most frequent neurological complications LITT are visual deficits; however, critical analysis these injuries is lacking.To evaluate deficits that occur after mTLE and their etiology.We surveyed five academic centers regularly perform cases self-reported postoperative deficits. For...
Background: Brain regions positively correlated with the epileptogenic zone in patients temporal lobe epilepsy vary spread across brain and degree of correlation to lobes, thalamus, limbic structures, these parameters have been associated pre-operative cognitive impairment seizure freedom after surgery, but negatively not as well studied. We hypothesize that connectivity within a network may predict which will respond best surgery. Methods: Scalp EEG resting state functional MRI (rsfMRI)...
Background Zygomatic osteotomy, an adjunct to middle cranial fossa (MCF) surgical approaches, improves the superior-inferior angle of approach and minimizes temporal lobe retraction. However, a decision-making algorithm for selective use zygomatic osteotomy impact on complications have not been well documented. Objective We described deciding whether in MCF surgery evaluated associated with osteotomy. Methods A retrospective review cases over 11 years at our academic tertiary referral center...
INTRODUCTION: Surgery remains an essential option for the treatment of medically intractable temporal lobe epilepsy. However, only 66% patients achieve postoperative seizure freedom, perhaps attributable to incomplete understanding brain network alterations in surgical candidates. Here, we present a novel modeling algorithm that may be used identify key characteristics epileptic networks correlated with improved outcome. METHODS: Twenty-nine were prospectively included, and relevant...
Giant aneurysms are infrequently complicated with obstructive hydrocephalus (HC), however, when concurrent, effective treatments unestablished. There incredibly few reports of HC due to basilar artery giant and fewer regarding ventriculoperitoneal (VP) shunt complications in these patients. We report the case a gentleman his 70 s who presented fusiform aneurysm entire mild intra-aneurysmal thrombosis. HC, secondary aneurysm, indicated VP placement. Within 12 h following placement, patient...
Background The zygomatic osteotomy, an adjunct to middle cranial fossa (MCF) surgical approaches, improves the superior–inferior angle of approach and minimizes temporal lobe retraction. However, impact osteotomy on approach-related complications has not been well documented. In this study, we evaluated associated with a as analyzed factors predictive for approaches.
Abstract In patients undergoing surgery for intractable temporal lobe epilepsy, the relationship between default mode network and patients’ neurocognitive outcome remains unclear. The objective of this study is to employ non-invasive mapping identify subdivisions function before after epilepsy in with epilepsy. Twenty-seven medically refractory were prospectively enrolled received resting state functional MRI neuropsychological testing both pre- post-operatively. Connectivity within was...
Di, Long BS, BA; Neal, Elliot G; Park, You J; Finch, David A; Maciver, Stephanie; Vale, Fernando L MD Author Information