A5075067196- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Photoreceptor and optogenetics research
- Botulinum Toxin and Related Neurological Disorders
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Spinal Cord Injury Research
- Laser Applications in Dentistry and Medicine
- Neural dynamics and brain function
- Pain Management and Treatment
- Autism Spectrum Disorder Research
- Muscle activation and electromyography studies
- Advanced MRI Techniques and Applications
- Trigeminal Neuralgia and Treatments
- Cerebrospinal fluid and hydrocephalus
- Nerve Injury and Rehabilitation
- Neurosurgical Procedures and Complications
- Spinal Dysraphism and Malformations
- Vagus Nerve Stimulation Research
West Virginia University
2020-2025
Vanderbilt University Medical Center
2014-2024
Blanchette Rockefeller Neurosciences Institute
2020-2024
Neuroscience Institute
2024
Vanderbilt University
2013-2023
Medical University of Vienna
2022-2023
Neurological Surgery
2008-2023
West Virginia University Hospitals
2023
University of Alberta
2018-2022
Neurosciences Institute
2022
Laser interstitial thermal therapy (LITT) for mesial temporal lobe epilepsy (mTLE) has reported seizure freedom rates between 36% and 78% with at least 1 year of follow-up. Unfortunately, the lack robust methods capable incorporating inherent variability patient anatomy, ablated volumes, clinical outcomes have limited three-dimensional quantitative analysis surgical targeting its impact on outcomes. We therefore aimed to leverage a novel image-based methodology normalizing therapies across...
For more than a century, the traditional method of stimulating neural activity has been based on electrical methods, and it remains gold standard to date. We report technological breakthrough in activation which low-level, pulsed infrared laser light is used elicit compound nerve muscle potentials mammalian peripheral vivo. Optically induced action are spatially precise, artifact free, damage free generated by use energies well below tissue ablation threshold. Thus optical stimulation...
A novel method for damage-free, artifact-free stimulation of neural tissue using pulsed, low-energy infrared laser light is presented. Optical elicits compound nerve and muscle potentials similar to responses obtained with conventional electrical in a rat sciatic model. Stimulation damage thresholds were determined as function wavelength tunable free electron source (=2 10 µm) solid state holmium:YAG (=2.12 µm). Threshold radiant exposure required varies from 0.312 J/cm2 (=3 1.22 (=2.1...
To report 5-year outcomes from the subthalamic nucleus (STN) deep brain stimulation (DBS) in early-stage Parkinson disease (PD) pilot clinical trial.
MRI-guided low-intensity focused ultrasound (FUS) has been shown to reversibly open the blood-brain barrier (BBB), with potential deliver therapeutic agents noninvasively target brain regions in patients Alzheimer's disease (AD) and other neurodegenerative conditions. Previously, authors reported short-term safety feasibility of FUS BBB opening hippocampus entorhinal cortex (EC) AD. Given need treat larger beyond EC, volumes locations treated have now expanded. To evaluate any adverse...
Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive alternative to surgical resection for drug-resistant mesial temporal lobe epilepsy (mTLE). Reported rates of seizure freedom are variable and long-term durability largely unproven. Anterior lobectomy (ATL) remains an option patients with MRgLITT treatment failure. However, the safety efficacy this staged strategy unknown.
Abstract Background and Objective Transient optical nerve stimulation is a promising new non‐contact, spatially precise, artifact‐free neural excitation technique useful in research clinical settings. This study evaluates safety of this pulsed infrared laser by histopathologic examination stimulated peripheral nerves. Study Design/Materials Methods Exposed rat sciatic nerves were functionally with the Holmium:YAG laser, previously validated as an effective tool for stimulation. Nerves...
Parkinson's disease is a neurodegenerative disorder characterized by progressive loss of dopaminergic cells in the central nervous system, particular substantia nigra, resulting an unrelenting motor and nonmotor function. Animal models reveal hyperactive neurons subthalamic nucleus that have increased firing rates bursting activity compared with controls. Although has been patients advanced-stage disease, it not described early-stage disease. Here we present results neuronal recordings from...
<h3>Objective</h3> Seizures in temporal lobe epilepsy (TLE) disturb brain networks and lead to connectivity disturbances. We previously hypothesised that recurrent seizures TLE may abnormal connections involving subcortical activating structures including the ascending reticular system (ARAS), contributing neocortical dysfunction neurocognitive impairments. However, no studies of ARAS have been reported patients with epilepsy. <h3>Methods</h3> used resting-state functional MRI recordings 27...
Objective Refractory psychiatric disease is a major cause of morbidity and mortality worldwide, there great need for new treatments. In the last decade, investigators piloted novel deep brain stimulation (DBS)-based therapies depression obsessive–compulsive disorder (OCD). Results from recent pivotal trials these therapies, however, did not demonstrate degree efficacy expected previous smaller trials. To discuss next steps, neurosurgeons, neurologists, psychiatrists representatives industry...
<h3>Objective</h3> To evaluate whether the progression of individual motor features was influenced by early deep brain stimulation (DBS), a post hoc analysis Unified Parkinson9s Disease Rating Scale–III (UPDRS-III) score (after 7-day washout) conducted from 2-year DBS in Parkinson disease (PD) pilot trial dataset. <h3>Methods</h3> The prospective enrolled patients with PD aged 50–75 years, treated medications for 6 months–4 and no history dyskinesia or other fluctuations, who were randomized...
In current practice, optimal placement of deep-brain stimulators (DBSs) used to treat movement disorders in patients with Parkinson's disease and essential tremor is an iterative procedure. A target chosen preoperatively based on anatomical landmarks identified magnetic resonance images. This point as initial position that refined intraoperatively using both microelectrode recordings macrostimulation. this paper, we report our progress toward developing a system for the computer-assisted...
<i>Background:</i> The microTargeting™ platform (MTP) stereotaxy system (FHC Inc., Bowdoin, Me., USA) was FDA approved in 2001 utilizing rapid-prototyping technology to create custom platforms for human procedures. It has also been called the STarFix (surgical targeting fixture) since it is based on concept of a patient- and procedure-specific surgical fixture. This an alternative stereotactic method by which planned trajectories are incorporated into custom-built, miniature...
The authors present a case in which high-frequency electrical stimulation of the cingulum using standard deep brain (DBS) technology resulted pain relief similar to that achieved with cingulotomy and superior periventricular gray matter (PVG) stimulation. This patient had complete spinal cord injury at C-4 level suffered from medically refractory neuropathic pain. He underwent placement bilateral unilateral PVG DBS electrodes 1-week blinded trial prior permanent implantation pulse generator....
While epilepsy studies rarely examine brainstem, we sought to the hypothesis that temporal lobe (TLE) leads subcortical arousal center dysfunction, contributing neocortical connectivity and neurocognitive disturbances.In this case-control study of 26 adult patients with TLE controls, used MRI measure structural functional cuneiform/subcuneiform nuclei (CSC), pedunculopontine nucleus, ventral tegmental area. Ascending reticular activating system patterns were related neuropsychological...
Infrared neural stimulation (INS) is a neurostimulation modality that uses pulsed infrared light to evoke artifact-free, spatially precise activity with noncontact interface; however, the technique has not been demonstrated in humans. The objective of this study demonstrate safety and efficacy INS humans vivo. feasibility was assessed patients (n=7) undergoing selective dorsal root rhizotomy, where hyperactive roots, identified for transection, were stimulated vivo on two three sites per...