A5077348743- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Memory Processes and Influences
- Transcranial Magnetic Stimulation Studies
- Cancer-related cognitive impairment studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurobiology of Language and Bilingualism
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Ultrasound and Hyperthermia Applications
- Neural and Behavioral Psychology Studies
- Glioma Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Cerebrospinal fluid and hydrocephalus
- Geriatric Care and Nursing Homes
- Brain Metastases and Treatment
- Pain Mechanisms and Treatments
- Cognitive Functions and Memory
- Muscle activation and electromyography studies
- Vagus Nerve Stimulation Research
- Substance Abuse Treatment and Outcomes
West Virginia University
2015-2024
Blanchette Rockefeller Neurosciences Institute
2019-2024
Morgantown High School
1997-2024
Vanderbilt University
2024
Center for Psychiatry and Behavioral Medicine
2022-2023
Neurology, Inc
2022-2023
University Radiology
2023
Institute on Aging
2013
National Institute on Aging
2013
Accident Compensation Corporation
2013
The blood–brain barrier (BBB) presents a significant challenge for treating brain disorders. hippocampus is key target novel therapeutics, playing an important role in Alzheimer’s disease (AD), epilepsy, and depression. Preclinical studies have shown that magnetic resonance (MR)-guided low-intensity focused ultrasound (FUS) can reversibly open the BBB facilitate delivery of targeted therapeutics. We report initial clinical trial results evaluating safety, feasibility, reversibility opening...
Antiamyloid antibodies have been used to reduce cerebral amyloid-beta (Aβ) load in patients with Alzheimer's disease. We applied focused ultrasound each of six monthly aducanumab infusions temporarily open the blood-brain barrier goal enhancing amyloid removal selected brain regions three participants over a period 6 months. The reduction level Aβ was numerically greater treated than homologous contralateral hemisphere that were not ultrasound, as measured by fluorine-18 florbetaben...
The primary aim of this pilot investigation was to identify structural brain differences in older adults with chronic low back pain (CLBP) as compared pain-free individuals.Cross-sectional, case-control.Sixteen cognitively intact adults, eight CLBP and pain-free; excluded if psychiatric or neurological disorders, substance abuse, opioid use, diabetes mellitus, and/or hypertension.Brain magnetic resonance imaging (MRI) tests neuropsychological performance (digit span, digit symbol...
Background Opening of the blood-brain barrier (BBB) induced with MRI-guided focused ultrasound has been shown in experimental animal models to reduce amyloid-β plaque burden, improve memory performance, and facilitate delivery therapeutic agents brain. However, physiologic effects this procedure humans Alzheimer disease (AD) require further investigation. Purpose To assess imaging ultrasound–induced BBB opening hippocampus human participants early AD evaluate fluid flow patterns after by...
The blood-brain barrier (BBB) limits therapeutic delivery in Alzheimer's disease (AD) and other neurological disorders. Animal models have demonstrated safe BBB opening reduction β-amyloid plaque with focused ultrasound (FUS). We recently the feasibility, safety, reversibility of FUS induced hippocampus entorhinal cortex 6 participants early AD. now report effect treatment on plaque. Six underwent 18F-Florbetaben PET scan at baseline one week after completion third (60 days interval)....
MRI-guided low-intensity focused ultrasound (FUS) has been shown to reversibly open the blood-brain barrier (BBB), with potential deliver therapeutic agents noninvasively target brain regions in patients Alzheimer's disease (AD) and other neurodegenerative conditions. Previously, authors reported short-term safety feasibility of FUS BBB opening hippocampus entorhinal cortex (EC) AD. Given need treat larger beyond EC, volumes locations treated have now expanded. To evaluate any adverse...
While current treatments for substance use disorder (SUD) are beneficial, success rates remain low and treatment outcomes complicated by co-occurring SUDs, many of which without available medication treatments. Research involving neuromodulation SUD has recently gained momentum. This study evaluated two doses (60 90 W) Low Intensity Focused Ultrasound (LIFU), targeting the bilateral nucleus accumbens (NAc), in individuals with SUD.Four participants (three male), who were receiving...
Abstract Background Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening is under investigation as a therapeutic modality for neurodegeneration, yet its effects in humans are incompletely understood. Here, we assessed physiologic responses to FUS administered multifocal brain sites of persons with Alzheimer’s disease (AD). Methods At tertiary neuroscience institute, eight participants AD (mean age 65, 38% F) enrolled phase 2 clinical trial underwent three successive targeted...
<b>BACKGROUND AND PURPOSE:</b> To our knowledge, no published studies have examined whole-brain regional differences to identify more discrete volumetric changes in the brains of childhood leukemia survivors. We used voxel-based morphometry (VBM) examine gray and white matter a group long-term survivors acute lymphoblastic (ALL) compared with healthy controls. Differences volume were expected, given previous reports during treatment for ALL reduced brain volumes Follow-up analyses...
There were more than 107,000 drug overdose deaths in the US 2021, most ever recorded. Despite advances behavioral and pharmacological treatments, over 50% of those receiving treatment for opioid use disorder (OUD) experience recurrence (relapse). Given prevalence OUD other substance disorders (SUDs), high rate recurrence, number deaths, novel strategies are desperately needed. The objective this study was to evaluate safety feasibility deep brain stimulation (DBS) targeting nucleus accumbens...
Background and Purpose —The fornix connects various structures involved in memory. We report a patient with anterograde amnesia after an acute ischemic infarct the anterior fornix. Case Description —A 71-year-old female acute-onset had neuroimaging studies showing infarction of both columns body genu corpus callosum. Neuropsychological evaluation revealed without evidence callosal disconnection. The showed marked improvement her memory function on follow-up visit. Conclusions —Amnesia this...
The primary aim of this pilot study was to identify structural and functional brain differences in older adults with self-reported disabling chronic low back pain (CLBP) compared those who reported nondisabling CLBP.Cross-sectional.Sixteen cognitively intact adults, eight CLBP CLBP. Exclusions were psychiatric or neurological disorders, substance abuse, opioid use, diabetes mellitus.Participants underwent: MRI; neuropsychological assessment using the Repeatable Battery for Assessment...
Background: Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are typically associated with very different clinical neuroanatomical presentations; however, there is increasing recognition of similarities. Objective: To examine memory executive functions, as well cortical thickness, glucose metabolism in AD bvFTD signature brain regions. Methods: We compared differences a group biomarker-defined participants clinically diagnosed bvFTD. These groups were also...
Development of an integrated family assessment inventory based on the Double ABCX and Circumplex models functioning its clinical utility was evaluated with 121 primary caregivers from a cognitive disorders program. The proposed model predicted significant proportion variance associated caregiver stress strain. Several aspects caregiving arrangement also emerged as key features in predicting depression. These findings supported model's central premise that both dyadic (caregiver-patient)...
Journal Article The Establishment of Clinical Cutoffs in Measuring Caregiver Burden Dementia Get access Eric D. Rankin, PhD, PhD 2 Associate Professor 2Address correspondence to Dr. Department Behavioral Medicine and Psychiatry, West Virginia University School Medicine, Morgantown, WV 26506-9124. Search for other works by this author on: Oxford Academic PubMed Google Scholar Marc W. Haut, 3Departments Medicine/Psychiatry Neurology, Robert Keefover, MD, MD 4Departments Michael Franzen,...
Stroke often involves primary motor cortex (M1) and its corticospinal projections (CST). As hand function is critically dependent on these structures, recovery incomplete. The neuronal substrate supporting affected not well understood but likely reorganized M1 CST of the lesioned hemisphere (M1IL CSTIL). We hypothesized that in chronic stroke related to structural functional reorganization M1IL CSTIL. tested 18 patients with ischemic involving or CST. Their was compared age-matched healthy...
The role of primary motor cortex (M1) in the control hand movements is still unclear. Functional magnetic resonance imaging (fMRI) studies unimanual performance reported a relationship between level precision task and additional ipsilateral M1 (iM1) activation. In present study, we determined whether demand on accuracy movement influences magnitude inhibitory effect cortices (IHI). We used transcranial stimulation (TMS) to measure active IHI (aIHI) iM1 contralateral (cM1) premovement period...
Abstract Recent advances in neuroimaging have enabled researchers to establish relatively specific areas of the brain that are involved working memory. In this positron emission tomography study we examined pattern neural activation associated with performance on number-letter sequencing, a purported measure memory included new Wechsler scales for and intelligence. After controlling basic audition, verbalization, attention, were observed orbital frontal lobe, dorsolateral prefrontal cortex,...