A5064448589- Brain Metastases and Treatment
- Ultrasound and Hyperthermia Applications
- Glioma Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
- Barrier Structure and Function Studies
- Ultrasound and Cavitation Phenomena
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Quinazolinone synthesis and applications
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound Imaging and Elastography
- Electrocatalysts for Energy Conversion
- Metalloenzymes and iron-sulfur proteins
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Nanoparticle-Based Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Graphene and Nanomaterials Applications
- MRI in cancer diagnosis
- Synthesis and Catalytic Reactions
- Molecular Sensors and Ion Detection
- Histone Deacetylase Inhibitors Research
Blanchette Rockefeller Neurosciences Institute
2023-2025
West Virginia University
2019-2025
Vanderbilt University
2024
Antiamyloid antibodies have been used to reduce cerebral amyloid-beta (Aβ) load in patients with Alzheimer's disease. We applied focused ultrasound each of six monthly aducanumab infusions temporarily open the blood-brain barrier goal enhancing amyloid removal selected brain regions three participants over a period 6 months. The reduction level Aβ was numerically greater treated than homologous contralateral hemisphere that were not ultrasound, as measured by fluorine-18 florbetaben...
Approximately 20% of all cancer patients will develop brain metastases in their lifespan. The standard care for with multiple is whole-brain radiation therapy, which disrupts the blood-brain barrier. Previous studies have shown inflammatory mediators play a role radiation-mediated increase permeability. Our goal was to determine if differential permeability post-radiation occurs between immunocompetent and immunocompromised mice.We utilized commissioned preclinical irradiator irradiate...
Background/Objective: The blood-brain barrier (BBB) is selectively permeable, but it also poses significant challenges for treating CNS diseases. Low-intensity focused ultrasound (LiFUS), paired with microbubbles a promising, non-invasive technique transiently opening the BBB, allowing enhanced drug delivery to central nervous system (CNS). However, downstream physiological effects following BBB opening, particularly secondary responses, are not well understood. This study aimed characterize...
Breast cancer patients presenting with symptomatic brain metastases have poor prognosis, and current chemotherapeutic agents are largely ineffective. In this study, we evaluated the hypomethylating agent azacitidine (AZA) for its potential as a novel therapeutic in preclinical models of metastasis breast cancer. We used parental triple-negative MDA-MB-231 (231) cells their colonizing counterpart (231Br) to ascertain phenotypic differences response AZA. observed that 231Br higher metastatic...
Systemic drug delivery to the central nervous system is limited by presence of blood-brain barrier (BBB). Low intensity focused ultrasound (LiFUS) a non-invasive technique disrupt BBB, though there lack understanding relationship between LiFUS parameters, such as cavitation dose, time sonication, microbubble and course magnitude BBB disruption. Discrepancies in these data arise from experimentation with modified, clinically untranslatable transducers inconsistent parameters for sonication....
The blood-brain barrier is the selectively permeable vasculature of brain vital for maintaining homeostasis and neurological function. Low permeability beneficial in presence toxins pathogens blood. However, metastatic tumors, it a challenge drug delivery. Although blood-tumor slightly leaky, still not permissive enough to allow accumulation therapeutic concentrations metastases. Herein, we discuss differences between primary tumors vasculature, effects therapeutics on barrier,...
Patients with metastatic breast cancer have high and continually increasing rates of brain metastases. During the course disease, metastases can occur in up to 30% these patients. In most cases, are diagnosed after significant disease progression. The blood-tumor barrier increases difficulty treating metastasis by preventing accumulation chemotherapy within at therapeutically effective concentrations. Traditional therapies, such as surgical resection, radiotherapy, chemotherapy, poor...
Abstract Lung cancer is the most common primary tumor to metastasize brain. Although advances in lung therapy have increased rates of survival over past few decades, control and treatment brain metastasis remains an urgent clinical need. Herein, we examine temporal coordination α-CTLA-4 administration combination with whole-brain radiation a syngeneic preclinical model both C57Bl/6 athymic nude mice. Brain burden, survival, weight loss were monitored. Immunotherapy 24 h prior irradiation...
Abstract Approximately 50% of all brain metastasis cases originate from primary lung tumors. Whole-brain radiation therapy (WBRT) is a common treatment for patients with multiple metastases, but rarely survive longer than one year after diagnosis. Recent studies demonstrate improved outcomes combinatorial radiotherapy and immunotherapy, the optimal timing immunotherapy administration unclear. Eliciting robust immune response post-immunotherapy vital therapeutic efficacy. Our work shows that...
Abstract Background Brain metastasis is a devastating stage of cancer progression, occurring in ~30% metastatic breast patients. Two-year survival rates for these patients low, and most typically survive less than one year. Treatments women are limited by the blood-brain barrier, but include cytotoxic chemotherapy, surgical resection, radiation therapy (whole-brain radiotherapy or stereotactic radiosurgery). Radiotherapy considered to be capable inducing disruption barrier eliciting an...
Abstract Brain metastases are associated with shortened survival and poorer quality of life in breast cancer patients. Recently, the importance platelet-derived growth factor-B (PDGFB) its stromally localized cognate receptor, factor receptor-beta (PDGFRβ) promoting metastasis to brain was identified by our group. Historically, PDGFB-to-PDGFRβ signaling is known promote angiogenesis vessel maturation both normal physiology cancer, but mechanism(s) behind this tumor stromal interplay poorly...
Abstract Lung cancer is the most common to metastasize brain, with 50% of all brain metastases originating from lung primary tumors. Traditional therapy for includes surgical resection, radiation, and chemotherapy. Due presence blood-tumor barrier, penetration therapeutics significantly hindered. Even when used in combination, tumor recurrence regrowth after initial chemoradiotherapy remain a significant issue. To recapitulate recurrent disease, we aim characterize radio-resistant...
Abstract Background: Incidence of patients having brain metastasis breast cancer has increased due to enhanced treatment for peripheral disease. Breast is often fatal and occurs in 15-20% diagnosed with stage IV cancer. Traditional chemotherapy delivery the limited by blood-brain barrier (BBB) blood-tumor (BTB). Low intensity focused ultrasound (LIFU) a unique technique recently investigated non-invasively disrupt these barriers aid neuro-modulation. Herein, we demonstrate use clinical LIFU...
Abstract Lung cancer is the most prevalent malignancy to affect both men and women. Around 80% of all lung cancers are classified as non-small cell (NSCLC). This subtype also likely metastasize brain. Clinically, common treatment for NSCLC epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), due high occurrence EGFR mutations. However, cells quickly develop resistance TKIs. added difficulty delivering drugs across blood-tumor barrier in efficacious concentrations treat...