A5083358393- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Behavioral and Psychological Studies
- Stress Responses and Cortisol
- Nausea and vomiting management
- Gambling Behavior and Treatments
- Sexuality, Behavior, and Technology
- Pituitary Gland Disorders and Treatments
- Mental Health Research Topics
- Genetic Syndromes and Imprinting
- Neuroendocrine Tumor Research Advances
- Attention Deficit Hyperactivity Disorder
- Neurofibromatosis and Schwannoma Cases
- Thyroid Cancer Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Thyroid Disorders and Treatments
- Glioma Diagnosis and Treatment
- Action Observation and Synchronization
- Treatment of Major Depression
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
Alder Hey Children's Hospital
2019-2025
University of Liverpool
2019-2025
William Harvey Research Institute
2021-2025
Queen Mary University of London
2021-2025
Barts Health NHS Trust
2025
Royal London Hospital
2025
West Virginia University
2023
Alder Hey Children's NHS Foundation Trust
2018-2022
Royal Devon & Exeter NHS Foundation Trust
2011
Dalhousie University
2001-2002
Changes in the activity of dopamine-containing systems relation to preparatory and consummatory feeding responses were investigated. In Experiment 1 rats conditioned associate food delivery with presentation a conditional stimulus (CS+). When sacrificed after exposure CS+ alone on test trial, ratio dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC/DA ratio) was increased significantly nucleus accumbens. A similar trend homovanillic (HVA/DA also observed. Similar increases observed...
The involvement of dopaminergic systems in appetitive and ingestive feeding behaviors was investigated two experiments. Conditioned preparatory responses to a conditional stimulus (CS+) signaling delivery meal were attenuated rats by doses 0.4 0.6 mg/kg the dopamine receptor antagonist pimozide. In contrast, animals responded normal fashion following food. Similarly, separate study, 20-min free-feeding intake liquid diet that had been deprived food for 23 hr unaffected pimozide as high...
Approximately 20% of all cancer patients will develop brain metastases in their lifespan. The standard care for with multiple is whole-brain radiation therapy, which disrupts the blood-brain barrier. Previous studies have shown inflammatory mediators play a role radiation-mediated increase permeability. Our goal was to determine if differential permeability post-radiation occurs between immunocompetent and immunocompromised mice.We utilized commissioned preclinical irradiator irradiate...
Journal Article Understanding Paulo Freire: reflections on the origins, concepts, and possible pitfalls of his educational approach Get access James Blackburn Search for other works by this author on: Oxford Academic Google Scholar Community Development Journal, Volume 35, Issue 1, January 2000, Pages 3–15, https://doi.org/10.1093/cdj/35.1.3 Published: 01 2000
Stearate-modified graphite paste electrodes were implanted chronically into dopamine terminal regions in the nucleus accumbens or caudate of rat. Reverse dialysis was used to demonstrate a selective response these dopamine, but not 3,4-dihydroxyphenylacetic acid ascorbic acid. In separate behavioural experiment, significant increase chronoamperometric observed during presentation conditional stimulus predictive food, and electrochemical remained elevated following consumption meal. Similar...
The main features of immunoglobulin superfamily, member 1 (IGSF1) deficiency are central hypothyroidism and macroorchidism. phenotype can be variable may include macrosomia, hypoprolactinemia, growth hormone (GH) secretory abnormalities, delayed puberty, obesity. We describe a novel de novo nonsense pathogenic variant c.3343C > T, p.(Gln1115*) that localizes to the 12th last immunoglobulin-like loop in C-terminal domain protein. patient was born breech with birth weight 3.7 kg. At...
Abstract Germline mutations in BRAF and other components of the MAPK pathway are associated with congenital syndromes collectively known as RASopathies. Here, we report association Septo-Optic Dysplasia (SOD) including hypopituitarism Cardio-Facio-Cutaneous (CFC) syndrome patients harbouring . Phosphoproteomic analyses demonstrate that these genetic variants gain-of-function leading to activation pathway. Activation by conditional expression Braf V600E/ + allele, or knock-in Q241R/+ allele...
The effects of metoclopramide and thioridazine on feeding behaviors male hooded rats were investigated in 2 experiments. Metoclopramide (2.5-7.5 mg/kg) attenuated conditioned preparatory responses to a conditional stimulus signaling delivery meal. However, consummatory affected only by the highest dose. Similar had previously been observed following administration pimozide (Blackburn, Phillips, & Fibiger, 1987). Thioridazine (10-30 no significant effect any measure behavior. different drugs...
The authors examined heart rate responses to video lottery terminal (VLT) play and alcohol intake. Forty-four VLT players were randomized an (mean blood concentration=0.06%) or a control beverage condition. Heart was recorded at pre- postdrinking baseline during play. Alcohol participants displayed elevated rates relative controls Controls both baselines, whereas elevations post- predrinking postdrinking. increases from greater among controls. Results provide novel information that the...