A5000948551- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- RNA regulation and disease
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Sirtuins and Resveratrol in Medicine
- Neurogenesis and neuroplasticity mechanisms
- Endoplasmic Reticulum Stress and Disease
- Growth Hormone and Insulin-like Growth Factors
- MicroRNA in disease regulation
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Advanced Glycation End Products research
- Inflammatory mediators and NSAID effects
- Circadian rhythm and melatonin
- Advanced MRI Techniques and Applications
- Inflammasome and immune disorders
- Neurological Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiovascular Health and Risk Factors
- Gut microbiota and health
- Lung Cancer Research Studies
Guangdong Academy of Medical Sciences
2017-2025
Southern Medical University
2023-2025
Guangdong Provincial People's Hospital
2023-2025
China-Japan Friendship Hospital
2021-2025
Wuhan City Chinese Medicine Hospital
2025
Jinzhou Medical University
2015-2024
Guangxi University
2022-2024
Key Laboratory of Guangdong Province
2023
Ocean University of China
2018-2023
Qingdao National Laboratory for Marine Science and Technology
2023
The blood-brain barrier (BBB) limits therapeutic delivery in Alzheimer's disease (AD) and other neurological disorders. Animal models have demonstrated safe BBB opening reduction β-amyloid plaque with focused ultrasound (FUS). We recently the feasibility, safety, reversibility of FUS induced hippocampus entorhinal cortex 6 participants early AD. now report effect treatment on plaque. Six underwent 18F-Florbetaben PET scan at baseline one week after completion third (60 days interval)....
Abstract Background Ischemic stroke is a serious cerebrovascular disease with high morbidity and disability. Zinc accumulation has been shown to play vital role in neuronal death blood–brain barrier damage following ischemia acute stage. However, almost nothing known about whether zinc involved neurological recovery ischemic prolonged period. This study investigates promotes through astrocytes‐induced angiogenesis during repair phase. Methods Sprague–Dawley rats were subjected 2 h...
Micro-RNAs (miRs) have emerged as key gene regulators in many diseases, including stroke. We recently reported that miR-30a protects N2A cells against ischemic injury, part through enhancing beclin 1-mediated autophagy. The present study explores further the involvement of ischemia-induced apoptosis and its possible mechanisms primary cortical neurons stroked mouse brain. demonstrate level is significantly decreased after 1-hr oxygen-glucose deprivation (OGD)/24-hr reoxygenation....
While pre-conditioning is induced before stroke onset, ischemic post-conditioning (IPostC) performed after reperfusion, which typically refers to a series of mechanical interruption blood reperfusion stroke. IPostC known reduce infarction in wild-type animals. We investigated if protects against brain injury by focal ischemia Tcell-deficient nude rats and examine its effects on Akt the mammalian target rapamycin (mTOR) pathway. Although reduced infarct size at 2 days post-stroke rats, it did...
Abstract Background Ischemic stroke leads a primary cause of mortality in human diseases, with high disability rate worldwide. This study aims to investigate the function β‐1,4‐galactosyltransferase 1 (B4galt1) mouse brain ischemia/reperfusion (I/R) injury. Methods Recombinant B4galt1 (rh‐B4galt1) was intranasally administered mice model middle cerebral artery occlusion (MCAO)/reperfusion. In this study, impact rh‐B4galt1 on injury assessed using multiple methods, including neurological...
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment. Objective To elucidate the potential mechanisms of Sheng-Hui-Yi-Zhi (SHYZ) for treatment AD and explore effective substances SHYZ. Methods Liquid chromatography-mass spectrometry (LC-MS) was used to identify active components Network pharmacology employed predict targets pathways SHYZ in AD. SAMP8 mice were as model treated with The Morris water maze utilized assess learning...
<title>Abstract</title> Background Osteoarthritis (OA) is a common degenerative joint disorder marked by the deterioration of cartilage, discomfort, and inflammation. The Bushenhuoluo Decoction (BSHLD) traditional Chinese remedy utilized for management OA. aim this study to examine elucidate mechanism BSHLD how compound interacts with target Methods We used network pharmacology approach that integrates multiple bioinformatics techniques First, we collected analyzed OA datasets from Gene...
To explore the feasibility of reducing scan duration 13N-NH3 myocardial perfusion imaging (MPI) using a total-body PET/CT scanner. Forty-five patients with known or suspected coronary artery disease (CAD) performing rest MPI were retrospectively included. PET data acquired in list mode for 10 min, and reconstructed into sequence images different duration: 10-min, 7-min, 5-min, 3-min, 2-min (G10 to G2). Subjective visual evaluation including overall impression, image noise lesion visibility...
In most animals, steroid hormones are crucial regulators of physiology and developmental life transitions. Steroid synthesis depends on extrinsic parameters autoregulatory processes to fine-tune the dynamics hormone production. Drosophila, transient increases prohormone ecdysone, produced at each larval stage, necessary trigger moulting metamorphosis. Binding active ecdysone (20-hydroxyecdysone) its receptor (EcR) is followed by sequential expression nuclear receptors E75, DHR3 βFtz-f1,...
Significance The pathophysiology of depression remains unclear, but accumulated evidence implicates disturbances in monoaminergic transmission the brain. Several studies suggest that members diverse family neuropeptides may also be involved. In rat, neuropeptide galanin is coexpressed with noradrenaline and serotonin, modulates signaling these neurotransmitters. Here, we explored a possible role its receptors rat model based on chronic mild stress using quantitative real-time PCR combined...
Past studies suggested that during early lactation and the transition period, higher plasma growth hormone (GH) levels in subclinical ketosis (SCK) might involve initiation of body adipose tissues mobilization, resulting metabolic disorders ruminants particularly hyperketonemia. The upregulated GH mRNA expression tissue may take part adipolysis process SCK-affected cows paves a way for study further. This aimed to characterize GH, β-hydroxybutyrate acid (BHBA) non-esterified fatty (NEFA)...
Type 2 diabetes (T2D) is a chronic metabolic disorder characterized by hyperglycemia and dyslipidemia. The termite fungus comb an integral component of nests termites, which are global pest. Termite polysaccharides (TFCPs) have been identified to possess antioxidant, anti-aging, immune-enhancing properties. However, their physicochemical characteristics role in fighting not previously reported. In the current study, TFCPs were isolated structurally characterized. yield was determined be...
Thyrostimulin, consisting of GpA2 and GpB5 subunits, has been identified in amphioxus, but to date, little is known about the roles GPA2/GPB5‒type hormone this evolutionarily important animal. We showed here that amphioxus GpA2, GpB5, TSH receptor (TSHR) represent archetypes vertebrate TSHα, TSHβ, TSHR, respectively, both gpa2 gpb5 were coexpressed Hatschek pit, a homolog pituitary, amphioxus. also recombinant like zebrafish TSHα bound TSHR tethered thyrostimulin activated protein kinase A C...
Ischemic stroke is one of the major causes morbidity and mortality. The β-1, 3-galactosyltransferase 2 (B3galt2), a member family, playing vital role in pathological process cerebral ischemic injury, but its underlying mechanisms remain unclear. In present study, we examined involvement oxidative stress NLRP3 inflammasome activation neuroprotective effect B3galt2. Cerebral ischemia/reperfusion (I/R) injury was simulated mouse middle artery occlusion (MCAO) model. Recombinant human B3galt2...
The aims of this study were to delineate the expression fatty-acid binding protein (FABP) 4 in human uterine endometrium and its function regulation proliferation, migration invasion epithelial cells. Immunohistochenistry, immunofluorence Western blotting used determine cellular localization FABP4 endometrial cell lines. Interference small ribonuclear acid (siRNA) specific inhibitor inhibit FABP4. cells evaluated with CCK-8 assay, wound-healing test transwell analysis respectively. We found...
Purpose To investigate the role of CXCR4-targeted 68 Ga-pentixafor PET/CT imaging in inflammatory bowel disease (IBD). Methods Five IBD patients and 12 control subjects performing examinations were included. endoscopic findings recorded compared. The semiquantitative parameters uptake by lesion segments normal intestines investigated. Results Among these 5 patients, endoscopy successfully examined a total 26 intestinal segments, with 13 showing lesions. was positive all endoscopy-proven...