A5031388779- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism, Diabetes, and Cancer
- Cancer Mechanisms and Therapy
- Assisted Reproductive Technology and Twin Pregnancy
- Pancreatic function and diabetes
- Protease and Inhibitor Mechanisms
- Reproductive Biology and Fertility
- Diabetes Treatment and Management
- Gastrointestinal motility and disorders
- Cancer, Hypoxia, and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- RNA modifications and cancer
- MicroRNA in disease regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Plant-based Medicinal Research
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Alzheimer's disease research and treatments
- Ovarian function and disorders
- Atherosclerosis and Cardiovascular Diseases
- Colorectal and Anal Carcinomas
- Peptidase Inhibition and Analysis
- Dermatology and Skin Diseases
- Radio, Podcasts, and Digital Media
Nanchang University
2019-2025
China-Japan Friendship Hospital
2012-2025
Hubei University of Medicine
2012-2024
University of California, San Francisco
2012-2024
University of Hawaii Cancer Center
2024
Cancer Center of Hawaii
2024
University of Hawaii System
2024
Dalian Medical University
2024
University of Hawaiʻi at Mānoa
2024
Dongfeng General Hospital
2008-2023
Protease-activated receptor (PAR)-1 is a cellular for thrombin that activated after proteolytic cleavage. The contribution of PAR-1 to inflammatory cell–mediated renal injury was assessed in murine crescentic glomerulonephritis (GN). A pivotal role this model demonstrated by the capacity hirudin, selective antagonist, attenuate injury. Compared with control treatment, hirudin significantly reduced glomerular crescent formation, T cell and macrophage infiltration, fibrin deposition, elevated...
•A novel mouse model of intrahepatic cholangiocarcinoma (ICC) was established.•Hydrodynamic transfection activated forms AKT and Yap used to induce ICC.•This recapitulates many morphological molecular features human ICC.•MLN0128 may be superior gemcitabine/oxaliplatin based chemotherapy treat ICC.•The efficacy MLN0128 is mainly attributed induction apoptosis ICC cells. Background & AimsIntrahepatic a lethal malignancy without effective treatment options. MLN0128, second generation pan-mTOR...
Increased colonic bile acid (BA) exposure, frequent in diarrhea-predominant irritable bowel syndrome (IBS-D), can affect gut function. Nerve growth factor (NGF) is implicated the development of visceral hyper-sensitivity (VH). In this study, we tested hypothesis that BAs cause VH via mucosal mast cell (MMC)-to-nociceptor signaling, which involves farnesoid X receptor (FXR)/NGF/transient potential vanilloid (TRPV)1 axis. were intracolonically administered to rats for 15 d. Visceral...
Liver enzymes are associated with liver function, but their relationship body mass index (BMI) remains unclear. This cross-sectional study aimed to identify correlations between serum enzyme levels and BMI in the general population. The data were derived from Dryad Digital Repository. Smooth curve multiple linear regression analyses performed evaluate associations levels. A total of 15,464 participants, including 8430 males (54.5%), included study, a median age 43.7 years. revealed that...
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment. Objective To elucidate the potential mechanisms of Sheng-Hui-Yi-Zhi (SHYZ) for treatment AD and explore effective substances SHYZ. Methods Liquid chromatography-mass spectrometry (LC-MS) was used to identify active components Network pharmacology employed predict targets pathways SHYZ in AD. SAMP8 mice were as model treated with The Morris water maze utilized assess learning...
To date, the lowest protective SGLT2 inhibitor dose is unknown. We initially performed a dose-response pilot study in normal rats. Based on results of this we compared cardio-renal effects SGLT-2 empagliflozin, with placebo or telmisartan rats 5/6 nephrectomy (5/6 Nx) high salt diet (HSD). The experimental set up was as follows: Sham operation (Sham) and placebo; Nx 2% HSD empagliflozin (0.6 mg/kg/day, bid); (5 qd). Empagliflozin treatment increased urinary glucose excretion, parallel to...
Abstract Pim‐3 is a member of proto‐oncogene Pim family that encodes serine/threonine kinases. proteins regulate both apoptosis and cellular metabolism by phosphorylating their substrates. Here, we report for the first time highly expressed at mRNA protein levels in endothelial cells (ECs). We found concentrated lamellipodia co‐localized with focal adhesion kinase (FAK). was dispersed from when ECs were treated cytochalasin D, an inhibitor actin polymerization. In addition, small‐interfering...
The urokinase receptor (uPAR) is a multifunctional molecule involved in pericellular, fibrinolytic, and proteolytic activities, as well cell adhesion chemotaxis may play role the pathogenesis of tissue remodeling occurring during glomerulonephritis. We analyzed sequentially expression uPAR by immunohistochemistry situ hybridization an accelerated model nephrotoxic nephritis rats. A strong induction mRNA was observed glomeruli soon 1 h after serum injection. intensity glomerular antigen...
Abstract Acute myocardial infarction (AMI) remains one of the leading causes morbidity and mortality worldwide. Ischemia/reperfusion (I/R), most common consequence AMI treatment, may induce severe cell injury, yet precise mechanism continues to be enigmatic. In present study, we found that miR‐129‐5p was significantly downregulated in mouse I/R model. Then, overexpressed via intravenous injection specific agomir before model establishment. MiR‐129‐5p overexpression dramatically alleviated...
Abstract Objective The present study investigated the potential correlation between non-high-density lipoprotein cholesterol/high-density cholesterol ratio (non-HDL-C/HDL) and formation of coronary collateral circulation (CCC) in artery disease cases with chronic total occlusive (CTO) lesions. Methods Two experienced cardiologists identified selected patients CTO lesions for retrospective analysis. 353 were divided into a CCC poor group (Rentrop 0–1 grade, n = 209) good 2–3 144) based on...
Endometrial cancer (EC) is a malignant tumor of the female reproductive tract.Due to its rapid growth and invasiveness, EC currently only gynecological neoplasm with rising incidence mortality rates.It great significance explore metabolomics signature stage I II for diagnosis treatment.A mass spectrometry-based untargeted approach was used preoperative serum metabolites in normal patients.The were mapped Ingenuity pathway analysis (IPA) database determine potential biomarkers metabolic...
This study aims to evaluate the efficacy and safety of endovascular therapy versus neurosurgical clipping carried out for patients with unruptured middle cerebral artery bifurcation aneurysms (MCABAs). Patients diagnosed MCABAs were enrolled in this prospective according inclusion exclusion standard. Enrolled divided into a group (endovascular therapy) control (neurosurgical clipping), 65 cases each group. In terms efficacy, we found that proportion Glasgow Outcome Scale (GOS) grade 1 after...
Objective. To evaluate the hematoma clearance and safety of small bone window craniotomy through lateral fissure Rolandic point-insular lobe approach for patients with hypertensive intracerebral hemorrhage (HICH) in posterior basal ganglia. Methods. This retrospective study enrolled a total 86 HICH ganglia region who underwent surgery between January 2020 December 2021. These were divided into two groups: conventional group group. The intraoperative information, postoperative rate,...
The artificial pancreas concept automates the delivery of insulin to patients with type-1 diabetes, sensing blood glucose levels through a continuous monitor (CGM) and using an infusion pump deliver insulin. Formally verifying control algorithms against physiological models patient is important challenge. In this paper, we present case study simple hybrid multi-basal system that switches different preset rates over various ranges levels. We use Dalla- Man model for modeling physiology...
Advanced glycation end-product is a modified form of low-density lipoprotein (AGE-LDL) and accelerates atherosclerosis through undefined mechanisms. Programmed cell death protein 4 (PDCD4), transcriptional regulator, plays an important role in the regulation autophagy. The aim present study was to investigate PDCD4 involved AGE-LDL-induced foam formation.The characterization AGE-LDL measured by thiobarbituric assay agarose gel electrophoresis vitro. RAW264.7, THP-1 line primary peritoneal...