A5103029651- Metal-Organic Frameworks: Synthesis and Applications
- Covalent Organic Framework Applications
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Nanoparticle-Based Drug Delivery
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Algal biology and biofuel production
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Luminescence and Fluorescent Materials
- Biosensors and Analytical Detection
- Biofuel production and bioconversion
- Microbial Metabolites in Food Biotechnology
- Pickering emulsions and particle stabilization
Peng Cheng Laboratory
2024-2025
Second Hospital of Shanxi Medical University
2021-2025
Shanxi Medical University
2021-2025
Zhejiang University
2014-2025
Shanghai Micro Satellite Engineering Center
2024
Harbin Medical University
2024
Chinese Institute for Brain Research
2024
Hebei Medical University
2020-2023
Second Hospital of Hebei Medical University
2020-2023
Shenzhen University Health Science Center
2022-2023
Abstract Self‐assembly of luminescent moieties into porous metal–organic frameworks (MOFs) has generated many platforms for probing volatile organic molecules (VOMs). However, most those explored thus far have only been based on the luminescence intensity one transition, which is not efficient different VOMs. We synthesized a MOF material containing 1D nanotube channels, and further developed dye@MOF platform to realize VOMs by tuning energy transfer efficiency between two emissions. The...
Liver cancer comprises a group of malignant tumors, among which hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common. ICC is especially pernicious associated with poor clinical outcome. Studies have shown that subset human ICCs may originate from mature hepatocytes. However, mechanisms driving trans-differentiation hepatocytes into cholangiocytes remain poorly defined. We adopted lineage tracing techniques an established murine hepatocyte-derived model...
•A novel mouse model of intrahepatic cholangiocarcinoma (ICC) was established.•Hydrodynamic transfection activated forms AKT and Yap used to induce ICC.•This recapitulates many morphological molecular features human ICC.•MLN0128 may be superior gemcitabine/oxaliplatin based chemotherapy treat ICC.•The efficacy MLN0128 is mainly attributed induction apoptosis ICC cells. Background & AimsIntrahepatic a lethal malignancy without effective treatment options. MLN0128, second generation pan-mTOR...
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide, and therapeutic agents for this malignancy are lacking. MicroRNAs play critical roles in carcinogenesis present tremendous potential. Here, we report that microRNA‐206 a robust tumor suppressor plays important development HCC by regulating cell‐cycle progression cMet signaling pathway. MicroRNA‐206 was underexpressed livers two mouse models, human individuals bearing HCC, cell lines. Combining bioinformatic...
Aggregation-induced emission (AIE)-active luminogens (AIEgens) have demonstrated exciting potential for the application in cancer phototheranostics. However, simultaneously achieving tumor-activated bright emission, enhanced reactive oxygen species (ROS) generation, high tumor accumulation, and minimized ROS depletion remains challenging. Here, a metal–organic framework (MOF) hybrid AIEgen theranostic platform is designed, termed A-NUiO@DCDA@ZIF-Cu, composed of an AIEgen-loaded hydrophobic...
Controllable self-assembly of the DNA-linked gold nanoparticle (AuNP) architecture for in vivo biomedical applications remains a key challenge. Here, we describe use programmed DNA tetrahedral structure to control assembly three different types AuNPs (∼20, 10, and 5 nm) by organizing them into defined positioning arrangement. A DNA-assembled "core-satellite" is built sequencing where satellite (10 surround central core AuNP (20 nm). The density arrangement satellites around were controlled...
Abstract Self‐assembly of luminescent moieties into porous metal–organic frameworks (MOFs) has generated many platforms for probing volatile organic molecules (VOMs). However, most those explored thus far have only been based on the luminescence intensity one transition, which is not efficient different VOMs. We synthesized a MOF material containing 1D nanotube channels, and further developed dye@MOF platform to realize VOMs by tuning energy transfer efficiency between two emissions. The...
Aggregation-induced emission (AIE) or aggregation-induced enhancement (AIEE) has endowed gold species with responsive fluorescent properties, favoring their potential applications in sensing, imaging, and therapy. However, it remains an interesting challenge to fabricate fluorophores both AIE AIEE effects. Herein, we presented highly luminescent Au(I) thiolate nanocomplex-based biosensors Zn2+ induced-AIE zeolite imidazolate framework (ZIF-8) induced-AIEE The nonemissive monovalent...
The principal hallmark of Alzheimer's disease (AD) is neuron mitochondrial dysfunction, whereas miRNAs potentially play important roles. Nevertheless, efficacious mitochondria organelle therapeutic agents for treatment and management AD are highly advisable. Herein, we report a multifunctional DNA tetrahedron-based mitochondria-targeted platform, termed tetrahedral framework-based nanoparticles (TDFNs), which was modified with triphenylphosphine (TPP) mitochondria-targeting, cholesterol...
An effective strategy to incorporate accessible metalloporphyrin photoactive sites into 2D COFs by establishing a 3D local connection for highly efficient photocatalysis was developed.
Abstract Background Ischemia-reperfusion injury of the spinal cord (SCII) often leads to unalterable neurological deficits, which may be associated with apoptosis induced by oxidative stress and inflammation. Astaxanthin (AST) is a strong antioxidant anti-inflammatory agent multitarget neuroprotective effects. This study aimed investigate potential therapeutic effects AST for SCII molecular mechanism. Methods Rat models abdominal aortic occlusion 40 min were carried out on recovery SCII....
Abstract Semihydrogenation of alkynes to produce alkenes is very important in the industry; however, over‐hydrogenation heavily complicates postprocesses, which are highly energy consuming and not environmentally friendly. One most efficient pathways solve this challenging issue develop selective catalysts that could only hydrogenate inactive hydrogenation alkenes. This work presents herein an catalyst, consisting situ created PdS 0.53 nanoparticles as redox‐active sites inside defect pores...
Epigenetic modifications such as DNA methylation are well known connected with many important biological processes. Rapid accumulating evidence shows environmental stress can generate particular defense epigenetic changes across generations in eukaryotes. This transgenerational inheritance animals and plants has gained interest over the last years. Cyanobacteria play very crucial role earth, primary producer they adapt to nearly all diverse environments. However, few knowledge about genome...
Submicrometer-sized magnetite colloid nanocrystal clusters (MCNCs) provide a new avenue for constructing uniformly sized and highly magnetic composite submicrospheres. Herein, facile eco-friendly method is described the synthesis of Fe3O4@poly(acrylic acid) (PAA)/chitosan (CS) core-shell submicrospheres using MCNCs bearing carboxyl groups as cores. It based on self-assembly positively charged CS chains surface oppositely dispersed in aqueous solution containing acrylic acid (AA) cross-linker...
Abstract Intrahepatic cholangiocarcinoma (iCCA) is a deadly malignancy with limited treatment options. Gain-of-function mutations in K-Ras very frequent alteration, occurring ~15 to 25% of human iCCA patients. Here, we established new model by expressing activated forms Notch1 (NICD) and (K-Ras V12D ) the mouse liver (K-Ras/NICD mice). Furthermore, investigated therapeutic potential MEK inhibitors vitro vivo using CCA cell lines K-Ras/NICD mice, respectively. Treatment U0126, PD901,...
Mitochondria-targeted therapeutics are an attractive approach against energy-dependent cancer. However, effective mitochondria organelle agents still highly desirable. Herein, a mitochondria-targeted platform, termed CDM@MUiO-DP@MCHM, consisting of macrophages-cancer hybrid membrane (MCHM) encapsulated MUiO-66 metal-organic frameworks (MOFs) is reported, which loaded with microRNA (miRNA) biomarker detection probe (DP) for cancer diagnosis and copper-depleting moiety (CDM) mitochondrial...
Accurate diagnosis of the periprosthetic joint infection (PJI) remains a challenge for surgeons. The purpose this study was to assess value albumin globulin ratio (AGR) and (GLB) diagnosing PJI.