A5062869403- Advancements in Battery Materials
- Phagocytosis and Immune Regulation
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Electron and X-Ray Spectroscopy Techniques
- Cancer Mechanisms and Therapy
- Advanced Battery Materials and Technologies
- Multiple Myeloma Research and Treatments
- Mass Spectrometry Techniques and Applications
- Growth Hormone and Insulin-like Growth Factors
- Semiconductor materials and interfaces
- Nanoplatforms for cancer theranostics
- Cell death mechanisms and regulation
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Semiconductor materials and devices
- Mast cells and histamine
- Supercapacitor Materials and Fabrication
- Melanoma and MAPK Pathways
- Immune Cell Function and Interaction
- Advanced Battery Technologies Research
- Virus-based gene therapy research
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Advanced Proteomics Techniques and Applications
Longgang Central Hospital
2025
University of Liverpool
2017-2024
The Faraday Institution
2022-2024
Wuhan University of Science and Technology
2020-2024
China Aerodynamics Research and Development Center
2024
Harbin Institute of Technology
2022-2023
PLA Information Engineering University
2023
Calithera (United States)
2015-2022
Northeastern University
2011-2021
Heilongjiang Provincial Academy of Agricultural Sciences
2015-2020
Abstract Accumulating evidence suggests important roles for the receptor tyrosine kinase Axl in cancer progression, invasion, metastasis, drug resistance, and patient mortality, highlighting as an attractive target therapeutic development. We have generated characterized a potent selective small-molecule inhibitor, R428, that blocks catalytic procancerous activities of Axl. R428 inhibits with low nanomolar activity blocked Axl-dependent events, including Akt phosphorylation, breast cell...
<h3>Background</h3> Myeloid cells are an abundant leukocyte in many types of tumors and contribute to immune evasion. Expression the enzyme arginase 1 (Arg1) is a defining feature immunosuppressive myeloid leads depletion L-arginine, nutrient required for T cell natural killer (NK) proliferation. Here we use CB-1158, potent orally-bioavailable small-molecule inhibitor arginase, investigate role Arg1 regulating anti-tumor immunity. <h3>Methods</h3> CB-1158 was tested ability block...
Wireless sensor networks (WSNs) are composed of a large number inexpensive power-constrained wireless nodes, which detect and monitor physical parameters around them through self-organization. Utilizing clustering algorithms to form hierarchical network topology is common method implementing management data aggregation in WSNs. Assuming that the residual energy nodes follows random distribution, we propose load-balanced algorithm for WSNs on basis their distance density making it essentially...
The chemical and electrochemical reactions at the positive electrode-electrolyte interface in Li-ion batteries are hugely influential on cycle life safety. Ni-rich layered transition metal oxides exhibit higher interfacial reactivity than their lower Ni-content analogues, reacting via mechanisms that poorly understood. Here, we study pivotal role of electrolyte solvent, specifically cyclic ethylene carbonate (EC) linear ethyl methyl (EMC), determining charged LiNi0.33Mn0.33Co0.33O2 (NMC111)...
High-capacity Ni-rich layered metal oxide cathodes are highly desirable to increase the energy density of lithium-ion batteries. However, these materials suffer from poor cycling performance, which is exacerbated by increased cell voltage. We demonstrate here detrimental effect ethylene carbonate (EC), a core component in conventional electrolytes, when NMC811 (LiNi0.8Mn0.1Co0.1O2) charged above 4.4 V vs Li/Li+-the onset potential for lattice oxygen release. Oxygen loss enhanced...
Shotgun tandem mass spectrometry-based peptide sequencing using programs such as SEQUEST allows high-throughput identification of peptides, which in turn the corresponding proteins. We have applied a machine learning algorithm, called support vector machine, to discriminate between correctly and incorrectly identified peptides output. Each was characterized by SEQUEST-calculated features delta Cn Xcorr, measurements precursor ion current mass, additional calculated parameters fraction...
AbstractThe insulin-like growth factor I (IGF-I) receptor (IGF-IR) is known to regulate a variety of cellular processes including cell proliferation, survival, differentiation, and transformation. IRS-1 Shc, substrates the IGF-IR, are mediate IGF-IR signaling pathways such as those mitogen-activated protein kinase (MAPK) phosphatidylinositol 3-kinase (PI3K), which believed play important roles in some IGF-IR-dependent biological functions. We used cytoplasmic domain yeast two-hybrid...
Stat3 is activated by phosphorylation on Tyr-705, which leads to dimer formation, nuclear translocation, and regulation of gene expression. Serine mitogen-activated protein kinase has also been observed in cells responding epidermal growth factor shown affect its tyrosine transcriptional activity. induced interleukin-6 (IL-6) stimulation, be independent sensitive the Ser/Thr inhibitor H7. In this study, we investigated whether C (PKC) that responsible for serine IL-6 stimulation isoform PKCs...
// Polina Matre 1, * , Juliana Velez Rodrigo Jacamo 1 Yuan Qi 2 Xiaoping Su Tianyu Cai Steven M. Chan 3 Alessia Lodi 4 Shannon R. Sweeney Helen Ma Richard Eric Davis 5 Natalia Baran Torsten Haferlach 6 Xiaohua 7 Elsa Renee Flores Doriann Gonzalez Sergej Konoplev 8 Ismael Samudio 9 Courtney DiNardo Ravi Majeti Aaron D. Schimmer 10 Weiqun Li 11 Taotao Wang Stefano Tiziani Marina Konopleva Departments of Leukemia, The University Texas MD Anderson Cancer Center, Houston, TX, USA Bioinformatics...
Songnen Plain is originally one of the three major glasslands in China and has now become most concentrated distribution areas sodic-saline soil worldwide. The continuously degraded by natural anthropogenic processes, which a negative impact on agricultural production. investigation microbial diversity this ecosystem fundamental for comprehending biological ecological processes harnessing potential resources. Illumina MiSeq sequencing method was practiced to investigate bacterial composition...
Abstract Demand for low carbon energy storage has highlighted the importance of imaging techniques characterization electrode microstructures to determine key parameters associated with battery manufacture, operation, degradation, and failure both next generation lithium other novel systems. Here, recent progress literature highlights from magnetic resonance, neutron, X‐ray, focused ion beam, scanning transmission electron microscopy are summarized. Two major trends identified: First, use...
At various stages during embryogenesis and cancer cells are exposed to tension, compression shear stress; forces that can regulate cell proliferation differentiation. In the present study, we show stress blocks cycle progression in colon regulates expression of genes linked Wnt/beta-catenin, mitogen-activated protein kinase (MAPK) NFkappaB pathways. The stress-induced increase secreted Wnt inhibitor DKK1 requires p38 activation IkappaB kinase-beta. Activation beta-catenin, important...
The metabolism of the spleen tyrosine kinase inhibitor <i>N</i>4-(2,2-dimethyl-3-oxo-4-pyrid[1,4]oxazin-6-yl)-5-fluoro-<i>N</i>2-(3,4,5-trimethyoxyphenyl)-2,4-pyrimidinediamine (R406) and its oral prodrug <i>N</i>4-(2,2-dimethyl-4-[(dihydrogenphosphonoxy)methyl]-3-oxo-5-pyrid[1,4]oxazin-6-yl)-5-fluoro-<i>N</i>2-(3,4,5-trimethyoxyphenyl)-2,4-pyrimidinediamine disodium hexahydrate (R788, fostamatinib) was determined in vitro humans. R788 rapidly converted to R406 by human intestinal...
Aggregation-induced emission (AIE)-active luminogens (AIEgens) have demonstrated exciting potential for the application in cancer phototheranostics. However, simultaneously achieving tumor-activated bright emission, enhanced reactive oxygen species (ROS) generation, high tumor accumulation, and minimized ROS depletion remains challenging. Here, a metal–organic framework (MOF) hybrid AIEgen theranostic platform is designed, termed A-NUiO@DCDA@ZIF-Cu, composed of an AIEgen-loaded hydrophobic...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTProtein Molecular Mass to 1 Da by 13C, 15N Double-Depletion and FT-ICR SpectrometryAlan G. Marshall, Michael W. Senko, Weiqun Li, Ming Stephanie Dillon, Shenheng Guan, Timothy M. LoganView Author Information Center for Interdisciplinary Magnetic Resonance National High Field Laboratory 1800 E. Paul Dirac Drive Florida State University, Tallahassee, 32310 Cite this: J. Am. Chem. Soc. 1997, 119, 2, 433–434Publication Date (Web):January 15,...
The murine myeloid progenitor cell line 32D was recently shown to undergo monocytic differentiation when protein kinase C-delta (PKC-delta) overexpressed and activated by 12-O-tetradecanoylphorbol-13-acetate (TPA) (H. Mischak, J.H. Pierce, J. Goodnight, M.G. Kazanietz, P.M. Blumberg, J.F. Mushinski, Biol. Chem. 268:20110-20115, 1993). Tyrosine phosphorylation of PKC-delta occurred PKC-delta-transfected cells were stimulated TPA (W. Li, H. J.-C. Yu, L.-M. Wang, M.A. Heidaran, 269:2349-2352,...
Carbon coating is found to exacerbate the fracture of silicon nanoparticles during lithiation. Mechanics-based explanation and solution are proposed.
CNTs that consist of Co nanoparticles and atomically-dispersed atoms efficiently generate hydrogen from AB at a rate 7833 mL H 2 g −1 min .
The principal hallmark of Alzheimer's disease (AD) is neuron mitochondrial dysfunction, whereas miRNAs potentially play important roles. Nevertheless, efficacious mitochondria organelle therapeutic agents for treatment and management AD are highly advisable. Herein, we report a multifunctional DNA tetrahedron-based mitochondria-targeted platform, termed tetrahedral framework-based nanoparticles (TDFNs), which was modified with triphenylphosphine (TPP) mitochondria-targeting, cholesterol...
Here we propose a novel method for rapidly identifying proteins in complex mixtures. A list of candidate (including provision posttranslational modifications) is obtained by database searching, within specified mass range about the accurately measured (e.g., ±0.1 Da at 10 kDa) intact protein, capillary liquid chromatography electrospray ionization Fourier transform ion cyclotron resonance spectrometry (LC ESI FT-ICR MS). On alternate scans, LC infrared multiphoton dissociation (IRMPD) MS...
To investigate the function of protein kinase C (PKC)-δ, we mutated its ATP binding site by converting invariant lysine in catalytic domain (amino acid 376) to an arginine. Expression vectors containing wild type and mutant PKC-δ cDNAs were generated either with or without influenza virus hemagglutinin epitope tag. After expression 32D cells transfection, (PKC-δK376R) was not able phosphorylate itself pseudosubstrate region-derived substrate, indicating that PKC-δK376R inactive enzyme. PKC...
Inteins are polypeptide sequences found in a small set of primarily bacterial proteins that promote the splicing flanking pre-protein to generate mature protein products. can be engineered “split and inverted” configuration such product is cyclic consisting sequence linking two intein subdomains. We have split into retroviral expression system enable intracellular delivery library random peptides human cells. Cyclization could detected cell lysates using mass spectrometry. A functional...