A5068155662- Phagocytosis and Immune Regulation
- Cloud Computing and Resource Management
- IoT and Edge/Fog Computing
- Computer Graphics and Visualization Techniques
- Software-Defined Networks and 5G
- Cancer Mechanisms and Therapy
- Image Enhancement Techniques
- Cell death mechanisms and regulation
- Distributed and Parallel Computing Systems
- Quantum Computing Algorithms and Architecture
- Caching and Content Delivery
- Parallel Computing and Optimization Techniques
- Network Traffic and Congestion Control
- 3D Shape Modeling and Analysis
- Advanced MIMO Systems Optimization
- Fluid Dynamics Simulations and Interactions
- Image and Video Quality Assessment
- Advanced Neural Network Applications
- Advanced Image Processing Techniques
- Peer-to-Peer Network Technologies
- Quantum Information and Cryptography
- Computational Geometry and Mesh Generation
- Lattice Boltzmann Simulation Studies
- Telecommunications and Broadcasting Technologies
- Neural Networks and Reservoir Computing
Purdue University West Lafayette
2013-2024
Anhui University
2024
Massachusetts Institute of Technology
2018-2021
Purdue University System
2021
Microsoft Research (India)
2017-2018
Tsinghua University
2017
Purdue University Northwest
2011
Rigel (United States)
2004-2008
KTH Royal Institute of Technology
2008
Zhejiang University
2008
Ced-4 and Apaf-1 belong to a major class of apoptosis regulators that contain caspase-recruitment (CARD) nucleotide-binding oligomerization domains. Nod1, protein with an NH<sub>2</sub>-terminal CARD-linked domain COOH-terminal segment multiple leucine-rich repeats, was identified. Nod-1 found bind caspases long prodomains, but specifically activated caspase-9 promoted caspase-9-induced apoptosis. As reported for Apaf-1, Nod1 required both the CARD P-loop function. Unlike induced activation...
Recent studies indicate that Caenorhabditis elegans CED-4 interacts with and promotes the activation of death protease CED-3, this is inhibited by CED-9. Here we show a mammalian homolog CED-4, Apaf-1, can associate several proteases, including caspase-4, caspase-8, caspase-9, nematode CED-3 in cells. The interaction caspase-9 was mediated N-terminal CED-4-like domain Apaf-1. Expression Apaf-1 enhanced killing activity required Furthermore, promoted processing vivo . Bcl-X L , an...
Abstract Accumulating evidence suggests important roles for the receptor tyrosine kinase Axl in cancer progression, invasion, metastasis, drug resistance, and patient mortality, highlighting as an attractive target therapeutic development. We have generated characterized a potent selective small-molecule inhibitor, R428, that blocks catalytic procancerous activities of Axl. R428 inhibits with low nanomolar activity blocked Axl-dependent events, including Akt phosphorylation, breast cell...
Modern data center networks are commonly organized in multi-rooted tree topologies. They typically rely on equal-cost multipath to split flows across multiple paths, which can lead significant load imbalance. Splitting individual provide better balance, but is not preferred because of potential packet reordering that conventional wisdom suggests may negatively interact with TCP congestion control. In this paper, we revisit "myth" the context have regular topologies such as trees. We argue...
Retouching can significantly elevate the visual appeal of photos, but many casual photographers lack expertise to do this well. To address problem, previous works have proposed automatic retouching systems based on supervised learning from paired training images acquired before and after manual editing. As it is difficult for users acquire that reflect their preferences, we present in article a deep approach instead trained unpaired data, namely, set photographs exhibits style user likes,...
In multi-tenant datacenters, jobs of different tenants compete for the shared datacenter network and can suffer poor performance high cost from varying, unpredictable performance. Recently, several virtual abstractions have been proposed to provide explicit APIs tenant specify reserve clusters (VC) with both VMs required bandwidth between VMs. However, all existing proposals a fixed throughout entire execution job.
Improvements in color constancy have arisen from the use of convolutional neural networks (CNNs). However, patch-based CNNs that exist for this problem are faced with issue estimation ambiguity, where a patch may contain insufficient information to establish unique or even limited possible range illumination colors. Image patches ambiguity not only appear great frequency photographs, but also significantly degrade quality network training and inference. To overcome problem, we present fully...
In this paper, we introduce the Moving Least Squares Material Point Method (MLS-MPM). MLS-MPM naturally leads to formulation of Affine Particle-In-Cell (APIC) [Jiang et al. 2015] and Polynomial [Fu 2017] in a way that is consistent with Galerkin-style weak form discretization governing equations. Additionally, it enables new stress divergence effortlessly allows all MPM simulations run two times faster than before. We also develop Compatible (CPIC) algorithm on top MLS-MPM. Utilizing colored...
Physical simulators have been widely used in robot planning and control. Among them, differentiable are particularly favored, as they can be incorporated into gradient-based optimization algorithms that efficient solving inverse problems such optimal control motion planning. Therefore, rigid body recently their variants studied extensively. Simulating deformable objects is, however, more challenging compared to dynamics. The underlying physical laws of complex, the resulting systems orders...
3D visual computing data are often spatially sparse. To exploit such sparsity, people have developed hierarchical sparse structures, as multi-level voxel grids, particles, and hash tables. However, developing using these high-performance structures is challenging, due to their intrinsic complexity overhead. We propose Taichi , a new data-oriented programming language for efficiently authoring, accessing, maintaining structures. The offers high-level, structure-agnostic interface writing...
We have identified and characterized CLARP, a c aspase- l ike poptosis- r egulatory p rotein. Sequence analysis revealed that human CLARP contains two amino-terminal death effector domains fused to carboxyl-terminal caspase-like domain. The structure amino acid sequence of resemble those caspase-8, caspase-10, DCP2, Drosophila melanogaster protein in this study. Unlike however, important residues predicted be involved catalysis were lost the domain CLARP. Analysis with fluorogenic substrates...
The casp9 protein plays a critical role in apoptosis induced by variety of death stimuli. A regulator apoptosis, Apaf-1, binds to and activates pro-casp9 the presence cytochrome <i>c</i> dATP, requirement that is bypassed deletion WD-40 repeats located C-terminal half Apaf-1. In this report, we used constitutively active Apaf-1 mutant lacking repeat region study mechanism regulation activation. Mutational analysis revealed only small portion CED-4 homologous (residues 456–559) could be...
Load balancing is a foundational function of datacenter infrastructures and critical to the performance online services hosted in datacenters. As demand for cloud grows, expensive hard-to-scale dedicated hardware load balancers are being replaced with software that scale using distributed data plane runs on commodity servers. Software offer low cost, high availability flexibility, but suffer latency capacity per balancer, making them less than ideal applications either throughput, or both....
We present DiffTaichi, a new differentiable programming language tailored for building high-performance physical simulators. Based on an imperative language, DiffTaichi generates gradients of simulation steps using source code transformations that preserve arithmetic intensity and parallelism. A light-weight tape is used to record the whole program structure replay gradient kernels in reversed order, end-to-end backpropagation. demonstrate performance productivity our gradient-based learning...
We have identified and characterized Diva, which is a novel regulator of apoptosis. Sequence analysis revealed that Diva member the Bcl-2 family proteins containing homology domain 1, 2, 3, 4 (BH1, BH2, BH3, BH4) regions carboxyl-terminal hydrophobic domain. The expression mRNA was detected in multiple embryonic tissues but restricted to ovary testis adult mice. promoted death 293T, Ramsey, T47D cells as well primary sensory neurons, indicating proapoptotic protein. Significantly, lacks...
In multi-tenant datacenters, jobs of different tenants compete for the shared datacenter network and can suffer poor performance high cost from varying, unpredictable performance. Recently, several virtual abstractions have been proposed to provide explicit APIs tenant specify reserve clusters (VC) with both VMs required bandwidth between VMs. However, all existing proposals a fixed throughout entire execution job. paper, we first profile traffic patterns popular cloud applications, find...
A variety of structures in nature exhibit sparse, thin, and intricate features. It is challenging to investigate these structural characteristics using conventional numerical approaches since such features require highly refined spatial resolution capture therefore they incur a prohibitively high computational cost. We present novel framework for high-resolution topology optimization that delivers leaps simulation capabilities, by two orders magnitude, from the state-of-the-art approaches....
Load balancing is a foundational function of datacenter infrastructures and critical to the performance online services hosted in datacenters. As demand for cloud grows, expensive hard-to-scale dedicated hardware load balancers are being replaced with software that scale using distributed data plane runs on commodity servers. Software offer low cost, high availability flexibility, but suffer latency capacity per balancer, making them less than ideal applications either throughput, or both....
Apaf-1 is an important apoptotic signaling molecule that can activate procaspase-9 in a cytochromec/dATP-dependent fashion. Alternative splicing create NH2-terminal 11-amino acid insert between the caspase recruitment domain and ATPase domains or additional COOH-terminal WD-40 repeat. Recently, several isoforms have been identified tumor cell lines, but their expression tissues ability to remain poorly characterized. We performed analysis of normal tissue mRNAs examine relative forms...
Retouching can significantly elevate the visual appeal of photos, but many casual photographers lack expertise to do this well. To address problem, previous works have proposed automatic retouching systems based on supervised learning from paired training images acquired before and after manual editing. As it is difficult for users acquire that reflect their preferences, we present in paper a deep approach instead trained unpaired data, namely set photographs exhibits style user likes, which...
The highly anticipated 5G mmWave technology promises to enable many uplink-oriented, latency-critical applications (LCAs) such as Augmented Reality and Connected Autonomous Vehicles. Nonetheless, recent measurement studies have largely focused on its downlink performance. In this work, we perform a systematic study of the uplink performance commercial networks across 3 major US cities 2 mobile operators. Our makes three contributions. (1) It reveals that is geographically diverse,...