A5006788638- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune cells in cancer
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Studies on Chitinases and Chitosanases
- Epigenetics and DNA Methylation
- Invertebrate Immune Response Mechanisms
- Peptidase Inhibition and Analysis
- Adipose Tissue and Metabolism
- Muscle and Compartmental Disorders
- Bioactive Natural Diterpenoids Research
- Ubiquitin and proteasome pathways
- Lymphatic System and Diseases
- Bioactive Compounds and Antitumor Agents
- NF-κB Signaling Pathways
- Axon Guidance and Neuronal Signaling
Sanofi (United States)
2018-2024
University of Miami
2004-2015
Sylvester Comprehensive Cancer Center
2012-2013
Molina Center for Energy and the Environment
2007
Universidad de Cantabria
1998-1999
Centre Hospitalier Universitaire de Saint-Pierre
1998
Marqués de Valdecilla University Hospital
1996-1998
Instituto Nacional de la Salud
1996
Ced-4 and Apaf-1 belong to a major class of apoptosis regulators that contain caspase-recruitment (CARD) nucleotide-binding oligomerization domains. Nod1, protein with an NH<sub>2</sub>-terminal CARD-linked domain COOH-terminal segment multiple leucine-rich repeats, was identified. Nod-1 found bind caspases long prodomains, but specifically activated caspase-9 promoted caspase-9-induced apoptosis. As reported for Apaf-1, Nod1 required both the CARD P-loop function. Unlike induced activation...
Abstract IL-21 costimulates B cell proliferation and cooperatively with IL-4 promotes T cell-dependent Ab responses. Somewhat paradoxically, also induces apoptosis of cells. The present study was undertaken to more precisely define the expression IL-21R, using a novel mAb, circumstances by which growth vs death. IL-21R first detected during development, such that this receptor is expressed all mature lymphocytes. further up-regulated after activation, highest activated Functional studies...
The relationship between obesity and breast cancer (BC) has focused on serum factors. However, the mammary gland contains adipose tissue (AT) which may enable crosstalk adipocytes tumor cells contributing to macrophage recruitment. We hypothesize that AT (bAT) is inflamed in obese females plays a major role development. effects of this interplay chemotaxis were examined vitro, using co-cultures mouse macrophages, adipocytes. Macrophages exposed adipocyte paracrine factors leptin, CCL2 lauric...
We have identified and characterized Diva, which is a novel regulator of apoptosis. Sequence analysis revealed that Diva member the Bcl-2 family proteins containing homology domain 1, 2, 3, 4 (BH1, BH2, BH3, BH4) regions carboxyl-terminal hydrophobic domain. The expression mRNA was detected in multiple embryonic tissues but restricted to ovary testis adult mice. promoted death 293T, Ramsey, T47D cells as well primary sensory neurons, indicating proapoptotic protein. Significantly, lacks...
We have identified and characterized CIPER, a novel protein containing caspase recruitment domain (CARD) in its N terminus C-terminal region rich serine threonine residues. The CARD of CIPER showed striking similarity to E10, product the equine <i>herpesvirus</i>-2. formed homodimers via interacted with viral E10 but not several apoptosis regulators CARDs including ARC, RAIDD, RICK, caspase-2, caspase-9, or Apaf-1. Expression induced NF-κB activation, which was inhibited by dominant-negative...
Abstract Disseminated metastasis accounts for over 90% of breast cancer deaths. Recently, elevated serum levels a glycoprotein known as chitinase‐3 like‐protein‐1 (CHI3L1) has been correlated with poor prognosis and shorter survival patients metastatic cancer. In this study, we show that there are increased CHI3L1 in plasma tumor‐bearing mice both tumor cells immune express secrete CHI3L1. However, the biological physiological functions still unclear. We demonstrate while an inhibitory role...
We have identified and characterized Mtd, a novel regulator of apoptosis. Sequence analysis revealed that Mtd is member the Bcl-2 family proteins containing conserved BH1, BH2, BH3, BH4 regions carboxyl-terminal hydrophobic domain. In adult tissues, mRNA was predominantly detected in brain, liver, lymphoid while embryo thymus, lung, intestinal epithelium. Expression promoted death primary sensory neurons, 293T cells HeLa cells, indicating proapoptotic protein. Unlike all other known agonists...
Abstract Although much is known concerning the immunobiology of CD8+ T memory cells, initial events favoring generation cells remain poorly defined. Using a culture system that yields memory-like we show 1 day after Ag encounter, Ag-activated developed into but this optimally occurred 3 days encounter. Key phenotypic, functional, and molecular properties typify central were expressed within 48 h when activated cultured with IL-7 or IL-15 in absence following transfer normal mice. These data...
Semaphorins are a large family of molecules involved in axonal guidance during the development nervous system and have been recently shown to both angiogenic anti-angiogenic properties. Specifically, semaphorin 7A (SEMA7A) has reported chemotactic activity neurogenesis be an immune modulator through α1β1integrins. SEMA7A promote monocyte chemotaxis induce them produce proinflammatory mediators. In this study we explored role murine model breast cancer. We show that is highly expressed by...
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IL-7 and IL-15 are important cytokines for CD8 memory T cells. However, the extent that is essential cell remains unclear because blocking in vivo results near complete inhibition of development with few mature cells exhibiting functional abnormalities. To bypass this complication, was examined utilizing a mouse model where transgenic IL-7Ralpha selectively expressed thymus IL-7Ralpha(-/-) mice. corrected but resulting peripheral were essentially non-responsive. Activation IL-7R-defective...
Elevated levels of chitinase-3-like-1 (CHI3L1) are associated with poor prognosis, shorter recurrence-free intervals and low survival in breast cancer patients. Breast often metastasizes to the lung. We hypothesized that molecules expressed "pre-metastatic" lung microenvironment could support newly immigrant tumor cells by providing growth angiogenic factors. Macrophages known play an important role releasing pro-angiogenic molecules. Using mouse mammary models, we have previously shown...
The bcl-2 protooncogene has been shown to provide a survival signal self-reactive B cells, but it fails override their developmental arrest after encounter with antigen. Furthermore, constitutive expression of in cells does not promote the development autoimmune disease most strains mice, indicating that signals other than those conferred by are required for long-term and differentiation vivo. To further examine factors pathogenesis disease, we have assessed effect overexpression on...