A5077882567- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Parathyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Genetic Syndromes and Imprinting
- Neuroendocrine Tumor Research Advances
- Head and Neck Anomalies
- Health Systems, Economic Evaluations, Quality of Life
- Diversity and Career in Medicine
- Primary Care and Health Outcomes
- Heart Failure Treatment and Management
- Pancreatic and Hepatic Oncology Research
- Venous Thromboembolism Diagnosis and Management
- Adrenal Hormones and Disorders
- Lipoproteins and Cardiovascular Health
- Medication Adherence and Compliance
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Cardiac Health and Mental Health
Clinical Research Institute
2015-2025
Medical College of Wisconsin
2015-2024
Yale University
2007-2024
Patient-Centered Outcomes Research Institute
2024
Twitter (United States)
2024
Indianapolis Zoo
2024
West Los Angeles College
2024
Jackson College
2024
Kaiser Permanente Fontana Medical Center
2024
Ann Arbor Center for Independent Living
2024
Primary hyperparathyroidism (pHPT) is a common clinical problem for which the only definitive management surgery. Surgical has evolved considerably during last several decades.To develop evidence-based guidelines to enhance appropriate, safe, and effective practice of parathyroidectomy.A multidisciplinary panel used PubMed review medical literature from January 1, 1985, July 2015. Levels evidence were determined using American College Physicians grading system, recommendations discussed...
<h3>Background</h3> Myeloid cells are an abundant leukocyte in many types of tumors and contribute to immune evasion. Expression the enzyme arginase 1 (Arg1) is a defining feature immunosuppressive myeloid leads depletion L-arginine, nutrient required for T cell natural killer (NK) proliferation. Here we use CB-1158, potent orally-bioavailable small-molecule inhibitor arginase, investigate role Arg1 regulating anti-tumor immunity. <h3>Methods</h3> CB-1158 was tested ability block...
Clinical and economic outcomes after thyroidectomy/parathyroidectomy in adults have demonstrated disparities based on patient age race/ethnicity; there is a paucity of literature pediatric endocrine outcomes.The objective was to examine the clinical demographic predictors thyroidectomy/parathyroidectomy.This study cross-sectional analysis Healthcare Cost Utilization Project-National Inpatient Sample hospital discharge information from 1999-2005. All patients who underwent were included....
European studies have shown that the use of routine calcitonin screening for detection medullary thyroid cancer (MTC) in patients with nodules increases occult MTC and may improve patient outcomes. Calcitonin has not been recommended recent U.S. practice guidelines.Our objective was to determine cost-effectiveness (C/E) adult United States.A decision model developed a hypothetical group presenting evaluation States. Patients were screened using current American Thyroid Association guidelines...
In Brief Context: Thyroid disease is common, and thyroidectomy a mainstay of treatment for many benign malignant thyroid conditions. Overall, associated with favorable outcomes, particularly if experienced surgeons perform it. Objective: To examine racial differences in clinical economic outcomes patients undergoing the United States. Design, Setting, Patients: The nationwide inpatient sample was used to identify admissions from 1999 2004, using ICD-9 procedure codes. Race other demographic...
Objectives. 1) To examine recent change in prevalence and Medicare-associated charges for non-invasive/minimally invasive evaluation treatment of nonspecific low back pain (LBP); 2) to magnetic resonance imaging (MRI) utilization appropriateness older adults with chronic (CLBP). Design. Two cross-sectional surveys national (1991–2002) Pennsylvania (2000–2002) Medicare data; patients aged ≥65 years CLBP. Setting. Outpatient data. Participants. Patients ≥ 65 LBP. Measurements. Study 1: Part A...
In Brief Objective: Higher surgeon volume is associated with improved patient outcomes. This finding has prompted recommendations for increasing specialization and referrals to high-volume surgeons, yet their implementation in clinical practice not been measured. Methods: We performed cross-sectional analyses using 1999 2005 discharge information from the Health Care Utilization Project National Inpatient Sample measure whether number of procedures by surgeons increased over time. Procedures...
Adrenocortical carcinoma (ACC) is a rare but aggressive endocrine tumor, and the prognostic factors associated with long-term outcomes after surgical resection remain poorly defined.To define clinicopathological variables recurrence-free survival (RFS) overall (OS) curative of ACC to propose nomograms for individual risk prediction.Nomograms predict RFS OS were proposed using multi-institutional cohort patients who underwent curative-intent surgery at 13 major institutions in United States...
Background— Little is known about the contemporary use of intra-aortic balloon pump (IABP) and other mechanical circulatory support (O-MCS) devices in patients undergoing percutaneous coronary intervention (PCI) setting cardiogenic shock. Methods Results— We identified 76 474 who underwent PCI shock at one 1429 National Cardiovascular Data Registry CathPCI participating hospitals from 2009 to 2013. Temporal trends hospital-level variation IABP O-MCS were evaluated. No was used 41 286 (54%)...
Background: Patients hospitalized with COVID-19 have an increased incidence of thromboembolism. The role extended thromboprophylaxis after hospital discharge is unclear. Objective: To determine whether anticoagulation superior to placebo in reducing death and thromboembolic complications among patients discharged hospitalization. Design: Prospective, randomized, double-blind, placebo-controlled clinical trial. (ClinicalTrials.gov: NCT04650087) Setting: Done during 2021 2022 127 U.S....
Spermatogonial stem cells (SSCs) maintain spermatogenesis by self-renewal and generation of spermatogonia committed to differentiation. Under certain in vitro conditions, SSCs from both neonatal adult mouse testis can reportedly generate multipotent germ cell (mGC) lines that have characteristics differentiation potential similar embryonic (ES) cells. However, mGCs generated different laboratories showed characteristics, i.e., some retain their SSC properties lost them completely. This...
To determine whether surgical volume influences the cause of operative failures after parathyroidectomy for hyperparathyroidism.The success rate hyperparathyroidism from high-volume centers exceeds 95%, but some patients have unsuccessful parathyroidectomies. Although failure can be due to hyperfunctioning parathyroid glands in ectopic locations, less experienced surgeons may more likely miss an abnormal normal anatomic which we describe as "preventable failure."We used 2 prospective...