A5064333133- Thyroid Disorders and Treatments
- Adenosine and Purinergic Signaling
- Thyroid Cancer Diagnosis and Treatment
- Circadian rhythm and melatonin
- Growth Hormone and Insulin-like Growth Factors
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Sexual Differentiation and Disorders
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Receptor Mechanisms and Signaling
- Child and Adolescent Health
- Thyroid and Parathyroid Surgery
- Neuroscience and Neuropharmacology Research
- Congenital heart defects research
- Neuroendocrine regulation and behavior
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
- Health and Medical Research Impacts
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sleep and Wakefulness Research
- Genetics and Neurodevelopmental Disorders
- Neuropeptides and Animal Physiology
- Health Sciences Research and Education
- Adrenal Hormones and Disorders
Florida Department of Health
2020-2024
John Brown University
2024
Brown University
2022-2023
University of Florida
2012-2021
Florida College
2014-2021
Coral Reef Alliance
2020
Dallas County
2020
University of New Orleans
2020
UF Health Shands Hospital
2015-2019
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2019
Background: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis is influenced by coexisting medical conditions patient preference. This document describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist subspecialty physicians others providing care patients with this condition. Methods: The American Thyroid Association (ATA) previously cosponsored were...
Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis is influenced by coexisting medical conditions patient preference. This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist subspeciality physicians others providing care patients with this condition.The development these was commissioned American Thyroid Association in association...
In vitro autoradiography with 125I-labeled melatonin was used to examine binding sites in human hypothalamus. Specific localized the suprachiasmatic nuclei, site of a putative biological clock, and not apparent other hypothalamic regions. consistently found nuclei hypothalami from adults fetuses. Densitometric analysis competition experiments varying concentrations showed monophasic curves, comparable half-maximal inhibition values for (150 picomolar) fetuses (110 picomolar). Micromolar...
Clinical and economic outcomes after thyroidectomy/parathyroidectomy in adults have demonstrated disparities based on patient age race/ethnicity; there is a paucity of literature pediatric endocrine outcomes.The objective was to examine the clinical demographic predictors thyroidectomy/parathyroidectomy.This study cross-sectional analysis Healthcare Cost Utilization Project-National Inpatient Sample hospital discharge information from 1999-2005. All patients who underwent were included....
An A1-adenosine receptor has been cloned from a rat brain cDNA library using probe generated by the polymerase chain reaction. The encodes protein of 327 amino acids which is 91% identical to recently dog (RDC7). Expression in COS-6M and NIH 3T3 cells resulted ligand binding functional activity characteristics an that coupled inhibition adenylyl cyclase. Examination distribution mRNA Northern blot analysis showed it highly expressed brain, spinal cord, testis, white adipose tissue. In situ...
We tested the hypothesis that chemotherapy-induced gonadal damage is proportional to degree of activity during treatment. Thirty studies evaluated function after cyclophosphamide therapy for renal disease or combination chemotherapy Hodgkin's acute lymphocytic leukemia provided data analysis. Data were stratified according sex, illness, chemotherapeutic regimen and dose, pubertal stage at time Chemotherapy-induced was more likely occur in patients who treated when sexually mature compared...
A novel adenosine receptor subtype has been cloned from a rat brain cDNA library using probe generated by the polymerase chain reaction. The cDNA, designated RFL9, encodes protein of 332 amino acids. structure RFL9 is most similar to that recently A2-adenosine receptor, with sequence identity 73% within presumed seven transmembrane domains. Expression in COS-6M cells resulted ligand binding and functional activity characteristics an coupled positively adenylyl cyclase. Examination tissue...
It has been suggested that complete catch-up growth is achieved with treatment in patients juvenile acquired hypothyroidism. We tested this assumption by examining long-term 18 girls (mean [+/- SD] age, 11.4 +/- 2.7 years; bone 6.2 3.1 years) and 6 boys (age, 10.6 4.7 6.4 severe primary hypothyroidism (serum thyroxine level 1.1 0.3 micrograms per deciliter [13 4 nmol liter]). At diagnosis, heights were 4.04 0.5 3.15 0.4 SD below the mean for age of normal boys, respectively. The treated...
The cardiac conduction system is a network of cells responsible for the rhythmic and coordinated excitation heart. Components murine system, including peripheral Purkinje fibers, are morphologically indistinguishable from surrounding cardiomyocytes, paucity molecular markers exists to identify these cells. develops in close association with endocardium. Using recently identified CCS-lacZ line reporter mice, which lacZ expression delineates embryonic fully mature we tested ability several...
Rho-associated kinases (Rho kinases), which are downstream effectors of RhoA GTPase, regulate diverse cellular functions including actin cytoskeletal organization. We have demonstrated that Rho also direct the early stages chick and mouse embryonic morphogenesis. observed kinase transcripts were enriched in cardiac mesoderm, lateral plate mesoderm neural plate. Treatment neurulating embryos with Y27632, a specific inhibitor kinases, blocked migration fusion bilateral heart primordia,...
The antithyroid drugs propylthiouracil (PTU) and methimazole (MMI) have played central roles in the management of hyperthyroidism for more than 50 yr. Although both effectively control hyperthyroidism, observations over several decades shown that MMI its prodrug carbimazole are better PTU controlling severe having higher adherence rates, causing less toxicity, especially when prescribed lower doses (1).Thishas led to therecommendationthatMMIshouldbe first-line drug therapy is initiated,...
Using the polymerase chain reaction, an A3 adenosine receptor has been cloned from hypophysial par tuberalis of sheep. The clone encodes a 317-amino acid protein that is 72% identical to rat receptor. In contrast rat, where abundant mRNA transcript found primarily in testis, sheep most lung, spleen, and pineal gland present moderate levels brain, kidney, testis. agonist N6-amino[125I]iodobenzyladenosine binds with high affinity (Kd congruent 6 nm) specificity recombinant receptors expressed...
Abstract Objective Periventricular white matter injury (PWMI) is the major cause of cerebral palsy and cognitive impairment in prematurely born infants. PWMI characterized by reductions myelination cerebrocortical volumes associated with secondary ventriculomegaly. In neonatal rodents, these features can be induced rearing chronic hypoxia or activation A1 adenosine receptors. We determined: (1) whether altered maturation development one more oligodendrocyte (OL) lineage stages plays a role...
The antithyroid drugs propylthiouracil and methimazole were introduced for clinical use about 60 yr ago are estimated to be used in more than 6000 children adolescents per year the United States. Over years that these medications have been used, reports of adverse events involving hepatotoxicity appeared. To date, there has not a systematic comparative evaluation associated with drug use.Our objective was assess safety profiles by age U.S. Food Drug Administration's Adverse Event Reporting...