A5059798193- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Thyroid and Parathyroid Surgery
- Parathyroid Disorders and Treatments
- Lung Cancer Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Electrolyte and hormonal disorders
- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Radiomics and Machine Learning in Medical Imaging
- Esophageal and GI Pathology
- CAR-T cell therapy research
- Advanced Biosensing Techniques and Applications
- Immunotherapy and Immune Responses
- Heart Failure Treatment and Management
- Health and Medical Research Impacts
- Neuroendocrine Tumor Research Advances
- Immune cells in cancer
- Thyroid Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Single-cell and spatial transcriptomics
- Genetic Syndromes and Imprinting
- Chronic Kidney Disease and Diabetes
- Hemodynamic Monitoring and Therapy
University Hospital Bonn
2007-2022
Memorial Sloan Kettering Cancer Center
2021
German Cancer Research Center
2004-2020
Heidelberg University
2004-2020
University Hospital Heidelberg
2004-2020
Yale University
2008-2020
University Medical Centre Mannheim
2020
California Pacific Medical Center
2016
Creative Research Enterprises (United States)
2016
Moffitt Cancer Center
2016
Clinical and economic outcomes after thyroidectomy/parathyroidectomy in adults have demonstrated disparities based on patient age race/ethnicity; there is a paucity of literature pediatric endocrine outcomes.The objective was to examine the clinical demographic predictors thyroidectomy/parathyroidectomy.This study cross-sectional analysis Healthcare Cost Utilization Project-National Inpatient Sample hospital discharge information from 1999-2005. All patients who underwent were included....
<h3>Importance</h3> Adjuvant chemotherapy offers a survival benefit to number of staging scenarios in non–small-cell lung cancer. Variable recovery from cancer surgery may delay patient’s ability tolerate adjuvant chemotherapy, yet the urgency initiation is unclear. <h3>Objective</h3> To assess differences according time interval between resection and postoperative determine association treatment timing efficacy. <h3>Design, Setting, Participants</h3> This retrospective observational study...
Eosinophils have been identified as a prognostic marker in immunotherapy of melanoma and suggested to contribute anti-tumor host defense. However, the influence immune checkpoint inhibitors (ICI) on eosinophil population is poorly studied. Here, we applied routine laboratory tests, multicolor flow cytometry, RNA microarray analysis, bio-plex assay analyze circulating eosinophils related serum inflammatory factors 32 patients treated with pembrolizumab or combination nivolumab ipilimumab. We...
In Brief Objective: This study had 2 aims: (1) to assess the timing and magnitude of psychological neurocognitive changes before after parathyroidectomy (2) examine correlations between in serum biomarkers symptoms performance. Background: Psychological are common patients with primary hyperparathyroidism (pHPT), but associations these have not been established. Methods: prospective cohort carried out at a large tertiary care referral center from 2004 2008 screened all adult biochemical...
Cancer research has made great progress in the recent years. With increasing number of options diagnosis and therapy implementation tumorboards (TUBs) become standard procedure treatment cancer patients. Adherence tests on tumor board decisions are intended to enable quality assurance enhancement for work boards order continuously optimize patients.Subject this study was adherence recommendations three 14 tumorboards, which take place weekly Center Integrated Oncology (CIO) at University...
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in compositions within alveolar space peripheral blood a cohort COPD patients controls. Myeloid cells were largest compartment with invading monocytes proliferating macrophages elevated COPD. Modeling cell-to-cell communication, signaling pathway usage, transcription factor binding predicts TGF-β1 to be...
Abstract Despite the epidemics of chronic obstructive pulmonary disease (COPD), cellular and molecular mechanisms this are far from being understood. Here, we characterize classify composition within alveolar space peripheral blood COPD patients control donors using a clinically applicable single-cell RNA-seq technology corroborated by advanced computational approaches for: machine learning-based cell-type classification, identification differentially expressed genes, prediction metabolic...
Interstitial lung disease (ILD) is the most common form of pulmonary impairment in patients with rheumatoid arthritis (RA). However, RA or other arthritic diseases such as psoriatic (PsA) peripheral spondyloarthritis (pSpA) are at a higher risk developing several diseases, chronic obstructive (COPD), compared to without arthritis. This review aims summarizing current knowledge on prevalence above-mentioned forms arthritis, challenges faced by studies detecting well possible treatment...
In Brief Objective: Evidence-based surgery is predicated on the quality of published literature. We measured manuscripts selected by peer review and identified predictors excellence. Methods: One hundred twenty clinical were randomly from 1998 in 5 eminent peer-reviewed medical journals. Manuscripts blinded for author, institution, journal origin. Four surgeons 4 methodologists evaluated using novel instruments based subject selection, study protocol, statistical analysis/inference,...