A5006849637- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Pleural and Pulmonary Diseases
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Economic and Financial Impacts of Cancer
- Pancreatic and Hepatic Oncology Research
- COVID-19 and healthcare impacts
- Lung Cancer Research Studies
- Tracheal and airway disorders
- Cancer Cells and Metastasis
- Health Systems, Economic Evaluations, Quality of Life
- Head and Neck Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Genomics and Diagnostics
- Esophageal and GI Pathology
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Colorectal Cancer Screening and Detection
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- Cancer Diagnosis and Treatment
Yale University
2016-2025
Yale Cancer Center
2009-2025
American College of Surgeons
2016-2025
New York Proton Center
2021-2024
University of New Haven
2010-2023
The University of Texas Southwestern Medical Center
2022
Southwestern Medical Center
2022
Thoracic Surgery Foundation
2014-2021
City of Hope
2021
Yale New Haven Hospital
2014-2020
Single-cell network analysis demonstrates species-conserved functional roles for pulmonary alveolar cell types.
The extraordinary demands of managing the COVID-19 pandemic has disrupted world's ability to care for patients with thoracic malignancies. As a hospital's population increases and hospital resources are depleted, provide surgical is progressively restricted, forcing surgeons prioritize among their cancer populations. Representatives from multiple cancer, surgical, research organizations have come together guide triaging malignancies as impact evolves each hospital.
Each year, the National Cancer Database (NCDB) collects and analyzes data used in reports to support research, quality measures, Commission on program accreditation. Because models generate these have been historically stable, year-to-year variances attributed changes within cancer rather than modeling. submissions 2020 were anticipated be significantly different from prior years because of COVID-19 pandemic. This study involved a validation analysis observed expected NCDB comparison with...
Importance Prior reports demonstrated that patients with cancer experienced worse outcomes from pandemic-related stressors and COVID-19 infection. Patients certain malignant neoplasms, such as high-risk gastrointestinal (HRGI) cancers, may have been particularly affected. Objective To evaluate disruptions in care among HRGI cancers during the pandemic, assessing for signs of long-term changes populations survival. Design, Setting, Participants This retrospective cohort study used data...
<h3>Importance</h3> Directing patients to safer hospitals for complex cancer surgery (regionalization) may prevent thousands of mortalities in the United States. <h3>Objective</h3> To understand potential individuals move hospitals: what would inspire them travel (motivators), challenges they face (barriers), and enable (facilitators). <h3>Design, Setting, Participants</h3> This nationally representative online survey study asked respondents consider at their local hospital or a specializing...
Cigarette smoke (CS) and viruses promote the inflammation remodeling associated with chronic obstructive pulmonary disease (COPD). The MAVS/RIG-I-like helicase (MAVS/RLH) pathway inflammasome-dependent innate immune pathways are important mediators of these responses. At baseline, MAVS/RLH is suppressed, this inhibition must be reversed to engender tissue effects; however, mechanisms that mediate activation repression have not been defined. In addition, regulation contribution signaling in...
Purpose The prevalence of minimally invasive lung cancer surgery using video-assisted thoracic (VATS) has increased dramatically over the past decade, yet recent studies have suggested that lymph node evaluation during VATS lobectomy is inadequate. We hypothesized approach to for stage I resulted in a longitudinal outcome was not inferior thoracotomy. Patients and Methods > 65 years age who had undergone between 2002 2013 were analyzed within Society Thoracic Surgeons General Surgery...
<h3>Background</h3> Checkpoint inhibitors (CPI) have revolutionized the treatment of metastatic melanoma, but most patients treated with CPI eventually develop progressive disease. Local therapy including surgery, ablation or stereotactic body radiotherapy (SBRT) may be useful to manage limited progression, criteria for patient selection not been established. Previous work has suggested progression-free survival (PFS) after local is associated patterns immunotherapy failure, this studied in...
Lung cancer treatment has become increasingly dependent upon invasive biopsies to profile tumors for personalized therapy. Recently, tumor expression of programmed death-ligand 1 (PD-L1) gained interest as a potential predictor response immunotherapy. Circulating biomarkers present an opportunity profiling without the risks procedures. We characterized PD-L1 within populations nucleated cells in peripheral blood lung patients hopes expanding role liquid biopsy this setting.