A5056175467- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Genetic and phenotypic traits in livestock
- Lung Cancer Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- HIV Research and Treatment
- Bioinformatics and Genomic Networks
- Molecular Biology Techniques and Applications
- Microbial infections and disease research
- Cancer-related gene regulation
- Gene expression and cancer classification
- Model-Driven Software Engineering Techniques
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- Genetics and Plant Breeding
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- AI in cancer detection
Yale University
2016-2025
Shanghai Jiao Tong University
2020
Yale Cancer Center
2017-2019
Yale New Haven Health System
2017-2018
American College of Surgeons
2016
The American College
2016
American College of Financial Services
2016
Memorial Sloan Kettering Cancer Center
2014
Beijing Forestry University
2014
Dalian University of Technology
2011-2012
Large-scale genome-wide association studies (GWAS) have identified many loci associated with body mass index (BMI), but few focused on obesity as a binary trait. Here we report the results of GWAS and candidate SNP genotyping study obesity, including extremely obese cases never overweight controls well families segregating extreme thinness. We first performed 520 (BMI>35 kg/m2) 540 control subjects (BMI<25 kg/m2), measures obesity-related traits. subsequently followed up obesity-associated...
<h3>Importance</h3> Adjuvant chemotherapy offers a survival benefit to number of staging scenarios in non–small-cell lung cancer. Variable recovery from cancer surgery may delay patient’s ability tolerate adjuvant chemotherapy, yet the urgency initiation is unclear. <h3>Objective</h3> To assess differences according time interval between resection and postoperative determine association treatment timing efficacy. <h3>Design, Setting, Participants</h3> This retrospective observational study...
Abstract Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe COVID-19. However, signatures associated with immunopathology poorly understood. Here we use multi-omics single-cell analysis to probe dynamic hospitalized patients stable or progressive course of COVID-19, explore V(D)J repertoires, and assess cellular effects tocilizumab. Coordinated profiling gene expression cell lineage protein markers shows that S100A hi /HLA-DR lo classical monocytes...
Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of biologically relevant mechanisms remains a central challenge. Here, we perform parallel vivo functional analysis 10 ASD genes at behavioral, structural, and circuit levels zebrafish mutants, revealing both unique overlapping effects loss function. Whole-brain mapping identifies forebrain cerebellum as most significant contributors brain size differences, while regions involved sensory-motor control,...
Next generation sequencing (NGS) has been leading the genetic study of human disease into an era unprecedented productivity. Many bioinformatics pipelines have developed to call variants from NGS data. The performance these depends crucially on variant caller used and calling strategies implemented. We studied four prevailing callers, SAMtools, GATK, glftools Atlas2, using single-sample multiple-sample variant-calling strategies. Using same aligner, BWA, we built three applied whole exome...
Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral integration and latency. However, epigenetic changes in the HIV-1-infected host genome have not been well characterized. Here, we report first large-scale epigenome-wide association study DNA methylation HIV-1 infection. We recruited HIV-infected (n = 261) uninfected 117) patients from Veteran Aging Cohort Study (VACS) all samples were profiled 485,521 CpG sites extracted blood. After adjusting cell type...
Summary Population stratification is an important issue in case–control studies of disease‐marker association. Failure to properly account for population structure can lead spurious association or reduced power. In this article, we compare the performance six methods correcting studies. These include genomic control (GC), EIGENSTRAT, principal component‐based logistic regression (PCA‐L), LAPSTRUCT, ROADTRIPS, and EMMAX. We also uncorrected Armitage test comparison. simulation studies,...
Describing the genetic diversity in gene pool of crops will provide breeders with novel resources for varietal improvement. Nested Association Mapping (NAM) populations are uniquely suited characterizing parental through shuffling and fixation haplotypes. Here, we describe a set 1879 rice NAM lines created selfing single-seed descent F
Chronic stress has a significant impact on obesity. However, how influences obesity remains unclear. We conducted an epigenome-wide DNA methylation association analysis of (N = 510) and examined whether cumulative influenced the body weight. identified 20 CpG sites associated with mass index at false discovery rate q < 0.05, including novel site, cg18181703, in suppressor cytokine signaling 3 (SOCS3) gene (coefficient β −0.0022, FDR 4.94 × 10−5). The interaction between cg18181703 adverse...
Abstract Transfer RNA-derived fragments (tRFs) are a new class of small non-coding RNAs and play important roles in biological physiological processes. Prediction tRF target genes binding sites is crucial understanding the functions tRFs molecular mechanisms human diseases. We developed publicly accessible web-based database, tRFtarget (http://trftarget.net), for prediction. It contains computationally predicted interactions between mRNA transcripts using two state-of-the-art prediction...
Mapping expression quantitative trait loci (eQTLs) has provided insight into gene regulation. Compared to cis-eQTLs, the regulatory mechanisms of trans-eQTLs are less known. Previous studies suggest that may regulate remote genes by altering nearby genes. Trans-association been studied in mediation analysis with a single mediator. However, prior applications one mediator prone model misspecification due correlations between Motivated from observation more likely associate than cis-gene...
The incorporation of developmental control mechanisms growth has proven to be a powerful tool in mapping quantitative trait loci (QTL) underlying trajectories. A theoretical framework for implementing QTL strategy with laws been established. This can generalized an arbitrary number time points, where is measured, and becomes computationally more tractable, when the assumption variance stationarity made. In practice, however, this likely violated age-specific traits due scale effect. article,...
Mutations in GBA1 gene result defective acid β-glucosidase and the complex phenotype of Gaucher disease (GD) related to accumulation glucosylceramide-laden macrophages. The is highly variable even among patients harboring identical mutations. We hypothesize that modifier gene(s) underlie phenotypic diversity GD performed a GWAS study Ashkenazi Jewish with type 1 (GD1), homozygous for N370S mutation. Patients were assigned mild, moderate, or severe categories using composite severity scoring...
Abstract A dysregulated immune response against the SARS-CoV-2 virus plays a critical role in severe COVID-19. However, molecular and cellular mechanisms by which causes lethal immunopathology are poorly understood. Here, we utilize multiomics single-cell analysis to probe dynamic responses patients with stable or progressive manifestations of COVID-19, assess effects tocilizumab, an anti-IL-6 receptor monoclonal antibody. Coordinated profiling gene expression cell lineage protein markers...