A5056969786- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Sepsis Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Neonatal Respiratory Health Research
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Family and Patient Care in Intensive Care Units
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Intensive Care Unit Cognitive Disorders
- Kawasaki Disease and Coronary Complications
- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Dialysis and Renal Disease Management
- Gastrointestinal motility and disorders
- Child and Adolescent Health
- Central Venous Catheters and Hemodialysis
- Injury Epidemiology and Prevention
- Electrolyte and hormonal disorders
- Anesthesia and Sedative Agents
- Spinal Cord Injury Research
- Thermal Regulation in Medicine
Hospital General Universitario Gregorio Marañón
2016-2025
Universidad Complutense de Madrid
1996-2024
Instituto de Salud Carlos III
2012-2024
Universidad Nacional Autónoma de México
2024
Instituto Politécnico Nacional
2024
Comunidad de Madrid
2018-2024
Hospital Materno-Infantil
2016-2024
Public Health Department
2024
United States Fish and Wildlife Service
2017-2023
Louisiana Department of Wildlife and Fisheries
2023
Abstract Background Point-of-care ultrasound (POCUS) is nowadays an essential tool in critical care. Its role seems more important neonates and children where other monitoring techniques may be unavailable. POCUS Working Group of the European Society Paediatric Neonatal Intensive Care (ESPNIC) aimed to provide evidence-based clinical guidelines for use critically ill children. Methods Creation international Euro-American panel paediatric neonatal intensivists expert systematic review...
Abstract Background Multisystem inflammatory syndrome temporally associated with COVID-19 (MIS-C) has been described as a novel and often severe presentation of SARS-CoV-2 infection in children. We aimed to describe the characteristics children admitted Pediatric Intensive Care Units (PICUs) presenting MIS-C comparison those other features such pneumonia. Methods A multicentric prospective national registry including 47 PICUs was carried out. Data from confirmed or fulfilling criteria (with...
Objective To study the expression of HLA-G on peripheral blood mononuclear cells (PBMC) from HIV-1-infected individuals in order to determine whether this molecule is induced as a consequence HIV-1 infection. Design A total 23 HIV-positive different stages disease were studied. Methods Flow cytometric analysis and Western blot used measure PBMC obtained control individuals. Results Most monocytes express HLA-G, whereas only very low proportion healthy molecule. When T lymphocytes infections...
Spermatogonial stem cells (SSCs) maintain spermatogenesis by self-renewal and generation of spermatogonia committed to differentiation. Under certain in vitro conditions, SSCs from both neonatal adult mouse testis can reportedly generate multipotent germ cell (mGC) lines that have characteristics differentiation potential similar embryonic (ES) cells. However, mGCs generated different laboratories showed characteristics, i.e., some retain their SSC properties lost them completely. This...
Abstract Spinal cord injury (SCI) is followed by a secondary degenerative process that includes cell death. We have previously demonstrated the chemokine CXCL10 up‐regulated following SCI and plays critical role in T‐lymphocyte recruitment to sites of inhibition angiogenesis; antibody‐mediated functional blockade reduced inflammation while enhancing angiogenesis. hypothesized, based on these findings, environment established anti‐CXCL10 antibody treatment would support greater survival...
Celiac disease (CD) is a disorder characterized by deregulated immune response to ingested wheat gluten and related cereal proteins in susceptible individuals. It has been considered that the onset of CD mediated skewed Th1 response. However, participation Th17 cells pathogenesis disease, key cell population other autoimmune disorders, not studied detail. We have investigated presence mucosa active patients their functional implications disease.T obtained from duodenum biopsies 15 untreated...
Abstract After spinal cord injury, there is a chemoattractant‐mediated inflammatory response that associated with secondary degeneration. The chemoattractant CXCL10 recruits CD4 Th1 cells via the CXCR3A receptor and inhibits growth chemotaxis of endothelial CXCR3B receptor. To test hypothesis angiogenesis following we assayed brainstems cords cord‐injured mice treated anti‐CXCL10 antibodies for expression angiogenesis‐associated genes quantified blood vessels within their cords. Brainstem...
Inflammation plays a critical role in the secondary degenerative response to spinal cord injury (SCI). The influx of inflammatory cells following SCI is preceded by expression specific chemoattractants, including chemokines. chemokine CXCL10 potent T lymphocyte recruiter and has been strongly implicated pathology many CNS disorders. We have previously demonstrated that exacerbates degeneration blocking function prior SCI. Here we administered neutralizing antibodies against 1 h after order...
ABSTRACT Although the use of RGB photometry has exploded in last decades due to advent high-quality and inexpensive digital cameras equipped with Bayer-like colour filter systems, there is surprisingly no catalogue bright stars that can be used for calibration purposes. Since their excessive brightness, accurate enough spectrophotometric measurements typically cannot performed modern large telescopes, we have employed historical 13-colour medium-narrow-band photometric data, gathered quite...
This review summarizes current literature about the relationships between macro and microcirculation their practical clinical implications in children with septic shock.
There have been various forms of mesenchymal stem cell-like (MSC-like) cells isolated from umbilical cords (UCs). The isolation cord lining (ULSCs) may be great value for those interested in a possible treatment to several disease/disorders. Unlike blood cells, these are unique because they can expanded therapeutically relevant numbers and cryopreserved different uses. Here we efficiently isolate small segment pre- postnatal UCs, obtain amounts ULSCs within 3 weeks. We demonstrate their...
Continuous renal replacement therapy (CRRT) is the treatment of choice for critically ill children with acute kidney injury. Hypotension after starting CRRT frequent but very few studies have analyzed its incidence and clinical relevance. A prospective, observational study was performed including treated between 2010 2014. Hemodynamic data connection characteristics were collected before, during, 60 min circuit connection. defined as a decrease in > 20% mean arterial pressure from baseline...