A5091347853- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Clinical Nutrition and Gastroenterology
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Immunodeficiency and Autoimmune Disorders
- Tracheal and airway disorders
- Systemic Lupus Erythematosus Research
- Pediatric Hepatobiliary Diseases and Treatments
- Abdominal Surgery and Complications
- Transplantation: Methods and Outcomes
- Immunotherapy and Immune Responses
- Organ Donation and Transplantation
- Congenital Anomalies and Fetal Surgery
- Diphtheria, Corynebacterium, and Tetanus
- Intestinal Malrotation and Obstruction Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Celiac Disease Research and Management
- Esophageal and GI Pathology
- Blood disorders and treatments
- Neonatal Health and Biochemistry
- Monoclonal and Polyclonal Antibodies Research
- Urinary Tract Infections Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
Hospital Universitario La Paz
2013-2022
University of Córdoba
2005-2022
Hospital Universitario Reina Sofía
1999-2022
University of Siena
2019
Instituto Maimónides de Investigación Biomédica de Córdoba
2019
Universidad Técnica del Norte
2016
Sofia University "St. Kliment Ohridski"
2013
Universidad de Granada
1997
Hospital Materno-Infantil
1995
Hospital Universitario Fundación Jiménez Díaz
1984-1989
IL-17-producing CD4+ T lymphocytes (Th17) are currently considered relevant participants in the pathogenesis of psoriasis skin lesions. However, little is known about potential role CD8+ cells, which also present at psoriatic plaque. We have addressed functional characterization this subtype from patients. Our results show that CD8+IL-17+ cells psoriasis-inflamed tissue produce TNF-alpha and IFN-gamma (Th1-related cytokines) as well IL-17, IL-21, IL-22 (Th17-related efficiently. A...
Hepatoblastoma (HB) is a rare disease. Nevertheless, it the predominant pediatric liver cancer, with limited therapeutic options for patients aggressive tumors. Herein, we aimed to uncover mechanisms of HB pathobiology and identify new biomarkers targets in move towards precision medicine advanced HB.We performed comprehensive genomic, transcriptomic epigenomic characterization 159 clinically annotated samples from 113 HB, using high-throughput technologies.We discovered widespread...
Clinical Implications•A patient with X-linked agammaglobulinemia was infected severe acute respiratory syndrome coronavirus 2 and presented a 40-day long stagnant clinical evolution refractory to treatment. The received single dose of disease 2019 convalescent plasma experienced rapid improvement within 1 week infusion. •A high infectivity the (SARS-CoV-2), lack preexisting immunity among population, complexity (COVID-19) presentation are some underlying reasons ongoing worldwide health...
The European Liver Transplant Registry (ELTR) has collected data on liver transplant procedures performed in Europe since 1968.Over a 50-year period (1968-2017), clinical and laboratory were from 133 centers analyzed retrospectively (16,641 transplants 14,515 children). Data according to three successive periods (A, before 2000; B, 2000-2009; C, 2010), studying donor graft characteristics outcome. use of living donors steadily increased A C n = 296 [7%]; 1131 [23%]; 1985 [39%]; p 0.0001)....
In four patients with alkaline-encrusted cystitis, Corynebacterium group D2 was isolated from consecutive urine cultures and stones. Encrusted cystitis occurred in bladders harboring inflammatory or tumorous lesions chronic recurrent urinary tract infections appearing after surgery instrumentation. The urease activity of the neutralization this enzyme by acetohydroxamic acid are shown. Clinical improvement, disappearance struvite crystals, decrease pH were obtained when these bacteria...
Celiac disease (CD) is a disorder characterized by deregulated immune response to ingested wheat gluten and related cereal proteins in susceptible individuals. It has been considered that the onset of CD mediated skewed Th1 response. However, participation Th17 cells pathogenesis disease, key cell population other autoimmune disorders, not studied detail. We have investigated presence mucosa active patients their functional implications disease.T obtained from duodenum biopsies 15 untreated...
Corynebacterium group D2 inoculated into normal human urine formed struvite crystals and an increase in pH ammonium concentration after 24 h of incubation. Zinc disks dipped a broth culture this microorganism inserted the bladders rats produced stones with mean weight 12.5 mg (ranging from 1 to 57.7 mg) 12 days. Analysis infrared spectrum determined be composed struvite. From these results its seems that stone formation by may possible both vitro vivo, which confirm previous report involving...
To determine the prevalence of Corynebacterium group D2 and JK organisms on skin different types patients, 200 hospitalized subjects, half them admitted to a university hospital others in chronic care institution, were surveyed. Samples taken from axilla, groin, abdominal wall. isolated at least one three sites both groups patients. Only five patients harbored same time but sites. The rate colonization by was higher females (43.3%) than males (17.7%); contrary, more frequently (32.1%)...
Livers from donation after circulatory death (DCD) donors are an increasingly more common source of organs for transplantation. While there few high-level studies in the field DCD liver transplantation, clinical practice has undergone progressive changes during past decade, particular due to mounting use postmortem normothermic regional perfusion (NRP). In Spain, uncontrolled been performed since late 1980s/early 1990s, while controlled was implemented nationally 2012. Since 2012, rise...
SUMMARY Dysfunction of cytotoxic activity T and natural killer (NK) lymphocytes is a main immunological feature in patients with AIDS, but its basis are not well understood. It has been recently described that NK cell-mediated cytotoxicity can be regulated by HLA inhibitory receptors (KIR). In this work, we have determined on cells from HIV-1-infected individuals the expression following KIR molecules: p58, p70, ILT2 (immunoglobulin-like family KIR) as CD94 NKG2A (C-lectin-type KIR). With...
Epstein-Barr virus (EBV) infection after liver transplantation (LT) is associated with increased risk of posttransplant lymphoproliferative disorder (PTLD). Lowering immunosuppression the current method to prevent PTLD in LT children a high viral load. The aim this study was assess efficacy and safety valganciclovir (VGCV) EBV LT. Forty-seven showing detectable EBV-DNA (72% asymptomatic) were treated VGCV (520 mg/sqm twice daily) no decrease (except 4 cases). treatment started 17 months...
Aim Short bowel syndrome (SBS) is the leading cause of intestinal failure (IF) in pediatric population. Our aim was to review long-term outcome ultrashort (USBS) an Intestinal Rehabilitation Unit (IRU). Patients and Methods Retrospective study patients with USBS (defined as < 10 cm remnant small bowel) treated between 2000 2015. Demographic data, clinical, treatment variables including parenteral nutrition (PN), surgical techniques, transplantation (IT) were analyzed. Results Out 250...
Rejection is one of the most important drawbacks for graft and patient survival in intestinal multivisceral transplantation. However, there no consensus on diagnostic criteria humoral rejection, literature about role donor-specific antibodies (DSA) allograft outcome risk factors that contribute to their development scant with contradictory results. The present study analyzes DSA exclusively a pediatric cohort 43 transplants. Among our patients, 11.6% showed preformed DSA, but they did not...
Defective T cell functions, including IL-2 production and proliferation, have been shown in SLE patients. After stimulation (first signal), a costimulatory signal (second signal) is required to achieve complete activation. Main signals are provided cells by B7 antigens (CD80 CD86, expressed on antigen-presenting (APC)) upon interaction with its receptor, the CD28 molecule cells. The aim of this study was investigate role CD28/B7 interactions impaired responses We show that...
The in vitro activities of nine antimicrobial agents against Corynebacterium group D2 strains isolated from clinical specimens and healthy skin hospitalized patients were studied. Ciprofloxacin, ofloxacin, norfloxacin, vancomycin, teicoplanin very active these microorganisms. There no significant differences susceptibility between colonizing isolates.
Congenital portosystemic shunt (CPSS) is a rare entity without insufficiency in treatment issues. The aim of this article to show our experience the heterogeneity condition.A retrospective study 25 CPSS period 1995 2014 was conducted. Description morphology, clinical impact, and given.According imaging techniques (IT), apparently intrahepatic 14 patients, extrahepatic 10 mixed 1 patient. In children, IT showed hepatic portal circulation. total shunts which radiological examination performed,...
Acquired airway stenosis is a common complication in children after periods of tracheal intubation. We reviewed our experience the endoscopic treatment these lesions.We performed retrospective review patients who presented acquired tracheal-subglottic (SGS) treated at center from 2005 to 2012. etiology, age, clinical presentation, methods diagnosis, number bronchoscopies, angioplasty balloon dilations performed, and long-term results.A total 18 (13 M, 5 F) were institution between Median age...