IL-17-producing CD4+ T lymphocytes (Th17) are currently considered relevant participants in the pathogenesis of psoriasis skin lesions. However, little is known about potential role CD8+ cells, which also present at psoriatic plaque. We have addressed functional characterization this subtype from patients. Our results show that CD8+IL-17+ cells psoriasis-inflamed tissue produce TNF-alpha and IFN-gamma (Th1-related cytokines) as well IL-17, IL-21, IL-22 (Th17-related efficiently. A...

Abstract The integration of IoT in healthcare has introduced vulnerabilities medical devices and software, posing risks to patient safety system integrity. This study aims bridge the research gap provide valuable insights for addressing their mitigation mechanisms. Software related health systems from 2001 2022 were collected National Vulnerability Database (NVD) systematized by software developed researchers assessed a specialist impact on well-being. analysis revealed electronic records,...

This paper presents the results of an educational experiment conducted to determine whether automated, card-based gamification strategy has impact on learning Jakob Nielsen's 10 heuristic usability rules. The participants in were 55 students enrolled a human-computer interaction course. According and hypothesis tests performed compare both traditional gamified approaches, there no significant differences (t (53) = 0.66, p 0.52), although scores attained by who used slightly better when...

Requirements engineering (RE) tools are increasingly used to ease the RE processes and allow for more systematic formalized handling of requirements, change management traceability. For developers companies evaluating use it is thus essential know which supported by how they fit their own priorities. The answer isn't easy because many sales prospects highlight numerous features—yet leave out degree they're whether all features really matter. To gain insight into current adapt activities, we...

The global increase in the proportion of population with disabilities has caused a greater awareness toward guaranteeing their use public services. In particular, there is emphasis on accessibility and inclusivity tourism resources, to improve enjoyment well-being for people motor disabilities. This paper presents case study beaches Region Murcia, Spain, which one main tourist areas country. First, most important elements that allow accessible are analyzed exposed detail. Then, an extensive...

Requirements engineering (RE) is a critical process in software development which faces important risks when performed global (GSD) setting. Some of these are specific to GSD, while others also appear co-localized environments but aggravated GSD. A systematic literature review (SLR) has been conducted identify the RE that occur along with safeguards manage risks. Inspired by grounded theory approach, and have elicited grouped means collaborative tagging cluster analysis techniques, then...

Global Software Development (GSD) is a well established field of software engineering with the benefits global environment. Project Management (SPM) plays key role in success GSD. As result, need has arisen to study and evaluate downsides SPM for GSD, thereby pave way development new methods, techniques, tools which tackle them. This paper aims identify classify research on approaches GSD that are available literature, their current weaknesses strengths, analyze applications industry. We...

Affective facial expressions are potent social cues that can induce relevant physiological changes, as well behavioral dispositions in the observer. Previous studies have revealed angry faces induced significant reductions body sway compared with neutral and happy faces, reflecting an avoidance tendency freezing. The expression of pain is usually considered unpleasant stimulus, but also a cue for delivering effective care support. Nevertheless, there few data about elicited by observation...

Global software development (GSD) which is a growing trend in the industry characterized by highly distributed environment. Performing project management (SPM) such conditions implies need to overcome new limitations resulting from cultural, temporal and geographic separation. The aim of this research discover classify various tools mentioned literature that provide GSD managers with support identify what way they group interaction. A systematic mapping study has been performed means...

This paper presents three experiments to assess the impact of gamifying an audience response system on perceptions and educational performance students. An called SIDRA (Immediate Audience Response System in Spanish) two systems with gamification features, R-G-SIDRA (gamified ranking) RB-G-SIDRA ranking badges), were used a General Descriptive Human Anatomy course. Students participated empirical study. In academic year 2019–2020, total 90 students RB-G-SIDRA, employed 2018–2019, 92...

Abstract Green information technologies (GITs) constitute a field of research, whose objective is to reduce the environmental pollution caused by masses people using and producing technology. This paper describes search for literature related GIT technology sustainability in Scopus database. No restriction was imposed on time period when carrying out search. The data gathered revealed that journal with highest number publications Computer, most prolific author Tomoya Enokido, 45...

People with motor disabilities must face many barriers and obstacles in their daily lives, making it difficult to perform everyday tasks. The purpose of this work is improve living conditions by providing an app accessibility information updated, reliable friendly form. development the system integrates national regional regulations, architectural aspects, extensive field work, a sustainable software process. levels requirements application are defined first phases project. included...

The current capabilities of cloud-based educational services are researched on the example Competence-Based Assessment implementation as cloud service for Software Engineering programs. In this paper, a conceptual Cloud Service based model and process automatic evaluation competences applied to field is proposed. proposal multiple choice tests instrument establishment relationship among competences, learning outcomes criterion rubrics used assessment. By linking students can know their...

<p>Requirements engineering (RE) is a discipline of critical importance in software development. This paper provides process and set artefacts to help the production e-archaeology systems with emphasis on requirements reuse standards. In particular, two important guidelines field earchaeology, London Charter Principles Seville, have been shown as sources be considered starting point for developing this type systems.</p>

The appearance of electronic health records has led to the need strengthen security personal data in order ensure privacy. Despite large number technical measures and recommendations that exist protect data, there is an increase violations privacy patients' healthcare organizations, which many cases caused by mistakes or oversights professionals. In this paper, we present a guide good practice for information handling personnel, drawn from recommendations, regulations national international...