A5101971669- Testicular diseases and treatments
- Multiple Myeloma Research and Treatments
- Head and Neck Cancer Studies
- Childhood Cancer Survivors' Quality of Life
- Cancer Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer-related cognitive impairment studies
- Cancer survivorship and care
- CAR-T cell therapy research
- Cancer Treatment and Pharmacology
- Endometrial and Cervical Cancer Treatments
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Cutaneous Melanoma Detection and Management
- Stress and Burnout Research
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Tracheal and airway disorders
- Child and Adolescent Psychosocial and Emotional Development
- Peptidase Inhibition and Analysis
- Nursing care and research
- Pharmacological Effects and Toxicity Studies
Instituto Nacional de Cancerología
2014-2024
Althaia
2024
John Wiley & Sons (United States)
2023
Hudson Institute
2023
University of Oxford
2023
John Wiley & Sons (United Kingdom)
2023
University of Illinois Chicago
2023
Instituto Maimónides de Investigación Biomédica de Córdoba
2022
Hospital Universitario Reina Sofía
2017-2022
Instituto Nacional del Cáncer
2020
CheckMate 651 (ClinicalTrials.gov identifier: NCT02741570) evaluated first-line nivolumab plus ipilimumab versus EXTREME (cetuximab cisplatin/carboplatin fluorouracil ≤ six cycles, then cetuximab maintenance) in recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN).
Summary A survey of laryngeal mask airway usage in 1400 infants and children by ten trainee anaesthetists was undertaken to provide information about insertion complication rates using the standard technique a limited range standardised anaesthetic techniques. Placement successful 90% (1258/1400) at first attempt, 8% (112/1400) second attempt 2% (29/1400) required an alternative insertion. One patient vomited during procedure abandoned, hut aspiration did not occur. The overall problem rate...
Clinical Implications•A patient with X-linked agammaglobulinemia was infected severe acute respiratory syndrome coronavirus 2 and presented a 40-day long stagnant clinical evolution refractory to treatment. The received single dose of disease 2019 convalescent plasma experienced rapid improvement within 1 week infusion. •A high infectivity the (SARS-CoV-2), lack preexisting immunity among population, complexity (COVID-19) presentation are some underlying reasons ongoing worldwide health...
Decidualized endometrial stromal cells from mid- to late secretory phase and decidual gestational human endometrium displayed prominent immunohistochemical staining for tissue factor, a primary initiator of hemostasis. Consistent with the regulation by progesterone decidualization process in vivo, medroxy-progesterone acetate elevated factor content cell cultures 8-fold over basal values. This increase paralleled release immunoreactive PRL, marker decidualization. The induced, as well basal,...
This randomized phase II trial evaluated whether the combination of cisplatin and paclitaxel (PC) plus all-trans retinoic acid (ATRA) increases response rate (RR) progression-free survival (PFS) in patients with advanced non-small-cell lung cancer (NSCLC) an acceptable toxicity profile its association expression receptor beta 2 (RAR-beta2) as a biomarker.Patients stages IIIB pleural effusion IV NSCLC were included to receive PC, randomly assigned ATRA 20 mg/m(2)/d (RA/PC) or placebo (P/PC) 1...
Resumen Antecedentes. La sintomatología ansiosa y depresiva es parte de los principales problemas salud mental en pacientes oncológicos, lo cual afecta la calidad vida adhesión al tratamiento, además que se asocia con mayor número síntomas estancia hospitalaria. Mediante instrumentos tamizaje válidos confiables, como Escala hospitalaria ansiedad depresión (HADS), ha sido posible detectar posibles casos hospitalarios. Sin embargo, hasta ahora no habían caracterizado las propiedades...
• Epignathus is a rare tumor of newborns that associated with high mortality secondary to airway obstruction in the neonatal period. Due recent advances prenatal ultrasound and magnetic resonance imaging techniques, accurate utero diagnosis this teratoma will enable health care team prepare for "emergency" management difficult airway. We present case newborn large epignathus diagnosed prenatally who underwent tracheotomy intact maternal-fetal circulation. After stabilization, circulation was...
Potential involvement of immune system in pathophysiology congenital glaucoma, cataract, and retinopathy prematurity (ROP) infants has been suggested. However, its understanding still remains limited. T regulatory cells (CD4 + CD25 high FoxP3 CD127 low ), with their role autoimmunity, are considered pivotal this respect, although there is a scarcity publications context. This study aims to address gap. Our purpose was compare the levels blood ) phenotype ROP, glaucoma healthy full-term...
Introduction: Adjuvant treatment for patients with stage I non-seminomatous germ cell tumors (NSGCT) could be active surveillance (AS), chemotherapy, or retro-peritoneal lymph node dissection (RLND). AS is the preferred option in most cas-es. The aim of this study was to evaluate long-term survival and prognostic factors our population approach. Methods: We collected information from NSGCT testis medical records 1995 2016. Patients had negative serum tumor mark-ers imaging chest, abdomen,...
Objective To assess the performance of general severity systems (Acute Physiology and Chronic Health Evaluation [APACHE] II, Simplified Acute Score [SAPS] Mortality Probability Models [MPM] II) for head trauma patients to compare these with Glasgow Coma Score, in order obtain a good estimate illness probability hospital mortality. Design Inception cohort. Setting Adult medical surgical intensive care units 12 European North American countries. Patients (n = 401) who were diagnosed...
Background New methods of rapid opiate detoxification, under intravenous sedation, can detoxify heroin-addicted patients in 24 hours. Their clinical application has been limited by the lack studies establishing both efficacy and safety. Method In a randomised, controlled study, 300 treatment-refractory, received detoxification treatment (naloxone infusion, 0.06–0.08 mg/kg, then oral naltrexone 50 mg/day) either monitored light sedation or unmonitored deep sedation. Results All were...
This study examined steroidal regulation of tissue factor expression by cultured endometrial stromal cells. Confluent cell cultures derived from cycling human endometria were exposed to vehicle control, 10(-8) mol/L estradiol (E2), 10(-8)-10(-6) medroxyprogesterone acetate (MPA), or both E2 and MPA for 2-24 days in serum-containing medium. The progestin enhanced immunoreactive functionally active content, achieving peak effects 8-12 culture. Although alone was ineffective, it augmented...
Introduction: Depressive symptomatology is a major mental health problem in cancer patients. The Beck Anxiety Scale (BAI) has proven to be reliable and valid instrument. However, until now not been documented it's psychometric properties Mexican population with cancer.Objetives: Determine the of BAI sample Material methods: Involved 250 patients from National Cancer Institute, which 112 were women (55.2%) male 138 (44.82%); average age was 46.6 ± 14.3 years. Participants answered BAI, also...
Orbital mesenchymal chondrosarcoma is a very uncommon lesion of the bone and extraskeletal tissue. To our knowledge, approximately 30 cases have been described. We present case 52-year-old male who presented with history progressive proptosis chemosis right eye caused by an orbital tumor. He underwent exenteration orbit, histological examination revealed chondrosarcoma. This paper attempts to describe rare entity that should be considered in differential diagnosis calcified lesions,...
Neuroendocrine differentiation of prostate cancer (NEDPC) includes de novo presentation and secondary to epigenetic changes, referred as therapy-induced neuroendocrine (t-NEPC). Molecular imaging with prostate-specific membrane antigen (PSMA) somatostatin analogues positron emission tomography (PET/CT) in NEDPC have not been validated. 18F-FDG (fluorodeoxyglucose) PET/CT has numerous limitations (PCa) the utility only reported a few series cases. The objective this study is compare lesions...
Melanoma represents one of the most aggressive malignancies and has a high tendency to metastasize. The present study aims investigate molecular mechanisms two pathways cancer transformation with purpose identifying potential biomarkers. Our approach is based on meta-analysis gene expression profiling contrasting scenarios: A model that describes pathway from melanocyte melanoma second where occurs through an intermediary nevus. Data consists three independent, publicly available microarray...
Abstract Our objective was to assess the accuracy of ultrasonographic estimation fetal weight in twins and triplets as compared singleton pregnancies. Retrospective analysis undertaken ultrasound data all fetuses who underwent an examination within 1 week delivery (singletons 1832, 518, 51). At birth weights below 2500 g, there a significant overestimation singletons, but estimate same, except between 1500 2499 when based on abdominal circumference femur length alone. more than no difference...