Antonio González
A5100626105- Natural product bioactivities and synthesis
- Rheumatoid Arthritis Research and Therapies
- Sesquiterpenes and Asteraceae Studies
- Systemic Lupus Erythematosus Research
- Osteoarthritis Treatment and Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Natural Compounds in Disease Treatment
- Marine Sponges and Natural Products
- Cytokine Signaling Pathways and Interactions
- Plant Toxicity and Pharmacological Properties
- Gut microbiota and health
- Phytochemistry and Biological Activities
- Phytochemical Studies and Bioactivities
- Employment, Labor, and Gender Studies
- Inflammatory mediators and NSAID effects
- Synthetic Organic Chemistry Methods
- Plant biochemistry and biosynthesis
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Bioactive Compounds and Antitumor Agents
- Labor Law and Work Dynamics
- Trypanosoma species research and implications
- Traditional and Medicinal Uses of Annonaceae
- Chemical synthesis and alkaloids
- Chronic Lymphocytic Leukemia Research
Instituto de Investigación Sanitaria de Santiago
2015-2024
University of San Diego
2024
The University of Texas at Austin
2004-2024
Hebron University
2024
University of California, San Diego
2015-2023
Spanish Ovarian Cancer Research Group
2023
National Nuclear Energy Commission
2023
Instituto de Instrumentación para Imagen Molecular
2023
Universidad Complutense de Madrid
2022
Center for Autism and Related Disorders
2022
Studies of the human microbiome have revealed that even healthy individuals differ remarkably in microbes occupy habitats such as gut, skin and vagina. Much this diversity remains unexplained, although diet, environment, host genetics early microbial exposure all been implicated. Accordingly, to characterize ecology human-associated communities, Human Microbiome Project has analysed largest cohort set distinct, clinically relevant body so far. We found abundance each habitat's signature vary...
In all higher plants studied to date, the anthocyanin pigment pathway is regulated by a suite of transcription factors that include Myb, bHLH and WD-repeat proteins. However, in Arabidopsis thaliana, Myb regulators remain be conclusively identified, little known about regulation TTG1-dependent transcriptional complexes. Previous overexpression PAP1 suggested genes from entire phenylpropanoid are targets Myb/bHLH/WD-repeat complexes Arabidopsis, contrast other plants. Here we demonstrate...
Abstract Background As microbial ecologists take advantage of high-throughput sequencing technologies to describe communities across ever-increasing numbers samples, new analysis tools are required relate the distribution microbes among larger communities, and use increasingly rich standards-compliant metadata understand biological factors driving these relationships. In particular, Earth Microbiome Project drives needs by profiling genomic content tens thousands samples multiple environment...
Abstract Background Understanding the normal temporal variation in human microbiome is critical to developing treatments for putative microbiome-related afflictions such as obesity, Crohn's disease, inflammatory bowel disease and malnutrition. Sequencing computational technologies, however, have been a limiting factor performing dense time series analysis of microbiome. Here, we present largest microbiota date, covering two individuals at four body sites over 396 timepoints. Results We find...
GLABRA3 (GL3) encodes a bHLH protein that interacts with the WD repeat protein, TTG1. GL3 overexpression suppresses trichome defect of pleiotropic ttg1 mutations. However, single gl3 mutations only affect pathway modest number reduction. A novel unlinked bHLH-encoding locus is described here, ENHANCER OF (EGL3). When mutated, egl3 gives totally glabrous plants in mutant background. The double mutant, egl3, has phenotype like having defective anthocyanin production, seed coat mucilage and...
We present QIIME 2, an open-source microbiome data science platform accessible to users spanning the research ecosystem, from scientists and engineers clinicians policy makers. 2 provides new features that will drive next generation of research. These include interactive spatial temporal analysis visualization tools, support for metabolomics shotgun metagenomics analysis, automated provenance tracking ensure reproducible, transparent science.
We present QIIME 2, an open-source microbiome data science platform accessible to users spanning the research ecosystem, from scientists and engineers clinicians policy makers. 2 provides new features that will drive next generation of research. These include interactive spatial temporal analysis visualization tools, support for metabolomics shotgun metagenomics analysis, automated provenance tracking ensure reproducible, transparent science.
The position-dependent specification of the hair and non-hair cell types in Arabidopsis root epidermis provides a simple model for study fate determination plants. Several putative transcriptional regulators are known to influence this decision. Indirect evidence from studies with maize R gene has been used suggest that bHLH transcription factor also participates process. We show two genes encoding proteins, GLABRA3(GL3) ENHANCER OF GLABRA3 (EGL3), act partially redundant manner specify...
Genomewide association studies of autoimmune diseases have mapped hundreds susceptibility regions in the genome. However, only for a few signals has causal gene been identified, and even fewer variant underlying mechanism defined. Coincident associations DNA variants affecting both risk disease quantitative immune variables provide an informative route to explore mechanisms drug-targetable pathways.Using case-control samples from Sardinia, Italy, we performed genomewide study multiple...
Mammals have diversified into many dietary niches. Specialized myrmecophagous (ant- and termite-eating) placental mammals represent a textbook example of evolutionary convergence driven by extreme diet specialization. Armadillos, anteaters, aardvarks, pangolins aardwolves thus provide model system for understanding the potential role gut microbiota in convergent adaptation to myrmecophagy. Here, we expand upon previous mammalian microbiome studies using high-throughput barcoded Illumina...
Abstract To capture the full spectrum of genetic risk for autism, we performed a two-stage analysis rare de novo and inherited coding variants in 42,607 autism cases, including 35,130 new cases recruited online by SPARK. We identified 60 genes with exome-wide significance ( P < 2.5 × 10 −6 ), five NAV3 , ITSN1 MARK2 SCAF1 HNRNPUL2 ). The association is primarily driven loss-of-function (LoF) variants, an estimated relative 4, consistent moderate effect. Autistic individuals LoF four...
We present QIIME 2, an open-source microbiome data science platform accessible to users spanning the research ecosystem, from scientists and engineers clinicians policy makers. 2 provides new features that will drive next generation of research. These include interactive spatial temporal analysis visualization tools, support for metabolomics shotgun metagenomics analysis, automated provenance tracking ensure reproducible, transparent science.
Structural genetic alterations in cancer often involve gene loss or amplification. With the advent of microarray approaches for analysis genome, as exemplified by array–CGH ( C omparative G enomic H ybridization), scanning gene-dosage is limited only issues DNA density. However, samples interest to pathologist comprise small clusters just a few hundred cells, which do not provide sufficient analysis. We sought develop simple method that would permit amplification whole genome without use...
The specification of the hair and non-hair cells in Arabidopsis root epidermis provides a useful model for study cell fate determination plants. A network putative transcriptional regulators, including related bHLH proteins GLABRA3 (GL3) ENHANCER OF (EGL3), is known to influence patterning these types. Here, we analyze expression regulation GL3 EGL3 during development. Although they are thought act both types, surprisingly found that gene RNA accumulation occurs preferentially developing...
Abstract While it is generally accepted that T cells are critical for the development of diabetes in non‐obese diabetic (NOD) mouse, precise functions CD4 + and CD8 subsets remain ill‐defined. Transfer experiments have provided evidence disease initiators, provoking massive mononuclear leukocyte infiltration into pancreatic islets, while play an effector role, responsible final destruction islet beta cells. It was surprising, then, to find NOD mice carrying a null mutation at...