A5020628068- Reproductive tract infections research
- Gut microbiota and health
- Urinary Tract Infections Management
- Microbial Metabolic Engineering and Bioproduction
- Studies on Chitinases and Chitosanases
- Biofuel production and bioconversion
- Facility Location and Emergency Management
- Advanced Statistical Methods and Models
- Forensic and Genetic Research
- Pelvic floor disorders treatments
- Face and Expression Recognition
- Reproductive System and Pregnancy
- Transportation Planning and Optimization
- Multi-Criteria Decision Making
- Forensic Anthropology and Bioarchaeology Studies
- Preterm Birth and Chorioamnionitis
- Gene Regulatory Network Analysis
- Explainable Artificial Intelligence (XAI)
- Process Optimization and Integration
- Advanced Statistical Process Monitoring
- Vehicle Routing Optimization Methods
- Advanced Optimization Algorithms Research
- Molecular Biology Techniques and Applications
- Biosensors and Analytical Detection
- Machine Learning in Healthcare
Virginia Commonwealth University
2015-2024
Georgia Institute of Technology
2002-2013
Statistical Research (United States)
2010
Glacier National Park
1925
Studies of the human microbiome have revealed that even healthy individuals differ remarkably in microbes occupy habitats such as gut, skin and vagina. Much this diversity remains unexplained, although diet, environment, host genetics early microbial exposure all been implicated. Accordingly, to characterize ecology human-associated communities, Human Microbiome Project has analysed largest cohort set distinct, clinically relevant body so far. We found abundance each habitat's signature vary...
Abstract The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in the frequency among populations within countries, and women African ancestry disproportionately bear burden risk United States. In present study, we report a community resource that includes ‘omics’ data from approximately 12,000 samples as part integrative Human Microbiome Project. Longitudinal analyses 16S ribosomal RNA, metagenomic, metatranscriptomic cytokine profiles 45 90 term controls...
Women of European ancestry are more likely to harbour a Lactobacillus -dominated microbiome, whereas African American women exhibit diverse microbial profile. also twice as be diagnosed with bacterial vaginosis and experience preterm birth. The objective this study was further characterize contrast the vaginal profiles in versus women. Through Vaginal Human Microbiome Project at Virginia Commonwealth University, 16S rRNA gene sequence analysis used compare microbiomes samples from 1268 416...
Characterizing microbial communities via next-generation sequencing is subject to a number of pitfalls involving sample processing. The observed community composition can be severe distortion the quantities bacteria actually present in microbiome, hampering analysis and threatening validity conclusions from metagenomic studies. We introduce an experimental protocol using mock for quantifying characterizing bias introduced processing pipeline. used 80 bacterial comprised prescribed...
This paper presents new biostatistical methods for the analysis of microbiome data based on a fully parametric approach using all data. The Dirichlet-multinomial distribution allows analyst to calculate power and sample sizes experimental design, perform tests hypotheses (e.g., compare microbiomes across groups), estimate parameters describing properties. use model these has benefit over alternative non-parametric approaches such as bootstrapping permutation testing, in that this is able...
The application of next-generation sequencing to the study vaginal microbiome is revealing spectrum microbial communities that inhabit human vagina. High-resolution identification bacterial taxa, minimally species level, necessary fully understand association with vaginosis, sexually transmitted infections, pregnancy complications, menopause, and other physiological infectious conditions. However, most current taxonomic assignment strategies based on metagenomic 16S rDNA sequence analysis...
In the interest of deriving classifiers that are robust to outlier observations, we present integer programming formulations Vapnik's support vector machine (SVM) with ramp loss and hard margin loss. The allows a maximum error 2 for each training observation, while calculates by counting number observations in or misclassified outside margin. SVM these functions is shown be consistent estimator when used certain kernel functions. computational studies simulated real-world data, ignores...
Background: Recent studies of various human microbiome habitats have revealed thousands bacterial species and the existence large variation in communities microorganisms same across individual subjects. Previous efforts to summarize this diversity, notably gut vagina, categorized profiles by clustering them into community state types (CSTs). The functional relevance specific CSTs has not been established. Objective: We investigate whether can be used assess dynamics microbiome. Design:...
Abstract Background Microorganisms possess diverse metabolic capabilities that can potentially be leveraged for efficient production of biofuels. Clostridium thermocellum (ATCC 27405) is a thermophilic anaerobe both cellulolytic and ethanologenic, meaning it directly use the plant sugar, cellulose, biochemically convert to ethanol. A major challenge in using microorganisms chemical need modify organism increase efficiency. The process properly engineering an typically arduous. Results Here...
The optimized profile descent is an example of one the many NextGen technologies under development to modernize and increase efficiency national airspace system. first publicly charted procedure was implemented at Los Angeles International Airport in December 2007. This new flight designed so that aircraft could conduct arrival approach operations with engines remaining or near minimum idle power settings; thereby, saving average 25 gal jet fuel per when compared various types conducting...
Humans are colonized by thousands of bacterial species, but it is difficult to assess the metabolic and pathogenic potential majority these because they have yet be cultured. Here, we characterize an uncultivated vaginal mycoplasma tightly associated with trichomoniasis that was previously known its 16S rRNA sequence as "Mnola." In this study, found almost exclusively in women infected sexually transmitted pathogen Trichomonas vaginalis, rarely observed no diagnosed disease. The genomes four...
The composition of the human vaginal microbiome has been extensively studied and is known to influence reproductive health. However, functional roles individual taxa their contributions negative health outcomes have yet be well characterized. Here, we examine two bacterial grouped within genus Megasphaera that previously associated with vaginosis (BV) pregnancy complications. Phylogenetic analyses support classification these as distinct species. These phylotypes, phylotype 1 (MP1) 2 (MP2),...
Bacterial vaginosis (BV) is the leading dysbiosis of vaginal microbiome. The pathways towards development BV are not well understood. Gardnerella vaginalis frequently associated with BV. G. produces cholesterol-dependent cytolysin (CDC), vaginolysin, which can lyse a variety human cells and thought to play role in pathogenesis. Because membrane cholesterol required for vaginolysin function, because HMG-CoA reductase inhibitors (statins) affect only serum levels but as well, we hypothesized...
Purpose – The purpose of this research paper is to describe quantitative methods that assist police administrators with evaluating current staffing and justifying local governing bodies the size patrol workforce required meet performance benchmarks. Design/methodology/approach A discrete-event simulation model developed analyze various levels alternative scheduling scenarios. Input distributions are based on computer-aided dispatch (CAD) data from an urban department. results can be used...