A5048330739- Reproductive tract infections research
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Gut microbiota and health
- Preterm Birth and Chorioamnionitis
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Genomics and Phylogenetic Studies
- Urological Disorders and Treatments
- Reproductive System and Pregnancy
- Indigenous Studies and Ecology
- Sexual function and dysfunction studies
- Plant and fungal interactions
- Reproductive Physiology in Livestock
- Parasitic Infections and Diagnostics
- Colorectal Cancer Screening and Detection
- Plant Pathogens and Fungal Diseases
- Reproductive Health and Contraception
- Fetal and Pediatric Neurological Disorders
- Infant Nutrition and Health
- Mycorrhizal Fungi and Plant Interactions
- Microbial infections and disease research
- Molecular Biology Techniques and Applications
- Pediatric health and respiratory diseases
- Microbial Community Ecology and Physiology
Virginia Commonwealth University
2014-2024
RELX Group (United States)
2017
University of the Philippines Diliman
2017
RELX Group (United Kingdom)
2017
Virginia Commonwealth University Medical Center
2012
Abstract The NIH Human Microbiome Project (HMP) has been carried out over ten years and two phases to provide resources, methods, discoveries that link interactions between humans their microbiomes health-related outcomes. recently completed second phase, the Integrative Project, comprised studies of dynamic changes in microbiome host under three conditions: pregnancy preterm birth; inflammatory bowel diseases; stressors affect individuals with prediabetes. associated research begins...
Abstract The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in the frequency among populations within countries, and women African ancestry disproportionately bear burden risk United States. In present study, we report a community resource that includes ‘omics’ data from approximately 12,000 samples as part integrative Human Microbiome Project. Longitudinal analyses 16S ribosomal RNA, metagenomic, metatranscriptomic cytokine profiles 45 90 term controls...
Women of European ancestry are more likely to harbour a Lactobacillus -dominated microbiome, whereas African American women exhibit diverse microbial profile. also twice as be diagnosed with bacterial vaginosis and experience preterm birth. The objective this study was further characterize contrast the vaginal profiles in versus women. Through Vaginal Human Microbiome Project at Virginia Commonwealth University, 16S rRNA gene sequence analysis used compare microbiomes samples from 1268 416...
Characterizing microbial communities via next-generation sequencing is subject to a number of pitfalls involving sample processing. The observed community composition can be severe distortion the quantities bacteria actually present in microbiome, hampering analysis and threatening validity conclusions from metagenomic studies. We introduce an experimental protocol using mock for quantifying characterizing bias introduced processing pipeline. used 80 bacterial comprised prescribed...
The application of next-generation sequencing to the study vaginal microbiome is revealing spectrum microbial communities that inhabit human vagina. High-resolution identification bacterial taxa, minimally species level, necessary fully understand association with vaginosis, sexually transmitted infections, pregnancy complications, menopause, and other physiological infectious conditions. However, most current taxonomic assignment strategies based on metagenomic 16S rDNA sequence analysis...
Abstract Background Bacteria of the genus Sneathia are emerging as potential pathogens female reproductive tract. Species , which were formerly grouped with Leptotrichia can be part normal microbiota genitourinary tracts men and women, but they also associated a variety clinical conditions including bacterial vaginosis, preeclampsia, preterm labor, spontaneous abortion, post-partum bacteremia other invasive infections. species exhibit significant correlation sexually transmitted diseases...
Background: Recent studies of various human microbiome habitats have revealed thousands bacterial species and the existence large variation in communities microorganisms same across individual subjects. Previous efforts to summarize this diversity, notably gut vagina, categorized profiles by clustering them into community state types (CSTs). The functional relevance specific CSTs has not been established. Objective: We investigate whether can be used assess dynamics microbiome. Design:...
Recent evidence suggests that chronic exposure to opioid analgesics such as morphine disrupts the intestinal epithelial layer and causes dysbiosis. Depleting gut bacteria can preclude development of tolerance opioid-induced antinociception, suggesting an important role gut-brain axis in mediating effects. The mechanism underlying dysbiosis, however, remains unclear. Host-produced antimicrobial peptides (AMPs) are critical for integrity barrier they prevent pathogenesis enteric microbiota....
Humans are colonized by thousands of bacterial species, but it is difficult to assess the metabolic and pathogenic potential majority these because they have yet be cultured. Here, we characterize an uncultivated vaginal mycoplasma tightly associated with trichomoniasis that was previously known its 16S rRNA sequence as "Mnola." In this study, found almost exclusively in women infected sexually transmitted pathogen Trichomonas vaginalis, rarely observed no diagnosed disease. The genomes four...
Vaginal lactobacilli can inhibit colonization by and growth of other bacteria, thereby preventing development bacterial vaginosis (BV). Amongst the lactobacilli, Lactobacillus crispatus appears to be particularly effective at inhibiting BV-associated bacteria. Nonetheless, some women who are colonized with this species still develop clinical BV. Therefore, we sought determine whether strains L. that colonize lactobacilli-dominated vaginal microbiomes distinct from The genomes isolates four (...
Approximately 10% of all pregnancies in the United States end preterm birth, and over 14% birth among Black women. Knowledge on associations between vaginal microbiome is important for understanding potential cause assessing risk birth.
<b>Objective</b> The oral cavity represents an initial entry way for and gut indigenous colonization. Skin-to-skin (STS) care, in which the mother holds diaper clad naked preterm (PT) infant between her breasts, is associated with improved digestive function, decreased stress, survival. This study evaluated development of microbial colonization repertoires health characteristics PT infants or without STS exposure. <b>Methods</b> Saliva from 42 (<32 weeks gestation at birth) was collected...
Abstract Objective The aim of this study was to evaluate the differences between vaginal microbiome reproductive‐aged women with overweight and obesity (Ow/Ob) compared healthy weight (HW). Methods In case‐control study, a cohort 367 nonpregnant (18 40 years) Ow/Ob (BMI ≥25 kg/m 2 ) case‐matched HW 18.0 24.9 ). secondary analysis 16S rRNA surveys through Vaginal Human Microbiome Study (VaHMP). Groups were matched on age, race/ethnicity, income, nulliparity status. Results Mean age BMI groups...
Trichomonas vaginalis can host the endosymbiont Mycoplasma hominis, an opportunistic pathogenic bacterium capable of modulating T. pathobiology. Recently, a new noncultivable mycoplasma, "
The composition of the human vaginal microbiome has been extensively studied and is known to influence reproductive health. However, functional roles individual taxa their contributions negative health outcomes have yet be well characterized. Here, we examine two bacterial grouped within genus Megasphaera that previously associated with vaginosis (BV) pregnancy complications. Phylogenetic analyses support classification these as distinct species. These phylotypes, phylotype 1 (MP1) 2 (MP2),...
Abstract Background The vaginal microbiome has been associated with adverse pregnancy outcomes, but information on the impact of diet composition is largely unexamined. Objective To estimate association between prenatal and microbiota overall by race. Methods We leveraged a racially diverse cohort North Carolina women enrolled 1995 2001 to conduct this analysis using cross‐sectional data. Women completed food frequency questionnaires about in previous 3 months foods were categorised into...