A5042887851- Gut microbiota and health
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Pain Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Pediatric Pain Management Techniques
- Pharmacological Effects of Natural Compounds
- Cannabis and Cannabinoid Research
- Dermatology and Skin Diseases
- Spaceflight effects on biology
- Anesthesia and Pain Management
- Human-Animal Interaction Studies
- Cynara cardunculus studies
- Neuroscience of respiration and sleep
- Ion Channels and Receptors
- Animal Behavior and Welfare Studies
- Algal biology and biofuel production
- Vitamin C and Antioxidants Research
- Phytochemicals and Antioxidant Activities
- Pharmacological Receptor Mechanisms and Effects
Virginia Commonwealth University
2021-2025
Bursa Uludağ Üni̇versi̇tesi̇
2019-2022
Recent evidence suggests that chronic exposure to opioid analgesics such as morphine disrupts the intestinal epithelial layer and causes dysbiosis. Depleting gut bacteria can preclude development of tolerance opioid-induced antinociception, suggesting an important role gut-brain axis in mediating effects. The mechanism underlying dysbiosis, however, remains unclear. Host-produced antimicrobial peptides (AMPs) are critical for integrity barrier they prevent pathogenesis enteric microbiota....
Transmembrane Ca v 2.2 (N-type) voltage-gated calcium channels are genetically and pharmacologically validated, clinically relevant pain targets. Clinical block of (e.g., with Prialt/Ziconotide) or indirect modulation [e.g., gabapentinoids such as Gabapentin (GBP)] mitigates chronic but is encumbered by side effects abuse liability. The cytosolic auxiliary subunit collapsin response mediator protein 2 (CRMP2) targets to the sensory neuron membrane regulates their function via an...
Chronic post-surgical pain affects a large proportion of people undergoing surgery, delaying recovery time and worsening quality life. Although many environmental variables have been established as risk factors, less is known about genetic risk. To uncover factors we performed genome-wide association studies in cohorts five surgery types- hysterectomy, mastectomy, abdominal, hernia, knee- totaling 1350 individuals. Genetic associations between chronic levels on numeric rating scale (NRS)...
Cannabis is among the most widely consumed psychoactive drugs around world and cannabis use disorder (CUD) has no current approved pharmacological treatment. Nicotine are commonly co-used which suggests there to be overlapping neurobiological actions supported primarily by co-distribution of both receptor systems in brain. There appears strong rationale explore role that nicotinic receptors play cannabinoid dependence. Preclinical studies suggest ɑ7 nAChR subtype may a modulating reinforcing...
Stress is a complex phenomenon and exposure to stress results in series of reactions the organism, including alterations behaviour various physiological changes. Role nutrition maintenance homeostatic mechanisms, stress, very dense. The current study aimed evaluate potential effects Spirulina (Arthrospira) platensis against mix models. For this purpose, 36 Sprague-Dawley male rats were allocated into four groups; 1. Control(C), 2. Stress(S), 3. S.platensis (Sp) 4. S. + (SpS). was applied Sp...
Abstract Introduction There is a balance between oxidative stress, antioxidant capacity and immune response. Their roles in physiological behavioural mechanisms are important for the maintenance of organism’s internal equilibrium. This study aimed to evaluate effects exogenous alga Spirulina platensis (Arthrospira platensis) stress-induced rat model, describe its possible mechanism action. Material Methods Thirty-six adult male Sprague Dawley rats were separated into four groups: control...
Recent evidence suggests that chronic exposure to opioid analgesics such as morphine disrupt the intestinal epithelial layer and cause dysbiosis. Inhibiting opioid-induced dysbiosis can preclude development of tolerance antinociception, suggesting an important role gut-brain axis in mediating effects. However, mechanism underlying remains unclear. Host-produced antimicrobial peptides (AMPs) are critical for integrity barrier they prevent pathogenesis enteric microbiota. Here, we report...
Animal wellbeing is a balance between environmental stress and nutrition that regulates homeostasis. Augmentation of animal feed with essential oils can promote The present study was designed to observe the biochemical, immunological, biological effects daily administration mixture (EOM) in stressed rat model. Forty-eight adult male Sprague Dawley rats were randomly allocated four groups, namely control group (C), (S), treated (Tr), received treatment (TrS). applied by adding EOM water (0.2...
Opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are excellent analgesics, but recent clinical evidence suggests that these might worsen disease severity in Crohn's patients, limiting their utility for treating Inflammatory Bowel Disease (IBD). One indicator of change well-being from conditions such as IBD is behavioral depression disruption to activities daily living. Preclinical measures can provide an changes quality life subsequent modification by candidate analgesics. In mice,...
Management of pain post-surgery is crucial for tissue healing in both veterinary and human medicine. Overuse some analgesics such as opioids may lead to addictions worsen syndromes (opioid-induced hyperalgesia), while underuse it affect the welfare patient. Therefore, importance using surgery models laboratory animals increasing, with goal improving our understanding neurobiology developing safer analgesics. We compared widely used plantar incision model laparotomy measured pain-related...
<b>Abstract ID 90358</b> <b>Poster Board 097</b> Alpha-7 nicotinic acetylcholine receptors (α7-nAChRs) have been shown to play a role in pain and inflammation. These are expressed macrophages other myeloid lineage cells, which mediate the endogenous cholinergic anti-inflammatory pathway cultured immune cells leading attenuation of excess inflammation after insult. Animal models on activation α7-nAChRs with agonists show that receptor is antinociceptive reduces local tumor necrosis factor...
Abstract Recent evidence suggests that chronic exposure to opioid analgesics such as morphine disrupt the intestinal epithelial layer and cause dysbiosis. Inhibiting opioid-induced dysbiosis can preclude development of tolerance antinociception, suggesting an important role gut-brain axis in mediating effects. However, mechanism underlying remains unclear. Host-produced antimicrobial peptides (AMPs) are critical for integrity barrier they prevent pathogenesis enteric microbiota. Here, we...
<b>Abstract ID 19075</b> <b>Poster Board 368</b> <b>Introduction:</b> Recently, evidence from both preclinical<sup>1</sup> and clinical<sup>2</sup> studies indicates that chronic opioid use results in intestinal dysbiosis; eliminating the dysbiotic bacteria with antibiotics prevents onset of tolerance to antinociceptive effects<sup>1</sup>. However, mechanism underlying opioid-induced dysbiosis (OID) is unclear. One by which epithelium maintains microbiota through release antimicrobial...
Heart rate changes and respiratory activities are vital physiological phenomena that provide valuable insights into the psychological states of family dogs. The bond between humans their pet dogs necessitates a deeper understanding this relationship. Therefore, objective study was to investigate human-animal by examining heart (HR), variability (HRV), (breathe per minute, BPM), tidal volume (TV) using an external telemetry system. A total ten were selected as participants, cardio-respiratory...
Global animal feeding strategies have been modified due to several ecosystem changes that cause stress and decline in health, growth, yields. According the literature, natural additives fundamental health from day day. The present study measured antioxidant status, immunity, liver functions organ weights tested under conditions determine whether dietary supplementation with phytogenic additive could provide beneficial effects. Forty-eight adult, male Sprague-Dawley rats were randomly...